Many software firms, especially mobile app providers, offer perpetually free basic products to users, but premiums are charged for access the additional features or functionalities. While offering helps capture potential customers, it might cannibalize sales of premium goods services. This paper adopts a game theoretical approach examine impact on competition between two firms in presence network effects. The can either core product and paid service them as bundle. has stand-alone value be...

Cancer cells are immature resulting from cellular reprogramming by gene misregulation, and redifferentiation is expected to reduce malignancy. It unclear, however, whether cancer can undergo terminal differentiation. Here, we show that inhibition of the epigenetic modification enzyme enhancer zeste homolog 2 (EZH2), histone deacetylases 1 3 (HDAC1 -3), lysine demethylase 1A (LSD1), or DNA methyltransferase (DNMT1), which all promote development progression, leads postmitotic neuron-like...

Misexpression of chromatin modification factors and changed epigenetic modifications play crucial roles for tumorigenesis. Our previous studies demonstrated that inhibition enzymes EZH2, LSD1, DNMTs HDACs caused post-mitotic neuron-like differentiation in different cancer cells. However, how they regulate neuronal cells was unknown. Here, we show DNMT1 HDAC1 form interactions themselves, meanwhile, also interact with SMAD proteins β-CATENIN Chemical these leads to reduced level except HDAC1....

Because of its on-demand feature and flexible pay-as-you-go mechanism, cloud service dramatically reduces the up-front information technology expenses that may deter many clients from implementing on-premises software. The associated security risks low customization capability, however, create challenges for adoption service. We study competitive implications capability on consumer purchase choices vendors’ pricing investment strategies. Although services are perceived to be more vulnerable...

Guiding technological progress towards clean innovations is crucial to industrial green transformation. This paper explains how technology innovation affects total factor productivity, using Tobit and panel smooth transition regression (PSTR) models empirically test the relationship between productivity. research shows that has a significantly positive effect on The magnitude of this different in various regions. When intensity environmental regulation reaches particular threshold value...

When confronted with a new product, consumers often find it difficult to predict how will perform, and such uncertainty reduces consumers’ willingness adopt the product. In this paper, we consider market whereby decide when which product buy, given that they know quality of incumbent but are uncertain about entrant. We investigate consumer affects firms’ behavior-based pricing customer acquisition retention dynamics. Using two-period vertical model, that, under high-end encroachment, an...

In this paper, a rotating rectifier fault detection method is proposed and tested, by using the differences between total harmonic distortion (THD) polarity of asynchronous exciter armature current, when works in various conditions. To describe these differences, conception THD, residual sum are used, corresponding functions defined. With functions, can be confirmed. Considering influence interference error measurement, pre-set value employed compared with values residual, functions. Then,...

Kruppel-like factors (Klfs) are a family of transcription consisting 17 members in mammals, Klf1-Klf17, which involved fundamental cellular physiological procedures, such as cell proliferation, differentiation, and apoptosis. However, their functions embryonic development have been poorly understood. Our previous study has demonstrated that the pluripotency factor Klf4 participates germ layer formation axis patterning Xenopus embryos by means regulation key developmental signals. In present...

Cloud services are transforming business and government at an ever-increasing rate. As a form of cloud service, software as service (SaaS) is one the fast growing segments information technology has become attractive alternative to on-premises software. In this paper, we study optimal pricing strategies provider in incumbent-entrant setting under user upgrade cost switching cost. Our results show that equilibrium market structure not unique. The specific segmentation depends on incumbent's...

This study attempts to re-investigate the causal link between bank loans and Peer-to-Peer (P2P) from China using data sets eight areas (i.e., Beijing, Shanghai, Jiangsu, Zhejiang, Shandong, Hubei, Guangdong Sichuan) over 2014M1-2016M4. We apply a bootstrap panel causality analysis that considers both cross-dependency heterogeneity across cities. The empirical results indicate unidirectional Granger running P2P for Zhejiang Shandong; feedback loads Jiangsu only independence other three (i.e. Sichuan).

We adopt the newly developed nonlinear autoregressive distributed lag model, advanced by Shin, Yu and Greenwood-Nimmo [(2014) Modelling asymmetric cointegration dynamic multipliers in a ARDL framework, in: Festschrift Honor of Peter Schmidt, pp. 281–314 (New York: Springer)], to investigate interest rate(IR) pass-through (IRPT) mechanism Taiwan from 1971 M07 2014 M11. find that incomplete IRPT deposit markets shows an adjustment short run symmetric adjustments long run. The rate is rigid...

While previous studies focus on linear unit root test to study the convergence of carbon price in some developed countries and results might be biased due lower power these tests. China provides an interesting arena investigate its fast economic development since inception open door policy late 1970s. In this paper that we use non-linear quantile (in terms Fourier function) China's seven markets over period April 6, 2014 February 17, 2017 Empirical from our demonstrate prices Beijing,...

The essential idea of the element-free Galerkin method (EFG) is that moving least-squares (MLS) approximation are used for trial and test functions with variational principle (weak form). By using weighted orthogonal basis function to construct MLS interpolants, we derive formulae an improved (IEFG) solving three-dimensional problems in linear elasticity. There fewer coefficients (IMLS) than approximation. Also nodes selected entire domain IEFG case conventional EFG method. In this paper, a...

This study focuses on the rotating rectifier fault detection method of wound-rotor synchronous starter-generator (WSSG) with three-phase exciter. Due to difference in topography between traditional DC filed excitation system and exciter, existing for is not effective WSSG. To solve this problem, points out that ratio second fourth harmonic's amplitude fundamental can be used as signature after having analysed harmonic components exciter rotor current which estimated by stator flux under...

Training effective machine learning algorithms requires inhomogeneous data from different sources, which may violate protection regulations. Federated (FedL), emerged as a privacy-aware alternative, enables collaborative model training without accessing the original data. One of key challenges in FedL is how to incentivize clients with huge amounts train on their local datasets. In this paper, we examine pricing by designing incentive schemes under framework, involves platform that publishes...