A5078659660- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neurogenesis and neuroplasticity mechanisms
- Schizophrenia research and treatment
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Diet and metabolism studies
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Neuroscience of respiration and sleep
- Prenatal Substance Exposure Effects
- Regulation of Appetite and Obesity
- Biochemical Analysis and Sensing Techniques
- Hypothalamic control of reproductive hormones
- Adipose Tissue and Metabolism
- Autism Spectrum Disorder Research
- Parkinson's Disease Mechanisms and Treatments
- Advanced biosensing and bioanalysis techniques
- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- Digital Mental Health Interventions
Jiangxi Agricultural University
2024
Université Paris Cité
2010-2023
Inserm
2009-2023
Institut de Psychiatrie et Neurosciences de Paris
2010-2023
Centre Hospitalier Sainte-Anne
2006-2023
Délégation Paris 5
2006-2015
Sorbonne Paris Cité
2015
Institut National de Recherche en Santé Publique
2007
Descartes (Belgium)
2006
Centre Paul Broca
2003-2006
Engrailed1 and Engrailed 2 ( En1 En2 ) are two developmental genes of the homeogene family expressed in developing midbrain. and, to a lesser degree, also adult substantia nigra (SN) ventral tegmental area (VTA), dopaminergic (DA) nuclei In an effort study En1/2 functions, we have analyzed phenotype mice lacking one allele wild-type context. We show that this mutant number DA neurons decreases slowly between 8 24 weeks after birth reach stable 38 23% reduction SN VTA, respectively, neuronal...
We investigated the cognitive consequences of a prenatal injection mitotic inhibitor methylazoxymethanol (MAM) into pregnant rats at embryonic day 15 (E15) or 17 (E17). The male offspring were tested when adult on version radial-arm maze task that assesses spatial working memory with an extended delay, where performance is dependent, in part, hippocampal–prefrontal circuit. A major impairment learning was observed E15 MAM rats. However, E17 did learn rule but impaired selectively 30-min...
Neonatal ventral hippocampal lesions in the rat result post-pubertal onset of behavioural abnormalities, modelling some aspects schizophrenia. We further assessed effects neonatal rats a variety cognitive tasks and prepulse inhibition (PPI) startle response paradigm. Prepubescent, lesioned exhibited responses PPI similar to controls whereas, at adulthood, they showed deficit PPI. Lesioned acquired both passive active avoidance responses. However, compared controls, retention acquisition In...
Background Adult rats exposed to methylazoxymethanol (MAM) at embryonic day 17 (E17) consistently display behavioral characteristics similar that observed in patients with schizophrenia and replicate neuropathological findings from the prefrontal cortex of psychotic individuals. However, a systematic analysis hippocampal formation thalamus these is lacking. It also unclear if reelin, protein associated potentially involved mechanism action MAM, participates effects this compound. Therefore,...
Exposure to methylazoxymethanol (MAM) at embryonic day 17 (E17) in the rat has been proposed be a promising model for schizophrenia that mimics behavioural abnormalities and deficits prefrontal cortex (PFC) networks. In this study, we investigated first time effects of antipsychotics on abnormal behaviours observed prenatally MAM-exposed rats. We examined spontaneous MK-801-induced locomotor activity an open field adult E17 MAM- or saline-exposed Then, effect single injections haloperidol,...
The OTX2 homeoprotein transcription factor is expressed in the dopaminergic neurons of ventral tegmental area, which projects to limbic structures controlling complex behaviors. also produced choroid plexus epithelium, from it secreted into cerebrospinal fluid and transferred structure parvalbumin interneurons. Previously, adult male mice subjected early-life stress were found susceptible anxiety-like behaviors, with accompanying expression changes area or plexus. Here, we investigated...
The abuse liability of Ro 64-6198, an orphanin FQ (OFQ) receptor full agonist that exhibits anxiolytic properties, was evaluated using unbiased conditioned place preference (CPP) paradigm in rats. As OFQ is structurally related to opioid peptides and also anxiolytic-like the effect 64-6198 on CPP compared with those morphine alprazolam. We show here neither nor alprazolam exhibited rewarding or aversive whereas induced a pronounced CPP. These results strengthen previous finding lacked...
THE rewarding and locomotor effects of the specific dopamine uptake inhibitor GBR12783 (2.5–20 mg kg−1, i.p.) were compared with those cocaine. For both drugs, all doses produced a conditioned place preference (CPP), even dose 2.5 which did not modify activity. Despite an equivalent stimulation, magnitude CPP induced by cocaine (10 kg−1) was greater than that same GBR12783. This confirms involvement inhibition in reward, but underlines differences relative efficacies motor drugs suggests...
Memantine, a noncompetitive N-methyl-D-aspartate receptor antagonist, has been approved for use in Alzheimer's disease, but an increasing number of studies have investigated its utility neuropsychiatric disorders. Here, we characterized novel compound, fluoroethylnormemtantine (FENM), which was derived from memantine with extra Fluor optimized position vivo biomarker labeling. We sought to determine if FENM produced similar behavioral effects as and/or beneficial against fear, avoidance, and despair.
Cajal-Retzius cells (CRs) are a class of transient neurons in the mammalian cortex that play critical role cortical development. Neocortical CRs undergo almost complete elimination first two postnatal weeks rodents and persistence during life has been detected pathological conditions related to epilepsy. However, it is unclear whether their cause or consequence these diseases. To decipher molecular mechanisms involved CR death, we investigated contribution PI3K/AKT/mTOR pathway as plays cell...
The conditioned place preference (CPP) induced by increasing doses (1.25-40 mg/kg) of cocaine or the specific dopamine uptake inhibitor GBR12783 was investigated in rats previously treated with (10 20 mg/kg), morphine for 15 days. In solvent-pretreated rats, cocaine- and GBR12783-induced CPPs were biphasic, highest scores observed at mg/kg. Prior exposure to sensitized rewarding effects low either cocaine. Pretreatment mg/kg, but not 10 its own effects. Furthermore, it less efficient than...