A5100413380- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Mitochondrial Function and Pathology
- Cardiac electrophysiology and arrhythmias
- Acupuncture Treatment Research Studies
- Fungal Biology and Applications
- Ion channel regulation and function
- Cardiac Ischemia and Reperfusion
- Natural product bioactivities and synthesis
- Heart Rate Variability and Autonomic Control
- Inflammatory Bowel Disease
- Botulinum Toxin and Related Neurological Disorders
- ATP Synthase and ATPases Research
- Plant-based Medicinal Research
- Cancer survivorship and care
- GABA and Rice Research
- Metabolomics and Mass Spectrometry Studies
- Sirtuins and Resveratrol in Medicine
- Phytochemistry and biological activity of medicinal plants
- Palliative Care and End-of-Life Issues
- Medical Research and Treatments
- Autophagy in Disease and Therapy
- Respiratory and Cough-Related Research
- Chromatography in Natural Products
- Complementary and Alternative Medicine Studies
Guang’anmen Hospital
2011-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2012-2025
Weatherford College
2024
Affiliated Hospital of Jining Medical University
2024
ZheJiang Academy of Agricultural Sciences
2017-2024
Fujian Agriculture and Forestry University
2024
Janssen (United States)
2021-2024
Guiyang University
2022-2024
Shanxi Academy of Medical Sciences
2024
Shanxi Medical University
2024
Objectives: Use of failure-to-rescue (FTR) as an indicator hospital quality has increased over the past decade, but recent authors have used different sets complications and deaths to define this measure. This study examines reliability validity FTR measures currently in use. Research Design: We studied 3 definitions: (1) "original" (using all deaths); (2) FTR-N, a "nursing sensitive" definition that uses only specific deaths; (3) FTR-A [another restricted by Agency for Healthcare Quality...
Abstract We investigated the mechanism by which quercetin preserves mitochondrial quality control (MQC) in cardiomyocytes subjected to ischemia–reperfusion stress. An enzyme‐linked immunosorbent assay was employed vivo experiments assess myocardial injury markers, measure transcript levels of SIRT5/DNAPK‐cs/MLKL during various time intervals ischemia–reperfusion, and observe structural changes using transmission electron microscopy. In vitro investigations, adenovirus transfection establish...
Cleistogamy is a type of self-pollination that relies on the formation stigma-enclosing floral structure. We identify three homeodomain-leucine zipper IV (HD-Zip IV) genes coordinately promote interlocking trichomes at anther margin to unite neighboring anthers, generating closed cone and cleistogamy (flower morphology necessitating strict self-pollination). These HD-Zip also control style length by regulating transition from cell division endoreduplication. The expression these their...
White matter hyperintensities (WMHs), mainly caused by cerebrovascular injury, may lead to cognitive impairment. In order identify whether the volume of WMHs is associated with decline over years, this longitudinal study involved 818 individuals from ADNI-2 dataset August 2010 May 2017. Cross-sectional and associations 8 domains were explored, using Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Clinical Dementia Rating Sum Boxes (CDRSB), Alzheimer Disease...
Objective. Aggressive treatment style, as defined by the Dartmouth Atlas of Health Care, has been implicated an important factor contributing to excessively high medical expenditures. We aimed determine association between aggressive style and surgical outcomes. Data Sources/Study Setting. Medicare admissions 3,065 hospitals for general, orthopedic, vascular surgery 2000 2005 ( N =4,558,215 unique patients). Study Design. A retrospective cohort analysis. Results. For elderly patients, was...
Esophageal cancer patients can experience co-occurring, related symptoms labeled symptom clusters. This study aimed to identify clusters and explore which SCs independently affect the quality of life (QoL) among esophageal patients.This cross-sectional was performed in Shenyang, China, from February 2021 2022. Finally, 118 effectively completed survey. Questionnaires' information included Functional Assessment Cancer Therapy-General (FACT-G), MD Anderson Symptom Inventory Gastrointestinal...
