Colistin is an old antibiotic used in the treatment of Gram-negative infections. It was once suspended because its nephrotoxic effect but has since been reintroduced due to multidrug-resistant bacterial The pathogenesis colistin-associated nephropathy not clarified, and there currently no effective therapeutic or prophylactic agent available. aim this study investigate roles caspase-associated apoptosis caspase 1, calpain inducible nitric oxide synthase (iNOS), endothelial (eNOS) expression...

Previous research has shown daily salt intakes in Turkey to be far above the recommended limits. Knowing sources of dietary could form a basis for preventive strategies aimed towards reduction. This study investigate Turkey. A sub-group (n = 657) was selected from PatenT2 population, which represented urban and rural areas 4 major cities (Ankara, Istanbul, Izmir, Konya). questionnaire inquiring about sociodemographic characteristics, medical histories, detailed histories diet, consumption...

<b><i>Aim:</i></b> Contrast-induced nephropathy (CIN) is a common cause of hospital-acquired acute renal failure. Although it so common, there has been no approved therapy yet. We aimed to investigate the effect grape seed<b> </b>proanthocyanidin extract (GSPE) on preventing CIN. <b><i>Materials and Methods:</i></b> 24 rats were divided into four groups as control group, GSPE contrast medium (CM) CM+GSPE group. The experiment was...

Objectives: Cyclosporine A (CsA) is an immunosuppressive drug, but cardiotoxicity one of its side effects. Free oxygen radical damage and apoptosis are considered to be responsible for CsA-induced cardiotoxicity. Grape seed proanthocyanidin extract (GSPE) displays antioxidant antiapoptotic activities. Therefore, we aimed evaluate the effect GSPE on Materials methods: Twenty-four rats were divided into four groups, with six in each group. nephropathy was induced by administration 25 mg/kg...

Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) a molecule with anti-oxidant anti-apoptotic properties. Our aim was demonstrate effects GSPE in preventing CsA nephropathy.Twenty-four Sprague-Dawley rats were divided into four groups. The control, GSPE, CsA+GSPE groups given 1 mL olive oil, 100 mg/kg 25 GSPE+25 CsA, respectively. On day 21, blood samples taken...

Hypertension is associated with an increase in platelet activation and endothelial dysfunction leads to a tendency cardiovascular events (CVEs). Signal peptide-CUB-EGF domain–containing protein 1 (SCUBE1) novel marker. There are currently no studies showing the level of SCUBE1 hypertensive patients. The purpose this study was determine patient group investigate parameters affecting that level. Forty-five newly diagnosed, untreated, stage patients 21 healthy individuals were included. Blood...

Objective We aimed to investigate the association of fragmented QRS (fQRS) with subclinical left ventricular (LV) dysfunction in patients chronic kidney disease (CKD).Methods and results Patients CKD who had a normal LV ejection fraction (≥ 50%) were enrolled. The tissue Doppler-derived Tei index was measured for all patients. A ≥ 0.5 considered abnormal. Subclinical defi ned as presence an abnormal absence impaired (< 50%). fQRS additional R wave (R’) or notching S fragmentation two...

Abstract No consensus has emerged among different guidelines concerning how many blood pressure (BP) measurements should be performed at office visits in the diagnosis of hypertension. The purpose this study was to examine compatibility various multiple average BP and 24‐h monitoring (ABPM) patients followed up posthoc analysis Cappadocia hypertension cohort. A total 1158 by 207 were examined. results then classified as G1 (average 1 st 2 nd BP), G2 3 rd ), G3 , 4 th G4 2nd, 3rd, 5 G5 all...

Background. Quantitative ultrasound (QUS) of bone is a relatively new technique that appears to assess 'bone quality' in addition mineral density. The purpose this study was evaluate the diagnostic potential QUS calcaneum and correlate it with dual energy X‐ray absorptiometry (DEXA) chronic haemodialysis patients.

