A5010110876- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Dialysis and Renal Disease Management
- Electrolyte and hormonal disorders
- Folate and B Vitamins Research
University of Minnesota Rochester
2024
Vanderbilt University Medical Center
2018
Florida Atlantic University
2018
Maintenance hemodialysis (MHD) patients display significant nutritional abnormalities. Insulin is an anabolic hormone with direct effects on skeletal muscle (SM). We examined the actions of insulin, whole-body (WB), and SM protein turnover in 33 MHD 17 participants without kidney disease using hyperinsulinemic-euglycemic-euaminoacidemic (dual) clamp. Gluteal biopsies were obtained before after dual At baseline, WB synthesis breakdown rates similar patients. During clamp, controls had a...
Metformin is a widely used medication in the management of type 2 diabetes, and its weight-lowering effects involve central nervous system. Growth differentiation factor 15 (GDF15) acts on mid-brain, increased with metformin, positively correlated weight loss. Pituitary hormones can also be altered by metformin states stress. We sought to understand relationship between GDF15 pituitary function use. Data was collected from randomized, double-blinded, cross-over study 9 adult patients...