Traditional wound dressings mainly participate in the passive healing processes and are rarely engaged active by stimulating skin cell behaviors. Electrical stimulation (ES) has been known to regulate Herein, a series of multifunctional hydrogels based on regenerated bacterial cellulose (rBC) MXene (Ti3 C2 Tx ) first developed that can electrically modulate behaviors for under external ES. The composite hydrogel with 2 wt% (rBC/MXene-2%) exhibits highest electrical conductivity best...

Superhydrophobic surfaces repel water and other liquids such as tissue fluid, blood, urine, pus, which can open up a new avenue for the development of biomedical devices has led to promising advances across diverse fields, including plasma separator devices, blood-repellent sensors, vascular stents, heart valves. Here, fabrication superhydrophobic liquid–solid contact triboelectric nanogenerators (TENGs) their applications droplet sensors are reported. Triboelectrification energy be captured...

Rheumatoid arthritis (RA) is an inflammatory immune-mediated disease that can lead to synovitis, cartilage destruction, and even joint damage. Dexamethasone (DEX) a commonly used agent for RA therapy on inflammation manage. However, the traditional administering DEX hampered by low efficiency obvious adverse effects. Therefore, in order efficiently deliver inflamed joints overcome existing deficiencies, we developed transdermal formation dextran sulfate (DS) modified DEX-loaded flexible...

Abstract Glioma is easy to develop resistance temozolomide (TMZ). TMZ-resistant glioma secretes interleukin-10 (IL-10) and transforming growth factor-β (TGF-β), recruiting regulatory T cell (T reg ) inhibiting the activity of cells natural killer (NK cell), subsequently forming an immunosuppressive microenvironment. Oxaliplatin (OXA) greatly inhibits proliferation cells, but ability OXA cross blood–brain barrier (BBB) weak. Thus, therapeutic effect on not satisfactory. Transferrin receptor 1...

Bone is an especially prone metastatic site for breast cancer, and to block the vicious cycle between bone resorption tumor growth important strategy treatment of cancer metastasis. In this paper, pH- redox-sensitive as well metastasis-targeting nanoparticles (DOX@ALN-(HA-PASP)CL) were prepared, also their anti-tumor activity anti-bone effect investigated in detail. The vitro experimental results indicated that DOX released from DOX@ALN-(HA-PASP)CL exhibited a GSH-, DTT- pH-dependent manner....

A PEG-based, folate mediated, active tumor targeting drug delivery system using DOX-hyd-PEG-FA nanoparticles (NPs) were prepared. NPs showed a significantly faster DOX release in pH 5.0 medium than 7.4 medium. Compared with DOX-hyd-PEG NPs, increased the intracellular accumulation of and translocation from lysosomes to nucleus. The cytotoxicity on KB cells was much higher that free DOX, DOX-ami-PEG-FA NPs. attenuated presence exogenous folic acid. IC50 A549 no significant difference. After...

Abstract In order to overcome drug resistant and enhance antitumor activity of DOX, a new pH-sensitive micelle (DOX/DQA-DOX@DSPE-hyd-PEG-AA) was prepared simultaneously deliver DOX nucleus mitochondria. Drug released from DOX/DQA-DOX@DSPE-hyd-PEG-AA showed pH-dependent manner. induced the depolarization mitochondria apoptosis in MDA-MB-231/ADR cells A549 cells, which resulted high cytotoxicity against cells. Confocal microscopy confirmed that delivered DQA-DOX tumor cell. After injected...

Pharmacotherapy is a treatment for rheumatoid arthritis with limitations, such as poor drug targeting, low effective dosage at the inflammatory site, and high systemic toxicity. The combined application of drug-loaded nanobubbles ultrasound technology provides new technique treatment.

Background Auditory verbal hallucinations (AVH) are a core symptom of schizophrenia, often persisting despite pharmacological treatment. Repetitive transcranial magnetic stimulation (rTMS), particularly low-frequency rTMS targeting the left temporoparietal junction (TPJ), has shown promise in alleviating AVH symptoms by modulating dysfunctional brain connectivity. However, network-level effects remain incompletely understood, terms small-world network properties, which provide insights into...

This study aimed to develop a scale assess the physical activity (PA)-related parenting practices of Chinese parents children aged 3-6 years based on general theory. A pool items (123 items) was constructed literature review and in-depth personal interviews. The pretest (60 developed using Delphi correspondence presurvey. After two rounds item screening exploratory factor analysis (EFA) variance, we deleted 30 items. We ultimately formal version Physical Activity Parenting Practices Scale...

Doxorubicin (DOX) is a broad-spectrum chemotherapy drug to treat tumors. However, severe side effects and development of DOX resistance hinder its clinical application. In order overcome resistance, DOX/TPP-DOX@Pasp-hyd-PEG-FA micelles were prepared by using newly synthesized comb-like amphiphilic material Pasp-hyd-PEG-FA. Drug released in vitro from showed pH-dependent manner. induced more apoptosis KB cell MCF-7/ADR than DOX@Pasp-hyd-PEG-FA. Confocal laser scanning microscopy experiment...

