A5100408086- Sexual function and dysfunction studies
- Schizophrenia research and treatment
- Gut microbiota and health
- Migraine and Headache Studies
- Cancer, Stress, Anesthesia, and Immune Response
- Hormonal and reproductive studies
- Acupuncture Treatment Research Studies
- Urinary Bladder and Prostate Research
- Topic Modeling
- Bipolar Disorder and Treatment
- Mental Health and Psychiatry
- Psychosomatic Disorders and Their Treatments
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Sexuality, Behavior, and Technology
- Sepsis Diagnosis and Treatment
- Family Caregiving in Mental Illness
- Genital Health and Disease
- Probiotics and Fermented Foods
- Food composition and properties
- Machine Learning in Healthcare
- Natural Language Processing Techniques
- Brain Metastases and Treatment
- Healthcare and Venom Research
- Neurobiology of Language and Bilingualism
Florida Institute of Technology
2023-2024
The Alan Turing Institute
2021-2024
Shuguang Hospital
2021-2024
Shanghai University of Traditional Chinese Medicine
2021-2024
Massachusetts General Hospital
2022-2024
Third Affiliated Hospital of Sun Yat-sen University
2017-2022
Sun Yat-sen University
2017-2022
University of Oxford
2020-2021
Turing Institute
2021
Wuhan Third Hospital
2021
Context: Antipsychotic drugs are limited in their ability to improve the overall outcome of schizophrenia.Adding psychosocial treatment may produce greater improvement functional than does medication alone.Objective: To evaluate effectiveness antipsychotic alone vs combined with intervention on outcomes early-stage schizophrenia.Design: Randomized controlled trial.Setting: Ten clinical sites China.Participants: Clinical sample 1268 patients earlystage schizophrenia treated from January 1,...
Abstract Background Sepsis and trauma are known to disrupt gut bacterial microbiome communities, but the impacts perturbations in fungal (mycobiome) community after severe infection or injury, particularly patients experiencing chronic critical illness (CCI), remain unstudied. Methods We assess persistence of mycobiome perturbation (dysbiosis) CCI following sepsis for up two-to-three weeks intensive care unit hospitalization. Results show that dysbiotic arrays shift toward a pathobiome...
Recent work has suggested that disorganised speech might be a powerful predictor of later psychotic illness in clinical high risk subjects. To end, several automated measures to quantify disorganisation transcribed have been proposed. However, it remains unclear which are most strongly associated with psychosis, how different related each other and what the best strategies collect data from participants. Here, we assessed whether twelve Natural Language Processing markers could differentiate...
Introduction Cognitive decline is a common consequence of aging. Dietary patterns that lack fibers and are high in saturated fats worsen cognitive impairment by triggering pro-inflammatory pathways metabolic dysfunctions. Emerging evidence highlights the neurocognitive benefits fiber-rich diets crucial role gut-microbiome-brain signaling. However, mechanisms this diet-microbiome-brain regulation remain largely unclear. Methods Accordingly, we herein investigated unexplored neuroprotective...
Emerging evidence suggests that plant-based fiber-rich diets improve ageing-associated health by fostering a healthier gut microbiome and microbial metabolites. However, such effects mechanisms of resistant starches from dietary pulses remain underexplored. Herein, we examine the prebiotic pulses-derived starch (RS) on metabolome in older (60-week old) mice carrying human microbiome. Gut its association with are examined after 20-weeks feeding western-style diet (control; CTL) fortified (5%...
Introduction: Migraine is a recurrent neurological disorder, the symptoms of which can be significantly relieved by acupuncture. However, central mechanism via acupuncture exerts its therapeutic effect in migraine unclear. The aim this study was to compare differences regional homogeneity (ReHo) between patients with without aura (MwoA) and healthy controls (HCs) explore immediate cumulative MwoA using resting-state functional magnetic resonance imaging (fMRI). Methods: subjects were 40 16...
Perineural invasion has been found in several types of human tumors, and is associated with poor prognosis; however, few studies have examined perineural lung cancer. We evaluated the relationship between autonomic nervous densities, pathological risk grading, prognosis patients adenocarcinoma (LADC).Neural fiber expression was by immunofluorescence resected specimens control (n = 30), low-risk 22), high-risk LADC 43). The nerve densities normal tissue abnormal tissues tumor surrounding were...
Abstract Background Aging is one of the dominant factors contributing to erectile dysfunction (ED), and effective treatments for age-associated ED are urgently demanded. In this study, therapeutic efficiency bone marrow-derived mesenchymal stem cells (BMSCs) overexpressing microRNA-145 (miR-145) was evaluated in ED. Methods Sixty male Sprague-Dawley rats (24 months old) were randomly divided into 4 treatment groups ( n = 15/group): PBS (control), BMSCs, BMSCs transfected with a blank vector...
Abstract Early detection of sepsis is key to ensure timely clinical intervention. Since very few end-to-end pipelines are publicly available, fair comparisons between methodologies difficult if not impossible. Progress further limited by discrepancies in the reconstruction onset time. This retrospective cohort study highlights variation performance predictive models under three subtly different interpretations from sepsis-III definition and compares this against inter-model differences. The...
