A5014360691- Lung Cancer Treatments and Mutations
- RNA Interference and Gene Delivery
- Intergenerational Family Dynamics and Caregiving
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Lung Cancer Research Studies
- Bone health and treatments
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Advancements in Transdermal Drug Delivery
- Protein Tyrosine Phosphatases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- RNA Research and Splicing
- Pancreatitis Pathology and Treatment
- Health and Wellbeing Research
- Fluorine in Organic Chemistry
- Cancer therapeutics and mechanisms
- Geriatric Care and Nursing Homes
- Liver Disease and Transplantation
- Colorectal Cancer Treatments and Studies
- Osteoarthritis Treatment and Mechanisms
- Cancer Immunotherapy and Biomarkers
- Wnt/β-catenin signaling in development and cancer
- Silk-based biomaterials and applications
Zhengzhou University
2017-2025
Henan Cancer Hospital
2017-2025
Henan Provincial People's Hospital
2021-2025
Northwestern Polytechnical University
2019-2024
University of Hong Kong
2023-2024
Nano and Advanced Materials Institute
2023-2024
Chinese University of Hong Kong
2023
Air Force Medical University
2008-2022
META Health
2022
Wuhan Union Hospital
2021
Rheumatoid arthritis (RA) is an inflammatory immune-mediated disease that can lead to synovitis, cartilage destruction, and even joint damage. Dexamethasone (DEX) a commonly used agent for RA therapy on inflammation manage. However, the traditional administering DEX hampered by low efficiency obvious adverse effects. Therefore, in order efficiently deliver inflamed joints overcome existing deficiencies, we developed transdermal formation dextran sulfate (DS) modified DEX-loaded flexible...
Osteoporosis, a disease characterized by both loss of bone mass and structural deterioration bone, is the most common reason for broken among elderly. It known that attenuated differentiation ability osteogenic cells has been regarded as one greatest contributors to age-related formation reduction. However, effects current therapies are still unsatisfactory. In this study we identify novel long noncoding RNA AK045490 which correlated with enriched in skeletal tissues mice. vitro analysis...
Background: A more accurate assessment of extrahepatic metastases (EHMs) with colorectal cancer liver (CRLMs) improve patient prognosis without unnecessary surgery and economic burden. At present, PET-CT can only be used as a second-line modality. We aimed to construct predictive model for EHMs, provide guidance the selective application 18F-FDG PET/CT. Methods: The clinical data patients CRLMs between December 2018 February 2023 were retrospectively retrieved from medical records three...
BACKGROUND Patients with chronic obstructive pulmonary disease (COPD) frequently experience exacerbations requiring multiple hospitalizations over prolonged courses, which predispose them to generalized anxiety disorder (GAD). This comorbidity exacerbates breathing difficulties, activity limitations, and social isolation. While previous studies predominantly employed the GAD 7-item scale for screening, this approach is somewhat subjective. The current literature on predictive models risk in...
Bone is an especially prone metastatic site for breast cancer, and to block the vicious cycle between bone resorption tumor growth important strategy treatment of cancer metastasis. In this paper, pH- redox-sensitive as well metastasis-targeting nanoparticles (DOX@ALN-(HA-PASP)CL) were prepared, also their anti-tumor activity anti-bone effect investigated in detail. The vitro experimental results indicated that DOX released from DOX@ALN-(HA-PASP)CL exhibited a GSH-, DTT- pH-dependent manner....
This study aimed to investigate the association between serum vitamin C and liver fibrosis in patients with NAFLD US adults.We conducted a cross-sectional analysis of data from 2017 2018 cycle National Health Nutrition Examination Survey (NHANES). Serum transient elastography (TE)-accessed stiffness was taken as independent dependent variables, respectively. Liver steatosis were detected by controlling attenuation parameter (CAP) TE. defined CAP score ≥248 dB/m without any indication other...
