A5018756928- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
Capital Medical University
2022
Beijing Tian Tan Hospital
2022
Peking University
2019
Peking University Cancer Hospital
2019
Abstract ISL1, a LIM-homeodomain transcription factor, serves as biomarker of metastasis in multiple tumors. However, the function and underlying mechanisms ISL1 gastric cancer (GC) have not been fully elucidated. Here we found that was frequently overexpressed GC FFPE samples (104/196, 53.06%), associated with worse clinical outcomes. Furthermore, overexpression loss-of-function influenced cell proliferation, invasion migration vitro vivo, including patient-derived xenograft models. We used...
Abstract Background Gastric cancer (GC) is among the most malignant tumors, yet pathogenesis not fully understood, especially lack of detailed information about mechanisms underlying long non‐coding RNA (lncRNA)‐mediated post‐translational modifications. Here, molecular and clinical significance novel lncRNA syndecan‐binding protein 2‐antisense 1 (SDCBP2‐AS1) in tumorigenesis progression GC were investigated. Methods The expression levels SDCBP2‐AS1 132 pairs adjacent normal tissues...
Purpose: Emerging evidence has shown that long noncoding RNAs (lncRNAs) participate in oncogenesis and tumor progression. We previously found a novel lncRNA p4516 which was closely associated with prognosis by preliminary study of expression profile from paired tumors nontumor tissues 198 gastric cancer (GC) patients. However, the exact biological functions underlying molecular mechanisms tumorigenesis still remain unclear. Materials methods: The RNA fluorescence situ hybridization...