A5035468491- Gut microbiota and health
- Diet and metabolism studies
- Gastrointestinal motility and disorders
- Animal Genetics and Reproduction
- Traditional Chinese Medicine Studies
- Dietary Effects on Health
- Spectroscopy and Chemometric Analyses
- Animal Ecology and Behavior Studies
- Genomics and Phylogenetic Studies
- Metabolomics and Mass Spectrometry Studies
- Physiological and biochemical adaptations
- Clostridium difficile and Clostridium perfringens research
Florida Institute of Technology
2024-2025
Aging-related abnormalities in gut microbiota are associated with cognitive decline, depression, and anxiety, but underlying mechanisms remain unstudied. Here, our study demonstrated that transplanting old to young mice induced inflammation the brain coupled anxiety. We observed diminished mucin formation increased permeability ("leaky gut") a reduction beneficial metabolites like butyrate because of decline butyrate-producing bacteria aged microbiota. This led suppressed expression...
Alzheimer's disease (AD) is a debilitating brain disorder with rapidly mounting prevalence worldwide, yet no proven AD cure has been discovered. Using multi-omics approach in transgenic mouse model, the current study demonstrated efficacy of modified Mediterranean-ketogenic diet (MkD) on AD-related neurocognitive pathophysiology and underlying mechanisms related to gut-microbiome-brain axis. The findings revealed that MkD induces profound shifts gut microbiome community microbial...
Clostridioides difficile (C. difficile) is a leading cause of hospital-associated diarrhea, primarily due to gut dysbiosis following antibiotic use. Probiotics have been found provide several benefits hosts via modulation the microbiota and their metabolites. However, till now, no conventional probiotics clearly proven be an effective prophylactic option for CDI prevention. Therefore, more studies on developing specific probiotic candidates targeting improving diversity administrated are...
Brevetoxins are a type of neurotoxin produced in red tide blooms. Northern quahogs (