Osteoporosis is one of the most common bone disorders that seriously affect health and life quality elderly individuals. Reduced osteoblast differentiation formation lead to changes in volume microarchitecture, leaving bones vulnerable fracture. Bergamottin (BM) a natural compound derived from various citrus fruits possesses multiple biological activities including anti-adipogenesis function. This study aimed evaluate effects BM on its potential anti-osteoporosis capacity, as well explore...
Osteoporosis is a frequently-occurring bone disease in middle-aged and aged men women. However, current therapies on this are still not ideal. miRNA class of endogenous non-protein-coding RNA with length 18-25 nucleotides. have been identified as important regulators for development, metabolism, carcinogenesis formation. miR-129-5p has reported regulator cancer neuroscience, while studies about its function formation limited. In study, we investigated the mechanism osteoblast differentiation...
Alopecia is the most common multifactorial hair loss disorder, affecting almost 50% of population and even having a serious psychological impact on patients. miR-218 has therapeutic potential for alopecia since it can activate Wnt/β-catenin channel by down-regulating SFRP2, which key in follicle cycle transformation regrowth. Although to treat this disease, several barrier properties skin challenge miRNA's delivery target location, such as passing through corneum resistant enzymatic...
Abstract Aging impairs osteoblast function and bone turnover, resulting in age‐related degeneration. Stress granules (SGs) are membrane‐less organelles that assemble response to stress via the recruitment of RNA‐binding proteins (RBPs), have emerged as a novel mechanism diseases. Here, we identified HuR bone‐related RBP aggregated into SGs facilitated osteogenesis during aging. HuR‐positive SG formation increased differentiation, overexpression mitigated reduction observed senescent...
Varicella zoster virus (VZV), which is a human restricted alpha-herpesvirus, causes varicella (chickenpox) and (shingles). The subsequent post-herpetic neuralgia (PHN) due to VZV infection excruciating for most patients. Thus, developing specific therapeutics against imperative. RNA interference (RNAi) represents an effective approach alternative antiviral therapy. This study aimed develop novel anti-VZV based on RNAi.In this study, we screened found the open reading frame 7 (ORF7) of genome...
Chronic obstructive pulmonary disease (COPD) is a chronic airway inflammatory characterised by irreversible airflow limitation. The elderly are vulnerable population for developing COPD. With the growth of age, physiological degenerative changes occur in thorax, bronchus, lung and vascular wall, which can lead to age-related attenuation function elderly, so prevalence COPD increases with age. Its pathogenesis has not yet been truly clarified. Mitophagy plays an important role maintaining...
Abstract Osteoarthritis (OA) is a debilitating joint disease affecting nearly 400 million people with no efficient etiological therapies. OA primarily identified by cartilage destruction, and gradual degeneration of the whole would happen when progresses. Hence, has been as primary therapeutic target OA. Unfortunately, numerous barriers block delivery agents into cartilage, including avascular traits high hardness extracellular matrix. Herein, cartilage‐targeting peptide (CAP) modified...
In order to inhibit the growth of lung cancer bone metastasis and reduce resorption at sites, a target micelle DOX@DBMs-ALN was prepared. The size zeta potential DOX@DBNs-ALN were about 60 nm −15 mV, respectively. exhibited high binding affinity with hydroxyapatite released DOX in redox-responsive manner. effectively up taken by A549 cells delivered nucleus cells, which resulted strong cytotoxicity on cells. vivo experimental results indicated that specifically site obviously prolonged...
// Yu-Ling Sun 1, 2 , Wen-Qi Li Peng-Xu Ding 3 Zhi-Wei Wang Chang-Hua Wei 4 Xiu-Xian Ma Rui-Fang Zhang 5 Yan Wu 6 Lin Zhou 7 Ruo-Peng Liang Yan-Peng Yi-Pu Zhao Rong-Tao Zhu and Jian 1 Department of Hepatobiliary Pancreatic Surgery, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, China Institute Diseases, Radioactive Intervention, Ultrasound Diagnosis, People's Radiology, Digestive Correspondence to: Sun, email: ylsun@zzu.edu.cn Keywords: Budd–Chiari syndrome; gut microbiota;...