Chronic inflammation is a common feature of end-stage renal disease, which carries heightened risk atherosclerosis and other co-morbid conditions. Dialysis treatment per se can bring additional factors for inflammation, such as increased local graft fistula infections, impure dialysate or bio-incompatible membranes. Our study was designed to determine whether hemodialysis session leads an acute substantial alteration in the plasma levels proinflammatory cytokines interleukin (IL)-6, IL-1beta...

Background Recently, it has been reported that urinary angiotensinogen levels is a specific index of the intrarenal renin-angiotensin-aldosterone system (RAAS) status and significantly correlated with albumin:creatinine (Cr) ratio in hypertensive patients. The aim present study was to assess effect activation Vitamin D receptor calcitriol on albuminuria as novel biomarker intra-renal RAAS patients diabetic nephropathy (DN). Methods Ninety-eight type 2 diabetes who were treated inhibitors...

Background. Quantitative ultrasound (QUS) of bone is a relatively new technique that appears to assess 'bone quality' in addition mineral density. The purpose this study was evaluate the diagnostic potential QUS calcaneum and correlate it with dual energy X‐ray absorptiometry (DEXA) chronic haemodialysis patients.

Only scarce data are available on chronic copper poisoning in general toxicology literature. This paper reports four patients with and one patient acute poisoning. The cases our study consisted of members a farmer family presenting to the emergency department (ED) malaise, weakness, abdominal pain, headache, dizziness, tightness chest, leg back accompanied by significant anemia (hemoglobin [Hb]: 8.7 - 9.5 g/dl). They were hospitalized investigated thoroughly, although there no other findings...

Cardiac markers are more likely to be elevated in dialysis patients than with renal failure not on dialysis. In this study, 31 (20 males, 11 females) undergoing chronic haemodialysis were enrolled. The effect of cardiac troponin T (cTnT), I (cTnI), creatine kinase MB (CKMB) mass, CKMB activity and myoglobin assays was assessed by comparing pre- post-haemodialysis determinations. After correcting for haemoconcentration, significant differences observed (mean +/- SEM, vs post-dialysis) (178.9...

SUMMARY: Objectives: Atherosclerotic vascular disease is the most frequent complication seen in haemodialysis (HD) patients. Evidence suggests that inflammation may play a role pathogenesis and progression of atherosclerosis. Our aim was to evaluate causative atherosclerosis among HD Methods: Intima‐media thickness (IMT) carotid arteries determined 54 patients 52 controls. Plasma levels lipids, glucose, albumin several acute phase proteins, immunoglobulin G titres against chlamydia...

(Echocardiography 2010;27:E115‐E116)

Regulation of the fibrinolytic balance between plasminogen activators and inhibitors is modulated by renin-angiotensin system (RAS). Impaired function, characterized increased activator inhibitor type 1 (PAI-1) levels decreased tissue (t-PA) activity, has been found in patients with hypertension may account part for risk atherosclerosis its clinical complications these patients. In this regard, data from literature indicate that different antihypertensive drugs vary their influence on...

Compliance with the prescribed medical regimen is a critical factor for continued well-being of hemodialysis patients. As compliance multifactorial problem, numerous approaches have been utilized to quantify In present study, we attempted examine whether unanticipated control biochemical indices might predict status We compared mid-month values blood urea nitrogen (BUN), serum potassium (K) and phosphate (PO<sub>4</sub>) 54 maintenance patients scheduled, regular first-week...

Henoch-Schönlein purpura (HSP) is a form of systemic vasculitis involving both arterioles and capillaries. HSP frequently seen in children between the ages 2 11 years, though adults with this disease are occasionally encountered. Although it primarily early childhood, can occur at any age. The clinical manifestations include classic tetrad: rash, arthralgias, abdominal pain renal disease. However, may affect almost other bodily tissue, such as myocardium, lungs, ureter nervous system....

The renin—angiotensin—aldosterone system (RAAS) plays a central role in fibrinolysis. Activation of the RAAS stimulates expression plasminogen activator inhibitor-1 (PAI-1), which can be directly implicated pathophysiology thromboembolic events. Our primary aims were to measure (1) effect acute activation on plasma levels PAI-1, and (2) inhibitory an angiotensin-converting enzyme (ACE) inhibitor alone, versus combination ACE aldosterone blockade increase PAI-1 usually observed. In current...

ABSTRACT: Aim: A possible link between the renin–angiotensin–aldosterone system (RAAS) and fibrinolysis has recently been suggested. Systemic infusion of angiotensin II results in an increase plasminogen activator inhibitor type 1 (PAI‐1) levels angiotensin‐converting enzyme inhibitors (ACEI) have shown to decrease PAI‐1 levels. Moreover, recent data indicated that plasma aldosterone were positively correlated with This study was designed compare effects ACEI combination antagonist on...

In this study, we primarily aimed to identify the acute effects of hypertension on fibrinolytic function in previously untreated urgent hypertensive patients and evaluate influence two commonly used, short-acting, anti-hypertensive agents, captopril nifedipine, these patients. Patient groups were selected homogeneously, i.e., only amidst an episode having no co-morbid disease included–and randomly assigned receive either or nifedipine for immediate management. These treatment matched age,...

Exaggerated erythropoietin (EPO) response to phlebotomy regardless of the baseline EPO levels have been shown in patients with post-transplant erythrocytosis (PTE) and administration angiotensin-converting enzyme inhibitors (ACE-1) seems be effective controlling PTE. However, mechanism this ACE-1 induced reduction haematocrit (Hct) is not well known. Although some authors suggested that may reduce secretion, still controversial. The aim present study was assess effect a single dose on...

Background. Angiotensin II (ang II) receptor subtype I binding sites has been recently demonstrated on bone cell precursors. Ang stimulates DNA and collagen synthesis in human adult cells. The aim of this study is to evaluate the role renin angiotensin system metabolism address genetic influence converting enzyme (ACE) gene polymorphism mass hemodialysis patients. Methods. Forty‐eight end‐stage renal disease patients (28 male, 20 female mean age 42 ± 13 years,) maintenance were included...

Background. Thrombopoietin (Tpo) is a recently cloned growth factor which plays critical role in the regulation of thrombopoiesis. Tpo has also been shown to stimulate vitro and vivo erythroid cell growth. Although transcripts were detected hepatocytes, proximal tubules endothelium, mechanisms regulating level circulating have not fully delineated. Changes vessel wall blood flow arteriovenous fistula (AVF) might alter activity. Methods. Serum thrombopoietin levels serum erythropoietin...