A5033487052- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Parasitic Infections and Diagnostics
- Helminth infection and control
- Parasitic infections in humans and animals
- Atmospheric chemistry and aerosols
- Air Quality and Health Impacts
- Cancer-related Molecular Pathways
- Congenital Anomalies and Fetal Surgery
- Mollusks and Parasites Studies
- Air Quality Monitoring and Forecasting
- Medical and Biological Ozone Research
- Click Chemistry and Applications
- Research on Leishmaniasis Studies
- Mercury impact and mitigation studies
- Molecular Sensors and Ion Detection
- Advanced biosensing and bioanalysis techniques
- Mitochondrial Function and Pathology
- Cancer therapeutics and mechanisms
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- Protein Interaction Studies and Fluorescence Analysis
- Colorectal Cancer Treatments and Studies
- Environmental Toxicology and Ecotoxicology
- Bioactive Compounds and Antitumor Agents
National Institute for Parasitic Diseases
2016-2025
Vector (United States)
2025
Hubei Normal University
2024
Beijing Municipal Ecological and Environmental Monitoring Center
2022-2024
Chengde Medical University
2023-2024
Second Affiliated Hospital of Zhejiang University
2024
Jilin University
2023
Xi'an Jiaotong University
2023
Dali University
2019-2020
Zhengzhou University
2019
Migrasomes are newly discovered cell organelles forming by local swelling of retraction fibers. The migrasome formation critically depends on tetraspanin proteins present in the fiber membranes and is modulated membrane tension bending rigidity. It remained unknown how which time sequence these factors involved nucleation, growth, stabilization, what possible intermediate stages biogenesis. Here using live imaging a biomimetic system for migrasomes fibers, we reveal that two-stage process....
Abstract. Particle acidity is a fundamental property that affects atmospheric particulate chemistry. Synchronous online monitoring was performed at two urban sites, Zhengzhou (U-ZZ) and Anyang (U-AY), three rural (R-AY), Xinxiang (R-XX), Puyang (R-PY) in Henan Province, during haze episode to investigate the pH value its driving factors agricultural regions of China. The values particles calculated by ISORROPIA-II model sites were slightly higher than those with median (min–max) 5.2...
A fluorescence "off-on" probe CBF, constructed by incorporating a dioxaborine unit into microenvironment-sensitive fluorophore, was developed for serum albumin (SA). Upon binding to SA, the group in CBF hydrolyzed β-diketonate, which triggered dramatic enhancement (over 1000-fold) along with remarkable blue-shift (∼100 nm). The bioimaging results suggested that more SA were taken cancer cells.
The golden apple snail Pomacea canaliculata is an invasive pest that causes extensive damage to agricultural production. P. also intermediate host of Angiostrongylus cantonensis, which human eosinophilic meningitis. In this study, the molluscicidal activity and safety profile a novel molluscicide PBQ [1-(4-chlorophenyl)-3-(pyridin-3-yl)urea] were evaluated. exhibited strong potency against adult juvenile snails (LC50 values 0.39 0.07 mg/L, respectively). field trials, killed 99.42% at 0.25 g...
Abstract Pomacea canaliculata is an invasive species that poses significant threats to agriculture and human health. The development of environmentally friendly molluscicides crucial for its management. In this study, we synthesized 17 fluoropyridylphenylurea derivatives using a halogen modulation strategy explore their potential as molluscicides. Compounds L‐1 L‐2 demonstrated notable molluscicidal activity, with LC 50 values 1.377 mg/L 1.001 mg/L, respectively. Among these, exhibited...
Osteoporosis is one of the most common bone disorders that seriously affect health and life quality elderly individuals. Reduced osteoblast differentiation formation lead to changes in volume microarchitecture, leaving bones vulnerable fracture. Bergamottin (BM) a natural compound derived from various citrus fruits possesses multiple biological activities including anti-adipogenesis function. This study aimed evaluate effects BM on its potential anti-osteoporosis capacity, as well explore...
Alveolar echinococcosis (AE) is a lethal parasitic disease caused by infection with the metacestode of dog/fox tapeworm Echinococcus multilocularis, which primarily affects liver. Although continued efforts have been made to find new drugs against this orphan and neglected disease, current treatment options remain limited, drug delivery considered likely barrier for successful treatment.Nanoparticles (NPs) gained much attention in field due their potential improve efficiency targetability....
The snail Biomphalaria straminea is one of the intermediate hosts Schistosoma mansoni. also an invasive species, known for its strong capability on peripheral expansion, long-distance dispersal and colonization. Using molluscicides to control populations important strategy interrupt schistosomiasis transmission prevent spread species. In this study, a series pyridylphenylurea derivatives were synthesized as potential molluscicides. Their impact adult snails egg masses was evaluated. Acute...
Cystic echinococcosis (CE), caused by the cestode Echinococcus granulosus, is a worldwide chronic zoonosis. Current chemotherapeutic options are limited to albendazole and mebendazole, which only exert parasitostatic effects have be administered at high dosages for long periods. In an effort find alternative treatment options, in vitro vivo efficacies of novel carbazole aminoalcohols were evaluated.Carbazole tested against E. granulosus protoscoleces metacestodes ex vivo. The effect...
Schistosomiasis mansoni is one of the most important, but often neglected, tropical diseases transmitted by snails genus Biomphalaria. Control intermediate host snail plays a crucial role in preventing spread schistosomiasis. However, there only molluscicide, niclosamide, recommended World Health Organization. Niclosamide has been used for several decades toxic to non-target organisms. Therefore, it necessary optimize scaffold niclosamide and develop novel molluscicides with enhanced potency...
Despite significant improvements in air quality during and after COVID-19 restrictions, haze continued to occur Zhengzhou afterwards. This paper compares ionic compositions sources of PM2.5 before (2019), (2020), (2021) the restrictions explore reasons for haze. The average concentration decreased by 28.5% 2020 27.9% 2021, respectively, from 102.49 μg m-3 2019. secondary inorganic aerosols (SIAs) was 51.87 2019, which 3.1% 12.8% 2021. In contrast, contributions SIAs increased 50.61% (2019)...
Niemann Pick disease B (NPB) often presents with hepatosplenomegaly and lung pathological changes, but it usually does not present central nervous system symptoms. This report the unique case of a 21-year-old woman 10-year history hard skin hepatosplenomegaly. Genetic sequencing revealed NPB also suggested Segawa syndrome. Although symptomatic supportive treatments were administered in an attempt to improve muscle tone treat sclerosis, their efficacy was satisfactory, patient refused further...
Cystic echinococcosis (CE), a condition caused by the larval stage of dog tapeworm Echinococcus granulosus sensu stricto, is globally distributed zoonotic disease. Current treatment options for CE are limited, and an effective safe anti-echinococcal drug urgently required.
Malaria and schistosomiasis are two of the most socioeconomically devastating parasitic diseases in tropical subtropical countries. Since current chemotherapeutic options limited defective, there is an urgent need to develop novel antiplasmodials antischistosomals. Hemozoin a disposal product formed from hemoglobin digestion by some blood-feeding parasites. formation essential process for parasites detoxify free heme, which reliable therapeutic target identifying antiparasitic agents. A...