A5069060163- Schizophrenia research and treatment
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health Treatment and Access
- Mental Health Research Topics
- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Obsessive-Compulsive Spectrum Disorders
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Eating Disorders and Behaviors
- Genetic Associations and Epidemiology
- Children's Physical and Motor Development
- Genomic variations and chromosomal abnormalities
- Psychosomatic Disorders and Their Treatments
- Neuroendocrine regulation and behavior
- Tryptophan and brain disorders
- Genomics and Rare Diseases
- Neural and Behavioral Psychology Studies
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
Douglas Mental Health University Institute
2016-2025
McGill University
2016-2025
Great Minds
2025
Western University
2023-2024
Douglas College
2012-2024
McGill University Health Centre
1996-2024
HEC Montréal
2019-2023
Jewish General Hospital
2023
Cégep Saint-Jean-sur-Richelieu
2023
Montreal Neurological Institute and Hospital
2016-2023
Schizophrenia likely results from poorly understood genetic and environmental factors. We studied the gene encoding synaptic protein SHANK3 in 285 controls 185 schizophrenia patients with unaffected parents. Two de novo mutations (R1117X R536W) were identified two families, one being found three affected brothers, suggesting germline mosaicism. Zebrafish rat hippocampal neuron assays revealed behavior differentiation defects resulting R1117X mutant. As previously reported autism, occurrence...
Although autosomal forms of nonsyndromic mental retardation account for the majority cases retardation, genes that are involved remain largely unknown. We sequenced gene SYNGAP1, which encodes a ras GTPase-activating protein is critical cognition and synapse function, in 94 patients with retardation. identified de novo truncating mutations (K138X, R579X, L813RfsX22) three these patients. In contrast, we observed no or SYNGAP1 samples from 142 subjects autism spectrum disorders, 143...
Abstract A number of studies have confirmed that genetic factors play an important role in autism spectrum disorder (ASD). More recently de novo mutations the SHANK3 gene, a synaptic scaffolding protein, been associated with ASD phenotype. As part our gene discovery strategy, we sequenced cohort 427 subjects and 190 controls. Here, report identification two putative causative mutations: one being deletion at intronic donor splice site missense transmitted from epileptic father. We were able...
In this article we have provided a perspective on the importance and value of youth mental health services for society argued that advancing should be number one priority in Canada. Using age period 12-25 years defining youth, justification our position based scientific evidence derived from clinical, epidemiological neurodevelopmental studies. We highlighted early onset most disorders substance abuse as well their persistence into later adulthood, long delays experienced by help seekers...
Postmortem studies have indicated that suicide victims greater serotonin receptor 2A (5-HTR2A) binding in prefrontal brain regions. However, there remains some controversy regarding the biological specificity of these findings. The authors hypothesized variance observed 5-HTR2A is genetically mediated, at least part.Postmortem data from 56 subjects who had committed and 126 normal comparison were studied; tissue was available 11 subjects. Homogenate assays carried out with [3H]ketanserin....
Pharmacological, genetic and expression studies implicate N-methyl-D-aspartate (NMDA) receptor hypofunction in schizophrenia (SCZ). Similarly, several lines of evidence suggest that autism spectrum disorders (ASD) could be due to an imbalance between excitatory inhibitory neurotransmission. As part a project aimed at exploring rare and/or de novo mutations neurodevelopmental disorders, we have sequenced the seven genes encoding for NMDA subunits (NMDARs) large cohort individuals affected...
In a systematic sequencing screen of synaptic genes on the X chromosome, we have identified an autistic female without mental retardation (MR) who carries de novo frameshift Ile367SerfsX6 mutation in Interleukin-1 Receptor Accessory Protein-Like 1 (IL1RAPL1), gene implicated calcium-regulated vesicle release and dendrite differentiation. We showed that function resulting truncated IL1RAPL1 protein is severely altered hippocampal neurons, by measuring its effect neurite outgrowth activity....
Article AbstractObjective: Functional recovery remains the primary goal following treatment of a psychotic disorder, especially after first episode. Evidence regarding relative contributions predictors functional outcome, including symptoms and cognition, equivocal. The objective study was to determine contribution in particular verbal memory, symptomatic remission social occupational functioning while controlling for established large sample patients presenting with episode schizophrenia...