A5020839983- Neurogenesis and neuroplasticity mechanisms
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Prion Diseases and Protein Misfolding
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Biosimilars and Bioanalytical Methods
- Cardiac Health and Mental Health
- Pluripotent Stem Cells Research
- Neutropenia and Cancer Infections
- Phosphodiesterase function and regulation
- Antibiotics Pharmacokinetics and Efficacy
- Blood disorders and treatments
- Treatment of Major Depression
- Bipolar Disorder and Treatment
- Circadian rhythm and melatonin
- Autism Spectrum Disorder Research
- Amino Acid Enzymes and Metabolism
- Cardiac pacing and defibrillation studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Diabetes Treatment and Management
- Receptor Mechanisms and Signaling
- Pharmacological Effects and Toxicity Studies
- Sleep and related disorders
Penn State Milton S. Hershey Medical Center
2015-2024
Pennsylvania State University
2021
Hexal (Germany)
2018-2019
Délégation Paris 5
2009-2018
Inserm
2009-2018
Université Paris Cité
2009-2018
Centre Hospitalier Sainte-Anne
2009-2018
Centre National de la Recherche Scientifique
2018
Sorbonne Paris Cité
2018
Institut de Psychiatrie et Neurosciences de Paris
2009-2018
Abstract The inaccessibility of neurons coming directly from patients has hindered our understanding mental illnesses at the cellular level. To overcome this obstacle, six different approaches that carry genetic vulnerability to psychiatric disorders are currently available: Olfactory Neuroepithelial Cells, Mesenchymal Stem Pluripotent Monocytes, Induced Neuronal cells and more recently Brain Organoids. Here we contrast advantages disadvantages each these cell-based methodologies....
Over the past two decades, suicide has consistently ranked among leading causes of death in United States. While deaths are closely associated with uicidal ideation and attempts, these not good predictors future deaths. Establishing who is at risk remains a challenge that mostly hampered by lack understanding its pathophysiology. Nonetheless, evidence continues to accumulate suggesting driven complex dynamic interaction between environmental factors genetics. The identification genes place...
The presence of pathogenic prion protein (PrP(Sc)) in lymphoid tissues variant Creutzfeldt-Jakob disease (vCJD) patients raises questions as to whether prions may be present bodily fluids well. Currently, transgenic mice are highly sensitive vivo tools for the study or containing high levels normal (PrP(C)). We report here an vitro assay with virtually equivalent sensitivity incorporating a capture antibody into sandwich conformation-dependent immunoassay (CDI), resulting 30- 100-fold...
Abstract The long lapse between the presumptive origin of schizophrenia (SCZ) during early development and its diagnosis in late adolescence has hindered study crucial neurodevelopmental processes directly living patients. Dopamine, a neurotransmitter consistently associated with pathophysiology SCZ, participates several aspects brain including pruning neuronal extensions. Excessive is considered cause most consistent finding namely decreased volume. It therefore possible that patients SCZ...
Abstract: Melatonin increases neurite formation in N1E‐115 cells through microtubule enlargement elicited by calmodulin antagonism and vimentin intermediate filament reorganization caused protein kinase C (PKC) activation. Microfilament rearrangement is also a necessary process growth cone during outgrowth. In this work, we studied the effect of melatonin on microfilament rearrangements present at early stages possible participation PKC Rho‐associated (ROCK), which downstream signaling...
Background Adult rats exposed to methylazoxymethanol (MAM) at embryonic day 17 (E17) consistently display behavioral characteristics similar that observed in patients with schizophrenia and replicate neuropathological findings from the prefrontal cortex of psychotic individuals. However, a systematic analysis hippocampal formation thalamus these is lacking. It also unclear if reelin, protein associated potentially involved mechanism action MAM, participates effects this compound. Therefore,...
Patients with schizophrenia show decreased processing speed on neuropsychological testing and white matter integrity as measured by diffusion tensor imaging, two traits shown to be both heritable genetically associated indicating that there may genes influence well disease risk. The potassium channel gene family is a reasonable candidate harbor such given the prominent role channels play in central nervous system signal transduction, particularly myelinated axons. We genotyped members of...
Aims: Neuronal uncoupling proteins are involved in the regulation of reactive oxygen species production and intracellular calcium homeostasis, thus, play a neuroprotective role. In order to explore potential consequences neuronal variants we examined their association sample Caucasian patients suffering from schizophrenia phenotyped them according antipsychotic response. Materials & methods: Using case–control design, compared frequencies 15 genetic spanning UCP2, UCP4 UCP5 106 French 127...
Despite progress, our understanding of psychiatric and neurological illnesses remains poor, at least in part due to the inability access neurons directly from patients. Currently, there are vitro models available but significant work remains, including search for a less invasive, inexpensive rapid method obtain neuronal-like cells with capacity deliver reproducible results. Here we present new protocol transdifferentiate human circulating monocytes into 20 days without need viral insertion...
Varying initial doses of activated eptacog beta (recombinant human FVIIa, rhFVIIa) may provide therapeutic options when treating bleeding in patients with congenital haemophilia who have developed inhibitory antibodies to factor VIII (FVIII) or IX (FIX). This study evaluated escalated a new rhFVIIa product as prelude selecting the for clinical efficacy evaluation patients.To assess safety, pharmacokinetics, and laboratory pharmacodynamics 3 non-bleeding A B without inhibitors.Adult male...
Deficits in neuronal structure are consistently associated with neurodevelopmental illnesses such as autism and schizophrenia. Nonetheless, the inability to access neurons from clinical patients has limited study of early neurostructural changes directly patients' cells. This obstacle been circumvented by differentiating stem cells into neurons, although most used methodologies time consuming. Therefore, we recently developed a relatively rapid (~20 days) protocol for transdifferentiating...
Background: The development of new treatment alternatives for schizophrenia has been prevented by the unknown etiology illness and divergence results in field. However, consistent neuropathological findings are emerging from anatomical areas known to be at core schizophrenia. If these deficiencies replicated animal models then such anomalies could become target a generation drugs. Objective: To determine if methylazoxymethanol acetate (MAM) model, heterozygote reeler mouse (HRM)...
Abstract Research has yet to provide a comprehensive understanding of the genetic basis bipolar disorder (BP). In studies, defining phenotype by diagnosis may miss risk-allele carriers without BP. The authors aimed test whether quantitatively detected subclinical symptoms bipolarity identifies heritable trait that infers risk for Quantitative Bipolarity Scale (QBS) was administered 310 Old Order Amish or Mennonite individuals from multigenerational pedigrees; 110 had psychiatric diagnoses...
Gabapentin has become increasingly used in psychiatric practice specifically for anxiety disorders. Even though gabapentin is not approved by the US Food and Drug Administration to treat anxiety, physicians sometimes use it as an alternative benzodiazepines patients with a history of substance abuse. also prescribed when individuals are at risk thrombocytopenia which considered side effect. Among those positive human immunodeficiency virus (HIV). Here we present case HIV-positive man who...