Oussama Kébir
A5014502121- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Diet and metabolism studies
- Genetics and Neurodevelopmental Disorders
- Cannabis and Cannabinoid Research
- Autism Spectrum Disorder Research
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Attention Deficit Hyperactivity Disorder
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Mental Health and Psychiatry
- Genetic Syndromes and Imprinting
- Neuroscience and Neuropharmacology Research
- Mental Health Treatment and Access
- Genomic variations and chromosomal abnormalities
- Alcoholism and Thiamine Deficiency
- Bipolar Disorder and Treatment
- Mental Health Research Topics
- Neural and Behavioral Psychology Studies
- Neuroscience of respiration and sleep
- Hormonal Regulation and Hypertension
- Obsessive-Compulsive Spectrum Disorders
- Effects and risks of endocrine disrupting chemicals
Inserm
2015-2024
Université Paris Cité
2015-2024
Institut de Psychiatrie et Neurosciences de Paris
2015-2024
Centre Hospitalier Guillaume Régnier
2024
FHU Neurovasc
2020-2023
Centre Hospitalier Sainte-Anne
2008-2021
Centre National de la Recherche Scientifique
2019-2020
Université Paris-Est Créteil
2020
GHU Paris psychiatrie & neurosciences
2019-2020
Assistance Publique – Hôpitaux de Paris
2019
Pharmacological, genetic and expression studies implicate N-methyl-D-aspartate (NMDA) receptor hypofunction in schizophrenia (SCZ). Similarly, several lines of evidence suggest that autism spectrum disorders (ASD) could be due to an imbalance between excitatory inhibitory neurotransmission. As part a project aimed at exploring rare and/or de novo mutations neurodevelopmental disorders, we have sequenced the seven genes encoding for NMDA subunits (NMDARs) large cohort individuals affected...
The onset of psychosis is the consequence complex interactions between genetic vulnerability to and response environmental and/or maturational changes. Epigenetics hypothesized mediate interplay genes environment leading psychosis. We believe we performed first longitudinal prospective study genomic DNA methylation during psychotic transition in help-seeking young individuals referred a specialized outpatient unit for early detection enrolled 1-year follow-up. used Infinium...
BackgroundA key clinical challenge in the management of individuals at high risk for psychosis (CHR) is that it difficult to predict their future outcomes. Here, we investigated if levels circulating molecular lipids are related adverse outcomes this group.MethodsSerum lipidomic analysis was performed 263 CHR and 51 healthy control subjects, who were then clinically monitored up 5 years. Machine learning used identify lipid profiles discriminated between subgroups subjects with distinct...
Abstract Cognitive impairment is a core feature of schizophrenia which precedes the onset full psychotic symptoms, even in ultra-high-risk stage (UHR). Polygenic risk scores (PRS) can be computed for many psychiatric disorders and phenotyping traits, including resilience. We explored correlations between several PRS neurocognition UHR individuals. included 107 individuals; 29.9% them converted to psychosis (UHR-C) while 57.0% did not (UHR-NC) during 1-year follow-up. performances were...
The biological processes associated with the onset of schizophrenia remain largely unknown. Current hypotheses favor gene × environment interactions as supported by our recent report about DNA methylation changes during psychosis. Here, we conducted first longitudinal transcriptomic analysis blood samples from 31 at-risk individuals who later converted to psychosis and 63 did not. Individuals were followed for a maximum 1 year. Blood collected at baseline end follow-up served their own...
Background Adult rats exposed to methylazoxymethanol (MAM) at embryonic day 17 (E17) consistently display behavioral characteristics similar that observed in patients with schizophrenia and replicate neuropathological findings from the prefrontal cortex of psychotic individuals. However, a systematic analysis hippocampal formation thalamus these is lacking. It also unclear if reelin, protein associated potentially involved mechanism action MAM, participates effects this compound. Therefore,...