A5002578610- Stroke Rehabilitation and Recovery
- Botulinum Toxin and Related Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Motor Control and Adaptation
- Cerebral Palsy and Movement Disorders
- Advanced Neuroimaging Techniques and Applications
- Muscle activation and electromyography studies
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Musculoskeletal pain and rehabilitation
- Psychosomatic Disorders and Their Treatments
- Vestibular and auditory disorders
- Action Observation and Synchronization
- Spinal Cord Injury Research
- EEG and Brain-Computer Interfaces
- Tactile and Sensory Interactions
- Cervical and Thoracic Myelopathy
- Schizophrenia research and treatment
- Ergonomics and Musculoskeletal Disorders
- Multiple Sclerosis Research Studies
- Attention Deficit Hyperactivity Disorder
- Acute Ischemic Stroke Management
- Peripheral Nerve Disorders
- Neuroscience and Music Perception
- Neurobiology of Language and Bilingualism
Institut de Psychiatrie et Neurosciences de Paris
2015-2024
Université Paris Cité
2015-2024
Inserm
2015-2024
Karolinska Institutet
2011-2024
Délégation Paris 5
2013-2022
Danderyds sjukhus
2003-2021
Sorbonne Paris Cité
2011-2021
Centre National de la Recherche Scientifique
2011-2020
Center for Neurosciences
2018
Centre Hospitalier Sainte-Anne
2017
Thirteen patients with healthy hearts and lungs, a mean age of 68 years, who were scheduled for lower abdominal surgery during isoflurane anaesthesia muscular paralysis, investigated arterial blood gases, spirometry, pulmonary x‐ray computed tomography (CT) the chest before anaesthesia, as well first 4 postoperative days. Before lung function gas exchange normal in all patients. Pulmonary CT scans lungs also normal. During 6 13 developed atelectasis (mean 1.0% intrathoracic transverse area...
Background. There is no easy and reliable method to measure spasticity, although it a common important symptom after brain injury. Objective. The aim of this study was develop validate new spasticity that can be easily used in clinical practice. Methods. A biomechanical model created estimate the components force resisting passive hand extension, namely ( a) inertia (IC), b) elasticity (EC), c) viscosity (VC), d) neural (NC). validated chronic stroke patients with varying degree spasticity....
Manual dexterity measures can be useful for early detection of age-related functional decline and prediction cognitive decline. However, what aspects sensorimotor function to assess remains unclear. markers should able separate impairments related from those healthy aging. In this pilot study, we aimed compare manual components in patients diagnosed with (mean age: 84 years, N=11) age comparable cognitively intact elderly subjects 78 N=11). order due aging deficits also included two groups...
Objective: To determine which individual and work-related factors are associated with performing modified work to evaluate the influence of on duration sick leave health-related outcomes among employees musculoskeletal complaints.Study design: A prospective study 12 months follow-up.Methods: In this a total 164 for 2-6 weeks due complaints completed 2 questionnaires.At baseline we gathered information about characteristics, physical psychosocial workload, disease specific general health.The...
A high degree of manual dexterity is a central feature the human upper limb. rich interplay sensory and motor components in hand fingers allows for independent control terms timing, kinematics force. Stroke often leads to impaired function decreased dexterity, limiting activities daily living impacting quality life. Clinically, there lack quantitative multi-dimensional measures dexterity. We therefore developed Finger Force Manipulandum (FFM), which quantification key The purpose this study...
To describe the reliability of an instrument (Neuro- Flexor) designed to be used in clinic for quantification relative contribution spasticity, elasticity and viscosity resistance during passive wrist movements.A test-retest inter-rater study.A convenience sample 34 adults with chronic stroke spasticity hand, a reference group 10 healthy persons.Two raters assessed participants NeuroFlexor. Elastic, viscous neural components movement were quantified at wrist. Test-retest intraclass...
Objective: This longitudinal observational study investigated how neural stretch-resistance in wrist and finger flexors develops after stroke relates to motor recovery, secondary complications, lesion location. Methods: Sixty-one patients were assessed at 3 weeks (T1), three (T2), 6 months (T3) using the NeuroFlexor method clinical tests. Magnetic Resonance Imaging was used calculate weighted corticospinal tract load (wCST-LL) perform voxel-based symptom mapping. Results: assessment...
