A5034368203- Reproductive System and Pregnancy
- Neonatal and fetal brain pathology
- Tryptophan and brain disorders
- Birth, Development, and Health
- Cannabis and Cannabinoid Research
- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neurotransmitter Receptor Influence on Behavior
- Functional Brain Connectivity Studies
- Sleep and Wakefulness Research
- Prenatal Substance Exposure Effects
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Preterm Birth and Chorioamnionitis
- Advanced Neuroimaging Techniques and Applications
- Health, Environment, Cognitive Aging
- Advanced MRI Techniques and Applications
- Schizophrenia research and treatment
- Pregnancy and preeclampsia studies
- Neural dynamics and brain function
- Genetics and Neurodevelopmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Maternal Mental Health During Pregnancy and Postpartum
- Genetics, Aging, and Longevity in Model Organisms
- Adolescent and Pediatric Healthcare
Harvard University
2024-2025
Massachusetts General Hospital
2024-2025
Center for Autism and Related Disorders
2024-2025
National Institute of Mental Health
2021-2024
Athinoula A. Martinos Center for Biomedical Imaging
2024
Radboud University Nijmegen
2024
Wellcome Centre for Integrative Neuroimaging
2024
University of Oxford
2024
University of Toronto
2024
National Institute of Mental Health
2024
There is growing recognition that connectome architecture shapes cortical and subcortical gray matter atrophy across a spectrum of neurological psychiatric diseases. Whether connectivity contributes to tissue volume loss in schizophrenia the same manner remains unknown.Here, we relate patients with patterns structural functional connectivity. Gray deformation was estimated sample 133 individuals chronic (48 women, mean age 34.7 ± 12.9 years) 113 control subjects (64 23.5 8.4 years)....
Exposure to maternal immune activation (MIA) in utero is a risk factor for neurodevelopmental and psychiatric disorders. MIA-induced deficits adolescent adult offspring have been well characterized; however, less known about the effects of MIA exposure on embryo development. To address this gap, we performed high-resolution ex vivo MRI investigate early (gestational day [GD]9) late (GD17) (GD18) brain structure. We identify striking neuroanatomical changes brain, particularly late-exposed...
In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but causes of such are hard to parse. While mouse models useful for understanding cellular and mechanistic bases sex-specific brain development, there been no attempts formally compare neuroanatomical ascertain how well they translate. Addressing this question would shed critical light on use as a translational model provide insights into degree which volume conserved across...
In vivo neuroimaging studies have established several reproducible volumetric sex differences in the human brain, but causes of such are hard to parse. While mouse models useful for understanding cellular and mechanistic bases sex-specific brain development, there been no attempts formally compare neuroanatomical ascertain how well they translate. Addressing this question would shed critical light on use as a translational model provide insights into degree which volume conserved across...
All eutherian mammals show chromosomal sex determination with contrasting chromosome dosages (SCDs) between males (XY) and females (XX). Studies in transgenic mice humans trisomy (SCT) have revealed direct SCD effects on regional mammalian brain anatomy, but we lack a formal test for cross-species conservation of these effects. Here, develop harmonized framework comparative structural neuroimaging apply this to systematically profile anatomy both by groups SCT (XXY XYY) versus XY controls....
Our current understanding of litter variability in neurodevelopmental studies using mice may limit translation neuroscientific findings. Higher variance measures across litters than within, often termed intra-litter likeness, be attributable to both pre- and postnatal environment. This study aimed assess the litter-effect within behavioral assessments (2 timepoints) anatomy T1-weighted magnetic resonance images 72 brain region volumes (4 (36 C57bl/6J inbred mice; 7 litters: 19F/17M)....
Sex differences have been widely observed in clinical presentation, functional outcome and neuroanatomy individuals with a first-episode of psychosis, chronic patients suffering from schizophrenia. However, little is known about sex the high-risk stages for psychosis. The present study investigated cortical subcortical at high risk (CHR) psychosis healthy controls (CTL), relationship between anatomy symptoms males CHR. Magnetic resonance images were collected 26 CHR (13 men) 29 CTLs (15 to...
Prenatal exposure to maternal immune activation (MIA) is a risk factor for variety of neurodevelopmental and psychiatric disorders. The timing MIA-exposure has been shown affect adolescent adult offspring neurodevelopment, however, less known about these effects in the neonatal period. To better understand impact on brain development mouse model, we assess neonate communicative abilities with ultrasonic vocalization task, followed by high-resolution ex vivo magnetic resonance imaging (MRI)...
Noradrenaline (NE) plays an integral role in shaping behavioral outcomes including anxiety/depression, fear, learning and memory, attention shifting behavior, sleep-wake state, pain, addiction. However, it is unclear whether dysregulation of NE release a cause or consequence maladaptive orientations these behaviors, many which associated with psychiatric disorders. To address this question, we used unique genetic model the brain-specific vesicular monoamine transporter-2 (VMAT2) gene...
Clinical research has shown that chronic antipsychotic drug (APD) treatment further decreases cortical gray matter and hippocampus volume, increases striatal ventricular volume in patients with schizophrenia. D2-like receptor blockade is necessary for clinical efficacy of the drugs, may be responsible inducing these changes. However, role other receptors, such as D3, remains unclear. Following our previous work, we undertook a longitudinal study to examine effects (9-week) typical...
Abstract Background There is growing recognition that connectome architecture shapes cortical and sub-cortical grey matter atrophy across a spectrum of neurological psychiatric diseases. Whether connectivity contributes to tissue volume loss in schizophrenia the same manner remains unknown. Methods Here we relate patients with patterns structural functional connectivity. Grey deformation was estimated sample N = 133 individuals chronic (48 female, 34.7 ± 12.9 years) 113 controls (64 23.5 8.4...
Abstract While cannabis use during pregnancy is often perceived as harmless, little known about its consequences on offspring neurodevelopment. There an urgent need to map the effects of prenatal exposure brain through course lifespan. We used magnetic resonance imaging spanning nine timepoints, behavioral assays, and electron microscopy build a trajectory from gestation adulthood in mice exposed prenatally delta-9-tetrahydrocannabinol (THC). Our results demonstrate spatio-temporal...