A5100460731- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Cardiac Imaging and Diagnostics
- Advanced NMR Techniques and Applications
- Cardiovascular Function and Risk Factors
- Advanced Neuroimaging Techniques and Applications
- Ultrasound Imaging and Elastography
- Cardiac Valve Diseases and Treatments
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Neonatal and fetal brain pathology
- Quantum, superfluid, helium dynamics
- Advanced X-ray Imaging Techniques
- Ultrasound and Hyperthermia Applications
- Liver Disease Diagnosis and Treatment
- Superconducting Materials and Applications
- Functional Brain Connectivity Studies
- Gene Regulatory Network Analysis
- Advanced Electron Microscopy Techniques and Applications
- Medical Imaging and Pathology Studies
- Lanthanide and Transition Metal Complexes
- Language Development and Disorders
- Breast Lesions and Carcinomas
- Ultrasonics and Acoustic Wave Propagation
- Nonlinear Dynamics and Pattern Formation
Massachusetts General Hospital
2016-2024
Athinoula A. Martinos Center for Biomedical Imaging
2024
Chinese Academy of Sciences
2015-2023
Philips (United States)
2013-2023
University of Cincinnati Medical Center
2018-2023
Cincinnati Children's Hospital Medical Center
2014-2023
Institute of Electrical Engineering
2020-2023
Chongqing Medical University
2023
Xi'an Jiaotong University
2022
Xuzhou Medical College
2022
A major challenge in developmental biology is to understand the genetic and cellular processes/programs driving organ formation differentiation of diverse cell types that comprise embryo. While recent studies using single transcriptome analysis illustrate power measure heterogeneity complex biological systems, processing large amounts RNA-seq data from heterogeneous populations creates need for readily accessible tools single-cell (scRNA-seq) profiles. The present study presents a generally...
Although the breath-hold cine balanced steady state free precession (bSSFP) imaging is well established for assessment of biventricular volumes and function, shorter times or no breath-holds are beneficial in children severely ill sedated patients.
To further validate the ability of ultrashort echo-time (UTE) magnetic resonance imaging (MRI) in quantifying lung density patients diagnosed with chronic obstructive pulmonary disease (COPD) and to develop an MRI-based emphysema index (EI).Ten subjects clinically COPD (5M/5F, age 62.6 ± 8.5 years) ten healthy (2M/8F, 48.9 19.2 were imaged via UTE MRI at 3T (4 mm slices, 1.39 × mm2 pixels). Chest computed tomography (CT) images (generally 5 ≈0.55 0.55 pixels), acquired retrospectively,...
Purpose Magnetic resonance imaging of lungs is inherently challenging, but it has become more common with the use UTE sequences and their relative insensitivity to motion. Spiral have been touted recently as having greater k‐space sampling efficiencies than radial UTE, few are designed for shorter T 2 * lung. In this study, FLORET (Fermat looped, orthogonally encoded trajectories), a developed spiral 3D‐UTE sequence short species, was implemented in human first time images were compared...
Deep convolutional neural network (CNN) and its derivatives have recently shown great promise in the prediction of brain disorders using connectome data. Existing deep CNN methods single global row column filters limited ability to extract discriminative information from for tasks.This paper presents a novel Connectome-Inception (ConCeptCNN) model, which is developed based on multiple filters. The proposed model used topological features data neurological classification analysis.The...
129 Xe gas-transfer MRI provides regional measures of pulmonary gas exchange in adults and separates xenon interstitial lung tissue/plasma (barrier) from red blood cells (RBCs). The technique has yet to be demonstrated pediatric populations or conditions.To perform an exploratory analysis children.Prospective.Seventy-seven human volunteers (38 males, age = 17.7 ± 15.1 years, range 5-68 16 healthy). Four disease cohorts.3-T, three-dimensional-radial one-point Dixon Fast Field Echo (FFE)...
Purpose Hyperpolarized 129 Xe MRI characterizes regional lung ventilation in a variety of disease populations, with high sensitivity to airway obstruction early disease. However, images are usually limited single breath‐hold and most‐often acquired using gradient‐recalled echo sequences thick slices (~10‐15 mm), which increases partial‐volume effects, limits ability observe small defects, suffers from imperfect slice selection. We demonstrate higher‐resolution images, shorter breath‐holds,...
Purpose To enable efficient hyperpolarized 129 Xe diffusion imaging using 2D and 3D (Fermat Looped, ORthogonally Encoded Trajectories, FLORET) spiral sequences demonstrate that ADCs obtained these are comparable to those a conventional, gradient‐recalled echo (GRE) sequence. Theory Methods Diffusion‐weighted MRI ( b ‐values = 0, 7.5, 15 s/cm 2 ) was performed in four healthy volunteers one subject with lymphangioleiomyomatosis slice‐selective 2D‐GRE (scan time s), 2D‐Spiral (4 3D‐FLORET (16...