Prostate adenocarcinoma is one of the most prevalent causes cancer-related deaths in males worldwide. However, underlying mechanisms remain poorly understood. Hence, it important to identify specific and effective therapeutic targets, be able determine appropriate therapy management. So, this study aimed predict that miR-93-5p an oncogene prostate cancer by bioinformatics analysis.In study, initially we identified differentially expressed genes (DEGs) differently miRNAs (DEMs) The Cancer...

Alopecia is the most common multifactorial hair loss disorder, affecting almost 50% of population and even having a serious psychological impact on patients. miR-218 has therapeutic potential for alopecia since it can activate Wnt/β-catenin channel by down-regulating SFRP2, which key in follicle cycle transformation regrowth. Although to treat this disease, several barrier properties skin challenge miRNA's delivery target location, such as passing through corneum resistant enzymatic...

A phase change material (PCM) has the characteristics of latent heat storage, controllable transition temperature (PTT), and chemical stability. It can naturally regulate ambient in a certain range reduce load air conditioning operation. Therefore, it plays an important role field energy-saving buildings, PTT PCM is one decisive factors. In this paper, through analyzing installed solar buildings at various regions, binary eutectic mixture (EM) was prepared from lauric acid (LA) octadecanol...

Rheumatoid arthritis (RA) is a chronic, systemic immune disease that causes joint affection and even disability. Activated macrophages play an important role in the pathogenesis progression of RA by producing pro-inflammatory factors. The use dexamethasone (DXM) effective relieving intractable pain inflammatory RA. However, long-term DXM strongly associated with increased rates diabetes, osteoporosis, bone fractures, mortality, which hinders its clinical use. In this study, dextran...

Varicella zoster virus (VZV), which is a human restricted alpha-herpesvirus, causes varicella (chickenpox) and (shingles). The subsequent post-herpetic neuralgia (PHN) due to VZV infection excruciating for most patients. Thus, developing specific therapeutics against imperative. RNA interference (RNAi) represents an effective approach alternative antiviral therapy. This study aimed develop novel anti-VZV based on RNAi.In this study, we screened found the open reading frame 7 (ORF7) of genome...

Osteosarcoma is one of the most common primary malignant tumors bone and tends to develop in teenage years. Although multitreatments for diagnosis therapy osteosarcoma have been developed, there are still needs new methods prevent treat osteosarcoma. Here, we performed bioinformatic analysis screen key genes, molecules, pathways involved survival. Four microarray data sets (GSE99671, GSE87624, GSE65071, GSE28423), which include from human samples, were downloaded Gene Expression Omnibus...

Abstract Background Colon cancer is a most common malignant in digestive system, and it prone to develop resistance the commonly used chemotherapy drugs, leading local recurrence metastasis. Paris saponin VII (PSVII) could not only inhibit proliferation of colon cells but also effectively induce apoptosis drug-resistant reduce metastasis as well. However, PSVII was insoluble water fat. It displayed no selective distribution body cause severe hemolysis. Herein, targeting calcium phosphate...

The experiment aimed to increase the drug-delivery efficiency of poly-lactic-co-glycolic acid (PLGA) nanoparticles. Lipid-polymer hybrid nanoparticles (LPNs-1) were prepared using PLGA as a hydrophobic core and FA-PEG-hyd-DSPE an amphiphilic shell. Uniform spherical with average size 185 nm obtained emulsification solvent evaporation method. results indicated that LPNs-1 showed higher drug loading compared naked (NNPs). Drug release from was faster in acidic environment than neutral...

Convolutional neural networks (CNN) are widely used and effective deep learning methods for image classification tasks. But the architecture of CNN such as LetNet AlexNet were designed elaborately by experts because designing is time-consuming requires expert knowledge. This paper proposed a quantum-inspired evolutionary algorithm to search architectures. First, we encode CNNs into quantum chromosomes distinguish these from Layer, Pooling Fully-connected Layer Disabled with its range....

Abstract A thickener that could address the phase separation problems of sodium acetate trihydrate (SAT) was determined by gravity sedimentation method. Additionally, a hydrated salt nucleating agent to effectively reduce supercooling SAT sought using step‐cooling Combining these findings, new composite change material (SAT CPCM) prepared. sample containing expanded graphite (EG) prepared melt blending enhance thermal conductivity. Our results show with 1.5 % xanthan gum and 2 pyrophosphate...

Bacterial contamination and biofilm formation onpercutaneous implants can lead to device failure be life-threatening. To solve this issue, we constructed a carboxymethyl dextran- (CMD-) based nanomicelle antibacterial coating on the microarc-oxidized titanium (MAO-Ti) surface (described in supplementary file). The self-assembled CMD-based nanomicelles octadecylamine (ODA) were developed as drug carrier loaded with minocycline (MC). characterization stability of MC-loaded determined....