A5040764763- Gut microbiota and health
- Probiotics and Fermented Foods
- Diet and metabolism studies
- Food composition and properties
- Nutritional Studies and Diet
- Protein Hydrolysis and Bioactive Peptides
- Adipose Tissue and Metabolism
- Alzheimer's disease research and treatments
- Meat and Animal Product Quality
- Birth, Development, and Health
- Infant Nutrition and Health
- Tryptophan and brain disorders
- Nuts composition and effects
- Microbial Inactivation Methods
- Bee Products Chemical Analysis
- Diet, Metabolism, and Disease
- Biosensors and Analytical Detection
- Bacterial Identification and Susceptibility Testing
- Agricultural safety and regulations
- Salmonella and Campylobacter epidemiology
- Tea Polyphenols and Effects
- Identification and Quantification in Food
- Biochemical Analysis and Sensing Techniques
- Liver Disease Diagnosis and Treatment
- Microbial Metabolites in Food Biotechnology
Florida State University
2022-2025
National Dairy Research Institute
2020-2024
University of Delhi
2022
Alzheimer's disease (AD) is a debilitating brain disorder with rapidly mounting prevalence worldwide, yet no proven AD cure has been discovered. Using multi-omics approach in transgenic mouse model, the current study demonstrated efficacy of modified Mediterranean-ketogenic diet (MkD) on AD-related neurocognitive pathophysiology and underlying mechanisms related to gut-microbiome-brain axis. The findings revealed that MkD induces profound shifts gut microbiome community microbial...
Introduction Cognitive decline is a common consequence of aging. Dietary patterns that lack fibers and are high in saturated fats worsen cognitive impairment by triggering pro-inflammatory pathways metabolic dysfunctions. Emerging evidence highlights the neurocognitive benefits fiber-rich diets crucial role gut-microbiome-brain signaling. However, mechanisms this diet-microbiome-brain regulation remain largely unclear. Methods Accordingly, we herein investigated unexplored neuroprotective...
Dietary pulses, being a rich source of fiber and proteins, offer an ideal inexpensive food choice for older adults to promote gut metabolic health. However, the prebiotic effects dietary pulses-derived resistant starches (RS), compared RS from cereals tubers, remain relatively underexplored, particularly in context their modulatory potential old age. We herein investigate on microbiome intestinal health aged (60-week old) mice colonized with human microbiota. C57B6/J were fed 20 weeks either...
Emerging evidence suggests that plant-based fiber-rich diets improve ageing-associated health by fostering a healthier gut microbiome and microbial metabolites. However, such effects mechanisms of resistant starches from dietary pulses remain underexplored. Herein, we examine the prebiotic pulses-derived starch (RS) on metabolome in older (60-week old) mice carrying human microbiome. Gut its association with are examined after 20-weeks feeding western-style diet (control; CTL) fortified (5%...
The increase in concern from viable cells of probiotics specifically acute inflammatory conditions has led to the emergence concept postbiotics as a safer alternative therapy field health and wellness. aim present study was evaluate efficacy surface proteins three probiotic strains dextran sodium sulfate trinitrobenzenesulphonic acid = induced colitis mouse models. molecular weight total extracted ranged ∼25 ∼250 kDa with presence negligible levels endotoxins. Surface layer (SLPs) (∼45 kDa)...
Abstract Background Klebsiella pneumoniae is infamous for hospital-acquired infections and sepsis, which have also been linked to Alzheimer disease (AD)-related neuroinflammatory neurodegenerative impairment. However, its causative mechanistic role in AD pathology remains unstudied. Methods A preclinical model of K. enteric infection colonization developed an (3xTg-AD mice) investigate whether how pathogenesis exacerbates neuropathogenesis via the gut-blood-brain axis. Results pneumoniae,...
Abstract Background In previous studies, we found that an enteric infection caused by Klebsiella pneumoniae (Kpn) not only disturbs the balance of gut microbiome but also translocates to brain, leading inflammation and impairments in neurobehavior. Methods Triple-transgenic (3xTg-AD) mice were split into three categories: those infected with Kpn (Kpn group), a subset treated antibiotics induce dysbiosis (Kpn+Ab control group receiving no treatment (TgCt group). Metabolomic profiles gut,...
Western-style dietary patterns have been linked with obesity and associated metabolic disorders gut dysbiosis, whereas prudent snacking choices mitigate these predispositions. Using a multi-omics approach, we investigated how almond counters imbalances to adiposity an average American Diet (AAD). Fifteen adults overweight or underwent randomized, crossover-controlled feeding trial comparing 4-week AAD similar isocaloric diet supplemented 42.5 g/day of almonds (ALD). Almond increases...
Emerging evidence reveals the fundamental role of gut microbiome in human health. Among various factors regulating our microbiome, diet is one most indispensable and prominent one. Inulin widely-studied dietary fiber for its beneficial prebiotic effects by positively modulating microbial metabolites. Recent research underscores sexual dimorphism sex-specific disparities also diet-microbiome interactions. However, whether how differ among sexes remain underexplored. To this end, we herein...
Objectives: To examine the effect of a Mediterranean-ketogenic diet (MkD) versus Western-style (WD) on brain metabolome and transcriptomic profiles in transgenic murine model Alzheimer's disease. Methods: Wild-type (WT) double-transgenic (APP/PS1) mice (AD) (n=8-9/group) were fed either WD or MKD for 8-weeks. Brains harvested at end dietary intervention to measure metabolite receptors, pathologic markers (Amyloid-β tau proteins), inflammatory using Western blotting. Brain metabolomes...