Breath-hold (BH) requirement remains the limiting factor on spatio-temporal resolution and coverage of cine balanced steady-state free precession (bSSFP) cardiovascular magnetic resonance (CMR) imaging. In this prospective two-center clinical trial, we validated performance a respiratory triggered (RT) bSSFP sequence for evaluation biventricular function. Our study included 23 asymptomatic healthy subjects 60 consecutive patients from Institute A (n = 39) B 21) referred clinically indicated...
Background Breath‐holding (BH) for cine balanced steady state free precession (bSSFP) imaging is challenging patients with impaired BH capacity. Deep learning‐based reconstruction (DLR) of undersampled k‐space promises to shorten BHs while preserving image quality and accuracy ventricular assessment. Purpose To perform a systematic evaluation DLR bSSFP images from over range acceleration factors. Study Type Retrospective. Subjects Fifteen pectus excavatum (mean age 16.8 ± 5.4 years, 20%...
We studied the impact of microstructural abnormalities in corpus callosum on language development 348 infants born very prematurely. discovered that fractional anisotropy anterior midbody was a significant predictor standardized scores at two years, independent clinical and social risk factors.
A project to develop a 9.4 T magnetic resonance imaging system is proposed for bioscience research applications. whole body superconducting magnet will be manufactured and test in the Institute of Electrical Engineering, Chinese Academy Sciences (IEE, CAS). This features room temperature bore 800 mm diameter, helium bath cooing, center field passive iron shielding. The designed with radial layer-winding method. Five coaxial coils wound independently assembled together as main magnet. Coil...
<h3>BACKGROUND AND PURPOSE:</h3> Spiral MR imaging has several advantages compared with Cartesian that can be leveraged for added clinical value. A multicenter multireader study was designed to compare spiral standard-of-care postcontrast structural brain on the basis of relative performance in 10 metrics image quality, artifact prevalence, and diagnostic benefit. <h3>MATERIALS METHODS:</h3> Seven sites acquired 88 total subjects. For each subject, 2 scans: a 2D T1 spin-echo, 1 4 routine...
Computational fluid dynamics (CFD) simulations of respiratory airflow have the potential to change clinical assessment regional airway function in health and disease, pulmonary medicine otolaryngology. For example, diseases where multiple sites obstruction occur, such as obstructive sleep apnea (OSA), CFD can identify which contribute most resistance may therefore be candidate for surgery. The main barrier uptake date has been difficulty validating results against a gold standard. Invasive...
Magnetic field shimming of the magnet is a routine practice in magnetic resonance imaging (MRI) system. For clinically-used 1.5 T or 3 MRI superconducting magnets, it generally straightforward to achieve desired uniformity with passive shim technique. In comparison, shims higher efficiency are usually introduced combination satisfy requirement for ultrahigh magnets (≥7 Tesla). However, involves complex winding structure and low-temperature environment, bringing considerable engineering...
Infants born very preterm (VPT) are at risk of later visual problems. Although neonatal screening can identify ophthalmologic abnormalities, subtle perinatal brain injury and/or delayed maturation may be significant contributors to complex visual-behavioral Our aim was assess the micro and macrostructural antecedents early difficulties in VPT infants by using diffusion MRI (dMRI) term-equivalent age. We prospectively recruited a cohort 262 (≤32 weeks gestational age [GA]) from five intensive...
Cardiac motion analysis can play an important role in cardiac disease diagnosis. Tagged magnetic resonance imaging (MRI) has the ability to directly and non-invasively alter tissue magnetization produce tags on deforming tissue. This paper proposes approach of tagged MR images using a multilevel B-splines fitting model incorporating phase information. The novelty proposed technique is that information extracted from SinMod.<sup>1</sup> By real tag intersections image data virtual...
Rationale Hyperpolarized (HP) 129 Xe‐MRI provides non‐invasive methods to quantify lung function and structure, with the Xe apparent diffusion coefficient (ADC) being a well validated measure of alveolar airspace size. However, experimental factors that impact precision accuracy HP ADC measurements have not been rigorously investigated. Here, we introduce an analytical model predict uncertainty estimates. Additionally, report dependence on age in healthy pediatric volunteers. Methods An...
Phase-contrast (PC) MRI is a non-invasive technique to assess cardiovascular blood flow. However, this not accurate for instance at the carotid bifurcation due turbulent and disturbed flow in atherosclerotic disease. Flow quantification using conventional PC distal stenotic vessels suffers from intravoxel dephasing artifacts. Previous studies have shown that short echo time (TE) potentially decreases phase errors. In work, novel 3D cine UTE-PC imaging method designed measure velocity UTE...
In this paper, we propose a novel 3D sine wave modeling (3D SinMod) approach to automatic analysis of cardiac deformations. An accelerated complementary spatial modulation magnetization (CSPAMM) tagging technique was used modulate the myocardial tissue and acquire MR data sets whole-heart including three orthog- onal tags within breath-holds. Each tag set is able assess motion along direction perpendicular lines. With application CSPAMM, effect fading encountered in SPAMM due T1 relaxation...