Amikacin is a commonly used antibacterial drug that can cause significant nephrotoxic effects in both humans and experimental animals. It has been reported one mechanism of the toxic aminoglycoside antibiotics are result oxidative reactions. The aim this study to examine N-acetylcysteine, thiol-containing antioxidant, on renal function (serum creatinine) morphology (renal tubular damage) mice subjected amikacin-induced nephrotoxicity. A total 32 were equally divided into four groups injected...

Nephrotoxicity induced by aminoglycosides (AGs) limits their clinical use. As yet, no molecules have been approved to prevent AG nephropathy. We aim investigate the effectiveness of grape seed proanthocyanidin extract (GSPE) in prevention amikacin (AK)-induced nephrotoxicity.A total 24 rats were allocated into control, GSPE, AK, and AK + GSPE groups. While 1 mL saline was administered for 6 days control groups, 100 mg/kg On day 7, intraperitoneal (i.p.) while 1.2 g/kg i.p. The experiment...

Acute kidney injury (AKI) is a major cause of mortality and morbidity in hospitalized patients. Incidence rates vary from country to country, according different in-hospital monitoring units definitions AKI. The aim this study was determine factors affecting frequency AKI our hospital. We retrospectively evaluated data for 1550 patients diagnosed with 788 meeting the Kidney Disease: Improving Global Outcomes (KDIGO) guideline criteria out total 174 852 institution between January 1, 2007...

Abstract The aim of this study was to evaluate the effects adipocytokines including adiponectin, leptin, resistin, neuropeptide Y and ghrelin in chronic kidney disease ( CKD ) patients on appearance protein‐energy wasting PEW ). One hundred fifty with mean age 45.4 ± 15.9 years, without active infections or inflammatory conditions were recruited into study. Study groups control group (consisting 30 healthy volunteers normal functions), hemodialysis group, predialysis peritoneal dialysis...

Complex mechanisms including genetic factors have been proposed in the pathogenesis of primary hypertension (HT). Micro RNAs (miRNAs) are single-stranded RNA molecules that not converted into protein products. However, it has established genes regulate conversion The aim this study was to investigate roles miRNA 4516, 145, 24, and 181a HT. secondary relation between these miRNAs renin, aldosterone, norepinephrine, renalase, NOS. Fifty-two hypertensive 51 control normotensive individuals...

The purpose of this study was to assess the role caspase-dependent apoptosis, caspase 1, calpain inducible nitric oxide synthase (iNOS) and endothelial (eNOS) protective effect grape seed proanthocyanidin extract (GSPE) in development rhabdomyolysis-induced acute kidney injury (AKI).Twenty-one rats were divided into 3 groups - control, rhabdomyolysis + GSPE. Rhabdomyolysis induced GSPE with injection both hind limbs 10 ml/kg hypertonic (50%) glycerol following 24-hour dehydration on 6th day....

Abstract BACKGROUND Blood pressure variability (BPV) is associated with end organ damage and cardiovascular outcomes in hypertensive patients. Prehypertensive patients frequently develop hypertension (HT). The purpose of the present study was to evaluate effect BPV on development HT. METHODS Two hundred seven prehypertensive from Cappadocia cohort were monitored over 2 years, 24-hour ambulatory blood monitoring (ABPM), office BP, home BP measurements subsequently performed at 4- 6-month...

Many possible causes of resistance to human recombinant erythropoietin (rh-EPO) have been reported in patients with renal failure. This case presents an unusual cause erythropoietin-resistant anemia a patient chronic A 61-year-old male who was on hemodialysis program due diabetic nephropathy for seven months developed resistant anemia. No iron deficiency revealed by laboratory data, no megaloblastic were found biochemical investigation, and inflammatory states including infection or...

Hypertension is frequently seen in autosomal dominant polycystic kidney disease (ADPKD), and it has a negative effect on renal progression. left ventricle hypertrophy (LVH) are related terms of pathogenesis their effects In this study, we aimed to compare the losartan ramipril blood pressure (BP) control, LVH, progression patients with hypertensive ADPKD.Thirty-two ADPKD ages ranging between 18 70 years who were stage 1-2 included study. Routine biochemical tests echocardiography obtained at...