Tumor necrosis factor inhibitors (TNFi) are frequently chosen as the first biologic for patients with psoriatic arthritis (PsA). Given that many PsA TNFi inadequate responders (TNF-IR; either efficacy or intolerance), treatments utilizing alternative mechanisms of action needed. In phase 3 studies, fully human interleukin (IL)-23p19 subunit-inhibitor, guselkumab, was efficacious in active PsA, including TNFi-IR. Efficacy generally consistent between TNFi-naïve and TNFi-experienced cohorts;...
Objectives To evaluate the efficacy through 52 weeks of guselkumab, an interleukin 23-p19 subunit inhibitor, in subgroups pooled psoriatic arthritis (PsA) patients from DISCOVER-1 and DISCOVER-2 trials defined by baseline patient characteristics. Methods Adults with active PsA despite standard therapies were enrolled (≥3 swollen ≥3 tender joints, C reactive protein (CRP) level ≥0.3 mg/dL) (≥5 ≥5 CRP ≥0.6 mg/dL, biological-naïve). Randomised received 100 mg guselkumab at 0, 4, then every 4 or...
To investigate the clinical features and perinatal treatment of thrombocytopenia induced by different causes during pregnancy.Clinical data from 195 pregnant women with attending 2 tertiary hospitals January 2014 to October 2016 were retrospectively studied. The obtained analyzed SPSS 19.0 software.There 117 (60.0%), 55 (28.2%), 23 cases (11.8%) pregnancy-associated (PAT), idiopathic (ITP), hypertensive disorder in pregnancy (PIH), respectively. percentage nulliparous women, gestational age...
Sick sinus syndrome (SSS) is a disease with bradycardia or arrhythmia. The pathological mechanism of SSS mainly due to the abnormal conduction function sinoatrial node (SAN) caused by interstitial lesions fibrosis SAN surrounding tissues, pacing dysfunction, and impulse accompanied fibrosis. Tongyang Huoxue Decoction (TYHX) widely used in treatment amelioration It has variety active ingredients regulate redox balance mitochondrial quality control. This study discusses TYHX ameliorating...
Heart failure refers to a group of clinical syndromes in which various heart diseases lead the inability cardiac output meet metabolic needs body's tissues. Cardiac metabolism requires enormous amounts energy; thus, impaired myocardial energy is considered key factor occurrence and development failure. Mitochondria serve as primary source for cardiomyocytes, their regular functionality underpins healthy function. The mitochondrial quality control system crucial mechanism regulating any...
The quality control processes for herbal medicines have been problematic. Flavonoids are the major active components of Huangqin Tang (HQT, a traditional Chinese medicine formula). In this study, we used combinative method approach consisting chromatographic fingerprinting (high performance liquid chromatography; HPLC), quantitative methods and pharmacodynamic evaluation model to analyze flavonoids HQT obtained from different sources. Ten batches were analyzed by HPLC 26 common peaks...
Valtrate is a principle compound isolated from Valeriana jatamansi Jones, which Traditional Chinese Medicine used to treat various mood disorders. The aim of the present study was investigate anxiolytic effects valtrate in rats. animals were orally administered (5, 10, and 20 g/kg daily) for 10 days exposed open field test (OFT) elevated plus‐maze (EPM). Then corticosterone levels rat serum measured by enzyme‐linked immunosorbent assay (ELISA). (10 mg/kg, p.o.) exhibited effect rats...
This work evaluated the effect of different cooking methods (boiling, steaming, microwaving, frying and pressure cooking) on nutrients, antioxidant activities, volatile nonvolatile taste-active components three varieties Lentinus edodes (808, 0912 LM) from Guizhou Province. The results showed that LM had most polysaccharides, minerals, but LM, 808 low amounts polyphenols, dietary fiber proteins, respectively. protein were decreased by 4.1~38.7% 4.1~44.0% during cooking, while microwaving...
Introduction This study was undertaken to explore the potential therapeutic effects of Tongyang Huoxue Granules (TYHX) on sinoatrial node (SAN) dysfunction, a cardiac disorder characterized by impaired impulse generation or conduction. The research question addressed whether TYHX could positively influence SAN ion channel function, specifically targeting sodium-calcium exchanger ( I NCX ) and L-type calcium CaL SAN. Methods Sinoatrial cells (SANCs) were isolated cultured from neonatal...