Emerging evidence reveals the fundamental role of gut microbiome in human health. Among various factors regulating our microbiome, diet is one most indispensable and prominent one. Inulin widely-studied dietary fiber for its beneficial prebiotic effects by positively modulating microbial metabolites. Recent research underscores sexual dimorphism sex-specific disparities also diet-microbiome interactions. However, whether how differ among sexes remain underexplored. To this end, we herein...
We explored the dynamic alterations of intrinsic brain activity and effective connectivity after acupuncture treatment to investigate underlying neurological mechanism in patients with migraine without aura (MwoA). The Functional Magnetic Resonance Imaging (fMRI) scans were separately obtained at baseline, first 12th sessions 40 MwoA. Compared healthy controls (HCs), MwoA mostly showed a decreased amplitude low-frequency fluctuation (dALFF) variability rostral ventromedial medulla (RVM),...
Abstract Dementia affects cognitive functions of adults, including memory, language, and behaviour. Standard diagnostic biomarkers such as MRI are costly, whilst neuropsychological tests suffer from sensitivity issues in detecting dementia onset. The analysis speech language has emerged a promising non-intrusive technology to diagnose monitor dementia. Currently, most work this direction ignores the multi-modal nature human communication interactive aspects everyday conversational...
Abstract Objective Early identification of bipolar disorder (BD) provides an important opportunity for timely intervention. In this study, we aimed to develop machine learning models using large-scale electronic health record (EHR) data including clinical notes predicting early-onset BD. Method Structured and unstructured were extracted from the longitudinal EHR Mass General Brigham system. We defined three cohorts aged 10 – 25 years: (1) full youth cohort (N=300,398); (2) a sub-cohort by...
This study was designed to evaluate the efficacy of psychosocial rehabilitation intervention on schizophrenia.One hundred forty schizophrenia outpatients in remission stage were randomized either an antipsychotic monomedication (control group) or plus a rehabitation training (trial group). Positive and Negative syndrome Scale (PANSS), Disability Screening Schedule (SDSS) performed longitudinally from baseline month 18 efficacy.Significant difference relapse rate between control group (42.9%)...
Psychological distress such as depression and anxiety resulted from coronavirus disease 2019 (COVID-19) have attracted increasing attention. The aim of this randomized controlled trial is to evaluate the effects safety auricular acupressure on in isolated COVID-19 patients.68 participants diagnosed with pneumonia (18-80 years old, SDS ≥ 50, SAS 45) were recruited randomly allocated group sham by a computer-generated random number sequence 9th June 30th 2022. allocation was only blinded...
Multiple measurements of nocturnal penile tumescence and rigidity (NPTR) are widely accepted as a method to differentiate psychogenic erectile dysfunction (ED) from organic ED. However, direct evidence remains limited regarding the first-night effect on NPTR measurement using RigiScan. Here, we evaluated results validate necessity for two consecutive nights, particularly when abnormal recorded in laboratory setting. We retrospectively reviewed 105 patients with complaint ED, who underwent...
Background: This randomized clinical trial (October 2012–December 2013) compared extracorporeal shock wave therapy (ESWT) and a vacuum erectile device (VED) for management of dysfunction (ED). Methods: Consecutive Chinese patients (20–55 years) with ED, abnormal nocturnal penile tumescence rigidity (NPTR), international index function-5 items (IIEF-5) score <22 were to receive ESWT or VED (twice weekly, 4 weeks). Primary outcomes treatment efficacy success rate weeks after completion...
Abstract We introduce the task of microblog opinion summarization (MOS) and share a dataset 3100 gold-standard summaries to facilitate research in this domain. The contains tweets spanning 2-year period covers more topics than any other public Twitter dataset. Summaries are abstractive nature have been created by journalists skilled summarizing news articles following template separating factual information (main story) from author opinions. Our method differs previous work on generating...
BackgroundAlterations in the static and dynamic characteristics of spontaneous brain activity have been extensively studied to investigate functional changes migraine without aura (MwoA). However, alterations concordance among dynamics MwoA remain largely unknown. This study aimed determine possibilities diagnosis based on indices.MethodsResting-state MRI scans were performed 32 patients with 33 matched healthy controls (HCs) first cohort, as well 36 HCs validation cohort. The indices...
Objective: To evaluate the persistence of intestinal microbiome dysbiosis and gut-plasma metabolomic perturbations following severe trauma or sepsis weeks after admission in patients experiencing chronic critical illness (CCI). Summary: Trauma can lead to gut alterations plasma fecal metabolome. However, impact these correlations between metabolome have not been studied. Methods: A prospective observational cohort study was performed with healthy subjects, patients, residing an intensive...
Abstract Recent work has suggested that disorganised speech might be a powerful predictor of later psychotic illness in clinical high risk subjects. To end, several automated measures to quantify disorganisation transcribed have been proposed. However, it remains unclear which are most predictive psychosis-onset, how different relate each other and what the best strategies elicit from participants. Here, we assessed ability twelve Natural Language Processing markers differentiate excerpts...