Colistin is an old antibiotic used in the treatment of Gram-negative infections. It was once suspended because its nephrotoxic effect but has since been reintroduced due to multidrug-resistant bacterial The pathogenesis colistin-associated nephropathy not clarified, and there currently no effective therapeutic or prophylactic agent available. aim this study investigate roles caspase-associated apoptosis caspase 1, calpain inducible nitric oxide synthase (iNOS), endothelial (eNOS) expression...

D-limonene is a widely used flavouring additive in foods, beverages and fragrances due to its pleasant lemon-like odour. This study aimed investigate the effects of on central nervous system when subjected chronic restraint stress rats for 21 days. Forty were randomly divided into five groups: i) control, ii) D-limonene, iii) stress, iv) stress+D-limonene v) stress+fluoxetine. Following induction sucrose preference test, open field novel object recognition test forced swimming performed. The...

D‐Limonene is a monoterpene compound that widely contained in citrus plants. It has been demonstrated to have several beneficial properties. The present study aimed investigate the effect of D‐limonene against indomethacin‐induced gastric ulceration. was administered orally for 21 days. Gastric ulceration induced by oral administration 25 mg/kg indomethacin via gavage, five minutes after Lim or ranitidine. stomachs rats were examined macroscopically and histopathologically assess lesions....

<b><i>Aim:</i></b> Contrast-induced nephropathy (CIN) is a common cause of hospital-acquired acute renal failure. Although it so common, there has been no approved therapy yet. We aimed to investigate the effect grape seed<b> </b>proanthocyanidin extract (GSPE) on preventing CIN. <b><i>Materials and Methods:</i></b> 24 rats were divided into four groups as control group, GSPE contrast medium (CM) CM+GSPE group. The experiment was...

Objectives: Cyclosporine A (CsA) is an immunosuppressive drug, but cardiotoxicity one of its side effects. Free oxygen radical damage and apoptosis are considered to be responsible for CsA-induced cardiotoxicity. Grape seed proanthocyanidin extract (GSPE) displays antioxidant antiapoptotic activities. Therefore, we aimed evaluate the effect GSPE on Materials methods: Twenty-four rats were divided into four groups, with six in each group. nephropathy was induced by administration 25 mg/kg...

Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely understood, it attributed to oxidative damage and apoptosis. Grape seed proanthocyanidin extract (GSPE) a molecule with anti-oxidant anti-apoptotic properties. Our aim was demonstrate effects GSPE in preventing CsA nephropathy.Twenty-four Sprague-Dawley rats were divided into four groups. The control, GSPE, CsA+GSPE groups given 1 mL olive oil, 100 mg/kg 25 GSPE+25 CsA, respectively. On day 21, blood samples taken...

Statins, inhibitors of cholesterol synthesis, are used to prevent cardiovascular complications. Moreover, statins have been shown influence some cognitive functions. The modulating effects simvastatin, one member the statin family, on memory-related neurotransmitters and neuronal structures also reported. We aimed investigate behavioral long-term simvastatin application daily activity, psychomotor performance spatial memory using Sprague−Dawley rats. Simvastatin (10 or 30 mg/kg/day) was...

Nephrotoxicity induced by aminoglycosides (AGs) limits their clinical use. As yet, no molecules have been approved to prevent AG nephropathy. We aim investigate the effectiveness of grape seed proanthocyanidin extract (GSPE) in prevention amikacin (AK)-induced nephrotoxicity.A total 24 rats were allocated into control, GSPE, AK, and AK + GSPE groups. While 1 mL saline was administered for 6 days control groups, 100 mg/kg On day 7, intraperitoneal (i.p.) while 1.2 g/kg i.p. The experiment...

