A5024962111- Telomeres, Telomerase, and Senescence
- Pharmacological Effects of Natural Compounds
- PARP inhibition in cancer therapy
- Sirtuins and Resveratrol in Medicine
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Neurological Disorders and Treatments
- Medicinal Plants and Bioactive Compounds
- Hair Growth and Disorders
- CRISPR and Genetic Engineering
- Mercury impact and mitigation studies
- Advanced biosensing and bioanalysis techniques
- S100 Proteins and Annexins
- DNA and Nucleic Acid Chemistry
- RNA Interference and Gene Delivery
- Vitamin C and Antioxidants Research
- Pluripotent Stem Cells Research
- Iron Metabolism and Disorders
- Plant Molecular Biology Research
- Renal and related cancers
- Liver Disease Diagnosis and Treatment
- Plant-based Medicinal Research
- Endoplasmic Reticulum Stress and Disease
- Heavy Metal Exposure and Toxicity
Southern Medical University Shenzhen Hospital
2024
Jilin University
2021-2023
Academy of Military Medical Sciences
2022
Institute of Microbiology
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Stem cell senescence and depletion are major causes of aging aging-related diseases. The NAD (Nicotinamide adenine dinucleotide) - SIRT1 (Silent Information Regulator 1) PARP1 (Poly (ADP-ribose) polymerase-1) axis has gained interest owing to its significant role in regulating stem organismal aging. A recent study from our lab showed that pre-B-cell leukemia transcription factor1 (PBX1) overexpression attenuates hair follicle-derived mesenchymal cells (HF-MSCs) apoptosis by ROS-mediated DNA...
Tissues and organs undergo structural deterioration functional decline during aging. DNA damage is considered a major cause of stem cell senescence. Although cells develop sophisticated repair systems, when the intrinsic extrinsic insults exceed capacity, cellular senescence, age-related diseases inevitably occur. Therefore, prevention alleviation an alternative to in attenuating senescence preventing diseases. Pre-B-cell leukaemia homeobox 1 (PBX1) participates maintaining pluripotency...
Inflammation and apoptosis play a critical role in the pathological progress of traumatic brain injury (TBI). Isoliquiritigenin is bioactive component extracted from licorice roots, which possesses anti-inflammatory anti-apoptotic properties. This study aims to investigate potential effects isoliquiritigenin on neuroinflammation rat model TBI.The SH-SY5Y cells were subjected cell induced by shear stress effect was measured. Male rats received controlled cortical impact induce TBI then...
Hair follicles (HFs) maintain homeostasis through the hair cycles; therefore, disrupting cycle may lead to loss. Our previous study showed that apoptosis-inducing factor (AIF) nuclear translocation and poly [ADP-ribose] polymerase 1 (PARP1) upregulation induced apoptosis in mouse during transition from anagen catagen. However, mechanism underlying this phenomenon remains unclear. In study, we found intrinsic ROS levels increased follicle catagen, followed by abrupt DNA breaks activation of...
Methylmercury (MeHg) is a toxin that causes severe neuronal oxidative damage. As vitamin C an antioxidant well-known to protect neurons from damage, our goal was elucidate its protective mechanism against MeHg-induced stress in human neuroblastomas (SHSY5Y). We treated cells with MeHg, L-ascorbic acid 2-phosphate (AA2P), or both, and used MTT, flow cytometry, Western blot analyses assess cell found MeHg significantly decreased the survival rate of SH-SY5Y time- dose-dependent manner,...
Serious diseases caused by Streptococcus suis serotype 2 (S. 2) include septicaemia and meningitis, which are associated with high morbidity mortality. Proliferation in the blood can result a breach of blood–brain barrier (BBB) provide entry into cerebrospinal fluid (CSF), where bacteria cause inflammation meningeal membranes resulting meningitis. The molecular mechanisms how this pathogen crosses BBB remain unclear. Suilysin (SLY) has been identified as an important secreted virulence...
Abstract Background: Stem cell senescence and depletion are major causes of organismal aging aging-related diseases. The NAD–SIRT1–PARP1 axis has garnered remarkable interest owing to its significant role in regulating stem aging. Event though our recent study showes that PBX1 overexpression attenuates hair follicle-derived mesenchymal (HF-MSC) apoptosis by ROS-mediated DNA damage via downregulation PARP1 expression, suggesting is a common manifestation the roles both SIRT1 attenuation...