A5059764843- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health and Psychiatry
- Child Abuse and Trauma
- Neuroendocrine regulation and behavior
- Mental Health Research Topics
- Adrenal Hormones and Disorders
- Memory and Neural Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Hormonal Regulation and Hypertension
- Psychiatric care and mental health services
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- Obsessive-Compulsive Spectrum Disorders
- Heart Rate Variability and Autonomic Control
- Electrolyte and hormonal disorders
- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Personality Disorders and Psychopathology
- Mental Health Treatment and Access
- Psychosomatic Disorders and Their Treatments
- Neuroscience and Music Perception
McGill University
2014-2025
University of Konstanz
2017-2022
Douglas Mental Health University Institute
2011-2021
Douglas College
2007
Montreal Neurological Institute and Hospital
2001-2007
Objective There is evidence that clinical depression and negative mood are associated with elevated basal cortisol levels. Recently, measuring the response during first hour in morning strict reference to time of awakening was established as a reliable marker individual adrenocortical activity. In studies using this marker, relationship self-reported stress levels psychosomatic symptoms has been found. The goal present study investigate association depressive symptomatology early free their...
Magnetic Resonance Imaging (MRI) provides a noninvasive method for investigating brain morphology. Within the medial temporal lobe, special attention has been paid to hippocampus (HC) and amygdala (AG) because of their role in memory, depression, emotion, learning. Volume changes these areas have observed conjunction with certain disease states, e.g. Alzheimer's disease, post-traumatic stress disorder, depression. Aging also shown result gray matter volume loss overall brain, including HC....
Abstract Background The At Risk Mental State (ARMS) (also known as the Ultra or Clinical High Risk) criteria identify individuals at high risk for psychotic disorder. However, there is a need to improve prediction only about 18% of meeting these develop psychosis with 12-months. We have developed and internally validated model using characteristics that could be used in routine practice. Methods conducted systematic review individual participant data meta-analysis, followed by focus groups...
Abstract Increased activation of the hypothalamus pituitary adrenal (HPA) axis, marked by increased secretion cortisol, is a biological marker psychological stress. It well established that hippocampus plays an important role in regulation HPA axis activity. The relationship between cortisol (stress‐related elevation or exogenous administration) and hippocampal‐related cognitive function often examined. However, few human studies to date have examined effect stress on hippocampal activity...
Hippocampal volume (HV) decline is an important marker of psychosis and has been associated with hypothalamus-pituitary-adrenal (HPA) axis dysregulation in various disorders. Given recent findings sex differences HPA function psychosis, the current study investigated HV male female first episode (FEP) patients controls interaction cortisol awakening response (CAR) symptoms.Fifty-eight a diagnosis FEP (39 men, 19 women) 27 healthy community (15 12 underwent structural magnetic resonance...
Background Altered hypothalamus-pituitary-adrenal (HPA) axis function and reduced hippocampal volume (HV) are established correlates of stress vulnerability. We have previously shown an attenuated cortisol awakening response (CAR) associations with HV specifically in male first-episode psychosis patients. Findings individuals at ultra-high risk (UHR) for regarding these neurobiological markers inconsistent, assessment their interplay, accounting sex differences, could explain incongruent...
Background Negative symptoms are known to be present in the prodromal stage of psychotic disorders, yet little is about their prevalence. Studies examining presence negative ultra‐high risk ( UHR ) populations have shown some limitations, notably failing control depression. The objective this study was examine prevalence significant levels depression and absence such (primary symptoms) over 1 year differences psychosis converters non‐converters. Methods Participants were 123 individuals at...
Abstract Aim In the context of an increasing focus on indicated prevention psychotic disorders, we describe operation Clinic for Assessment Youth at Risk (CAYR) over 10 years, a specialized service identification, monitoring and treatment young individuals who meet ultra‐high risk (UHR) criteria psychosis, its integration within Prevention Early Intervention Program Psychosis (PEPP) in Montreal, Canada. Methods We outline rationale, development, inclusion exclusion criteria, assessment,...
Sex differences have been widely observed in clinical presentation, functional outcome and neuroanatomy individuals with a first-episode of psychosis, chronic patients suffering from schizophrenia. However, little is known about sex the high-risk stages for psychosis. The present study investigated cortical subcortical at high risk (CHR) psychosis healthy controls (CTL), relationship between anatomy symptoms males CHR. Magnetic resonance images were collected 26 CHR (13 men) 29 CTLs (15 to...
Abstract The stress-vulnerability model has been repeatedly highlighted in relation to the risk, onset and course of psychosis, independently studied clinical high-risk (CHR) first-episode psychosis (FEP) populations. Notable this literature, however, is that there are few studies directly comparing markers stress response across progressive stages illness. Here we examined psychobiological Trier Social Stress Test 28 CHR (mean age 19.1) 61 FEP (age 23.0) patients, order understand stage(s)...