To determine similarities and differences in key predictors of recovery bimanual hand use unimanual motor impairment after stroke.In this prospective longitudinal study, 89 patients with first-ever stroke arm paresis were assessed at 3 weeks 6 months onset. Bimanual activity performance was the Adult Assisting Hand Assessment Stroke (Ad-AHA), Fugl-Meyer (FMA). Candidate included shoulder abduction finger extension measured by corresponding FMA items (FMA-SAFE; range 0-4) sensory cognitive...
This study tested the hypothesis that degeneration of corticofugal tracts (CFTs) is related to poor functional outcome in upper limb after stroke.. The authors used diffusion tensor imaging determine degree white matter integrity CFT (FA(AH/UH)) chronic stroke patients and controls. corticospinal pathway was examined using transcranial magnetic stimulation. Recruitment curves silent period duration were measured. relationship between FA(AH/UH) also assessed a battery function tests.In...
Objective. To examine whether cerebral activity during passive movements decreases with time after stroke, and if reduced in the representation for upper extremity can be reversed training. Methods. Brain was measured by functional magnetic resonance imaging (fMRI) wrist flexion-extension 7 patients at varying points a cross-sectional design. Upper limb function also all patients. Five of took part training program were again, behaviorally fMRI posttraining. Healthy control individuals...
Diffusion tensor imaging (DTI) can be used to elucidate relations between CNS structure and function. We hypothesized that the degree of spinal white matter organization relates accuracy control grip force. Healthy subjects different age were studied using DTI visuomotor tracking precision The latter is a prime component manual dexterity. A regional analysis [fractional anisotropy (FA)] across multiple cervical levels (C2–C3, C4–C5, C6–C7) in regions interest (left right lateral or medial...
The NeuroFlexor objectively quantifies the neural, elastic and viscous components of passive movement resistance in wrist finger flexor muscles. In this study we investigated sensitivity to changes spasticity induced by treatment with botulinum toxin type A (BoNT-A).Prospective observational design.A convenience sample 22 adults post-stroke upper limb scheduled for treatment.BoNT-A was given according individual plans. assessments were made before 4 12 weeks after.At group level, decreased...
Impairments in attentional, working memory and sensorimotor processing have been consistently reported schizophrenia. However, the interaction between cognitive impairments underlying neural mechanisms remains largely uncharted. We hypothesized that altered attentional patients with schizophrenia, probed through saccadic inhibition, would partly explain impaired control be reflected as task-dependent modulation of cortical excitability inhibition. Twenty-five stabilized 17 unaffected...
Background Knowing how impaired manual dexterity and finger proprioception affect upper limb activity capacity is important for delineating targeted post-stroke interventions recovery. Objectives To investigate whether explain variance in capacity, they more than conventional clinical assessments of sensorimotor impairments. Methods Activity hand impairments were assessed using measures N = 42 late subacute/chronic hemiparetic stroke patients. Dexterity was evaluated the Dextrain...
The NeuroFlexor is a novel instrument for quantification of neural, viscous and elastic components passive movement resistance. aim this study was to provide normative data cut-off values from healthy subjects use these explore signs spasticity at the wrist fingers in patients recovering stroke. 107 (age range 28–68 years; 51 % females) 39 stroke 33–69 33 females), 2–4 weeks after stroke, were assessed with NeuroFlexor. Cut-off based on mean + 3SD reference calculated. In patients, modified...
Background and Purpose- Dexterous object manipulation, requiring generation control of finger forces, is often impaired after stroke. This study aimed to describe recovery precision grip force stroke determine clinical imaging predictors 6-month performance. Methods- Eighty first-ever patients with varying degrees upper limb weakness were evaluated at 3 weeks, months, 6 months Twenty-three healthy individuals comparable age also studied. The Strength-Dexterity test was used quantify index...
Objective: Aphasia and apraxia of speech (AOS) after stroke frequently co-occur with a hand motor impairment but few studies have investigated recovery across speech-language domains. In this study, we set out to test the shared hypothesis. We aimed (1) describe prevalence AOS aphasia in subacute patients (2) compare addition, also explored factors predicting from AOS. Methods: Seventy participants mild severe paresis upper extremity were assessed; 50% these ( n = 35) had left hemisphere...