The purpose of this study was to assess the role caspase-dependent apoptosis, caspase 1, calpain inducible nitric oxide synthase (iNOS) and endothelial (eNOS) protective effect grape seed proanthocyanidin extract (GSPE) in development rhabdomyolysis-induced acute kidney injury (AKI).Twenty-one rats were divided into 3 groups - control, rhabdomyolysis + GSPE. Rhabdomyolysis induced GSPE with injection both hind limbs 10 ml/kg hypertonic (50%) glycerol following 24-hour dehydration on 6th day....

Statins, inhibitors of cholesterol synthesis for treating dyslipidemia and preventing cardiovascular complications, have been shown to alter central nervous system functions. Our aim was investigate the effects fluvastatin, a member statin family, on psychomotor performance, daily activity spatial memory. Sprague-Dawley rats were treated with fluvastatin (n = 8) or placebo as control 11) regardless sex. Fluvastatin (7.5 mg/kg) administered orally once day four weeks, while group only...

Türkderm-Deri Hastalıkları ve Frengi Arşivi Dergisi, Galenos Yayınevi

In this study, we aimed to explain the role of apelin-13 on body weight, food and water intake with serum leptin, ghrelin, neuropeptid Y (NPY) peptid YY (PYY) levels in male rat. Thirty-two Sprague-Dawley rats were used for study. The injected SP (0.9 %) intraperitoneally (i.p) control group 30 (AP30), 100 (AP100) 300 (AP300) µg/kg study groups, respectively, 10 min before transition dark period, days. During experimental light periods intake, weights recorded rats. Rats euthanized samples...

<i>Aim:</i> The aim of this experimental study is to investigate the foreign body tissue created by meshes that are used for rectopexy. <i>Method:</i> Sixty rats were divided equally into 5 groups. Four mesh types (Surgipro®, Ivalon®, Gore-Tex® and Vypro®) implanted retroperitoneal area except sham group. After a 5-week follow-up period, all animals sacrificed. Specimens evaluated macroscopically using scoring systems biochemically determining hydroxyproline nitric...

Background/aim: This study aims to investigate the association between rs2267437, rs5751129 and rs132770 polymorphisms of XRCC6 gene, which plays a role in repairing DNA double strand breaks, risk Papillary Thyroid Cancer (PTC).Methods: The included 150 patients who had been diagnosed with PTC 204 healthy control subjects. Genotyping SNPs was performed by Polymerase Chain Reaction - Restriction Fragment Length Polymorphism method (PCR RFLP).Results: In rs2267437 polymorphism, individuals GG...

Amaç: Dünyada pandeminin sürdüğü esnada COVID-19’in uzun süreli etkileri rapor edilmeye başlandı ve 12 haftadan süren olgular uzun-covid sendromu olarak ifade edildi. Uzun covid sendromunun en belirgin ifadesi sinir sistemi üzerine gösterdiği belirtilerdi. Bu etkiler sendromuna bağlı “beyin sisi” adlandırıldı. Biz de bu çalışma da COVID-19 geçirmiş bireylerde nörokognitif denetlemeyi amaçladık. Yöntemler: amaçla benzer yaş grubuna sahip, tanı aldıkları tarihten hafta geçmiş geçiren 36...

D-Limonene is a monoterpene compound with anticancer, gastroprotective, anti-inflammatory, antioxidant, anti-nociceptive, and anxiolytic features. In this study, we aimed to investigate the effects of D-limonene under chronic restraint stress in rats. Forty rats were included study randomly divided into 5 groups: i) control, ii) limonene, iii) stress, iv) stress+limonene, v) stress+fluoxetine, respectively. at dose 10 mg/kg was administered orally by gavage along 21 days. At end saline or...

We experimentally studied the effects of H2 receptor blockers (ranitidine) on bacterial translocation (BT) in 42 male albino rats. Sham group (Group I, n = 12 rats) were exposed to 21 degrees C water while Burn II, 15 and Ranitidine III, 95 hot for 10 seconds produce a full thickness burn 30% total body surface area. 300 mg/kg ranitidine was administered Group III starting immediately after injury. Rats sacrificed fifth postburn day. gained weight groups II had significant loss. Gastric pH...