A5019041160- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Osteoarthritis Treatment and Mechanisms
- Hip and Femur Fractures
- Hip disorders and treatments
- Bone and Joint Diseases
- Orthopedic Infections and Treatments
- Bone Metabolism and Diseases
- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- MicroRNA in disease regulation
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Pelvic and Acetabular Injuries
- Shoulder Injury and Treatment
- Sports injuries and prevention
- Bone health and osteoporosis research
- Chemokine receptors and signaling
- Shoulder and Clavicle Injuries
- Telomeres, Telomerase, and Senescence
- Extracellular vesicles in disease
- Polymer Surface Interaction Studies
- Medicinal Plant Pharmacodynamics Research
Pudong Medical Center
2021-2025
Fudan University
2021-2025
Shanghai First People's Hospital
2009-2021
Shanghai Jiao Tong University
2011-2021
Huazhong University of Science and Technology
2001-2004
Excess osteoclast activity is found in many bone metabolic diseases, and inhibiting differentiation has proven to be an effective strategy. Here, we revealed that precursors (pre-OCs) were more susceptible thioredoxin reductase 1 (TXNRD1) inhibitors than marrow-derived monocytes (BMDMs) during receptor activator of nuclear factor kappa B ligand (RANKL)-mediated osteoclastogenesis. Mechanistically, activated T-cells (NFATc1) upregulated solute carrier family 7 member 11 (SLC7A11) expression...
A composite scaffold was fabricated with a method involving both electrospinning and 3D printing to give microscale pores good mechanical properties. Biocompatibility cell infiltration on the evaluated by an<italic>in vitro</italic>study.
MiR-140 is a microRNA specially involved in chondrogenesis and osteoarthritis pathogenesis. However, its transcriptional regulation target genes cartilage development are not fully understood. Here we detected that miR-140 was uniquely expressed chondrocyte suppressed by Wnt/β-catenin signalling. The primary transcript an intron-retained RNA co-expressed with Wwp2-C isoform, which directly induced Sox9 through binding to the intron 10 of Wwp2 gene. Knockdown limb bud micromass cultures...
Abstract Signal transducer and activator of transcription 3 (STAT3) has important roles in cancer aggressiveness been confirmed as an attractive target for therapy. In this study, we used a dual-luciferase assay to identify that pectolinarigenin inhibited STAT3 activity. Further studies showed constitutive interleukin-6-induced signaling, diminished the accumulation nucleus blocked DNA-binding activity osteosarcoma cells. Mechanism investigations indicated disturbed STAT3/DNA...
Repair and reconstruction of critical-sized bone defects has always been a difficult task in orthopedics. Hypoxia inducible factor-1α (HIF-1α) plays an important role defect repair, it the dual function promoting osteogenesis vascular regeneration, but is quickly degraded by body under normoxic conditions. Previously we prepared mutant HIF-1α, which shown to efficiently maintain cellular expression In this study, evaluated for first time exosomes rat marrow mesenchymal stem cell carry HIF-1α...
Abstract Molecular recognition at the biointerface plays a critical role in sensing molecular interactions (e.g., DNA hybridization) and extracellular changes, which can directly affect detection performance of biosensors sensitivity, specificity, response dynamics). However, conventional biointerfaces show low efficiency due to limited target accessibility. Engineering regulate orientation, spacing, density surface‐confined probes offer an effective approach improve interfaces. Over last...
Objectives This study aimed to investigate the relationship between albumin-corrected anion gap (ACAG) and lumbar spine bone mineral density (BMD) in a diverse population, assessing how variations ACAG levels correlate with changes BMD potential implications for osteoporosis risk. Methods A cross-sectional analysis was conducted involving 3,057 participants (1,555 males 1,502 females). Participants were stratified into quartiles based on baseline levels. Demographic clinical characteristics...
Reducing oxidative stress (ROS) have been demonstrated effective for steroid-induced osteonecrosis of the femoral head (steroid-induced ONFH). Selenium (Se) plays an important role in suppressing and has huge potential ONFH treatments. However Se a narrow margin between beneficial toxic effects which make it hard therapy use vivo. In order to deficiency up, control release (Se@SiO2) were realized by nanotechnology modification. Porous Se@SiO2 nanocomposites favorable biocompatibility can...
Achilles tendon rupture prognosis is usually unsatisfactory. After the injured, it may not function properly because of fibrotic healing response, which restrains motion. Inflammatory monocytes and tissue-resident macrophages are indispensable regulators in tissue repair, fibrosis, regeneration. Exosomes from crucial factors microenvironment regulation following injury. This study therefore aimed to clarify roles macrophage exosomes injury (TI) repair. The results show that play a role after...
Fractures of different parts the proximal humerus may lead to postoperative functional deficits, but there are few studies on morphology and related functions humerus. The purpose this study was analyze fracture pattern by three-dimensional (3-D) mapping technique further evaluate its clinical utility.Patients with humeral fractures admitted Pudong Hospital, Fudan University, from January 2018 December 2020, were analyzed. Three surgeons divided into groups according 3-D CT imaging mapped a...
Abstract Background The characteristics and therapeutic potential of subtypes bone marrow mesenchymal stem cells (BMSCs) are largely unknown. Also, the application subpopulations BMSCs in cartilage regeneration remains poorly characterized. aim this study was to explore regenerative capacity CD146-positive for repairing defects. Methods (CD146 + BMSCs) were sorted by self-developed CD146-specific lipid magnetic spheres (CD146-LMS). Cell surface markers, viability, proliferation evaluated...
ABSTRACT Recent evidence indicates that the damaged regions in osteoarthritis are accompanied by accumulation of iron ions. Ferroptosis, as an iron‐dependent form cell death, holds significant implications osteoarthritis. Melatonin, a natural product with strong scavenging abilities against reactive oxygen species and lipid peroxidation, plays crucial role treatment This study aims to demonstrate existence ferroptosis explore specific mechanism melatonin suppressing alleviating Our findings...
Abstract There are many in vitro experiments showing that particulate bioactive glasses have a broad and certain antibacterial effect, but there is no report about this effect vivo so far. The aim of study to examine the efficacy Bioglass® reducing rate infection with Staphylococcus aureus after fixation open tibial fractures rabbits. test was carried out male rabbits split into two groups infected at right fracture sites fixed plate screw, either or without glass respectively. Culture...
Background/objectives: Polyethylene terephthalate (PET)-based artificial ligaments are one of the most commonly used grafts in anterior cruciate ligament (ACL) reconstruction surgery. However, lack favorable hydrophilicity and cell attachment for PET highly impeded its widespread application clinical practice. Studies found that surface modification on materials could enhance biocompatibility bioactivity ligaments. In this study, we immobilized bone morphogenetic protein-2 (BMP-2) mediated...
Previous studies have demonstrated that long non-coding RNA maternally expressed gene 3 (MEG3) emerged as a key regulator in development and tumorigenesis. This study aims to investigate the function mechanism of MEG3 osteogenic differentiation bone marrow mesenchymal stem cells (BMSCs) explores use skull defects repairing.Endogenous expression during BMSCs was detected by quantitative real-time polymerase chain reaction (qPCR). knockdown lentiviral transduction. The proliferation,...
Postmenopausal osteoporosis (PMOP) is a kind of primary that characterized by decreased bone density and strength. Berbamine nonbasic quaternary benzylisoquinoline plant alkaloid has been widely used in the clinic to treat leukopenia China. We found berbamine inhibited RANKL-induced osteoclastogenesis marrow-derived macrophages (BMMs) vitro , which mainly occurred middle phase late phase. The gene protein expression levels osteoclast-related molecules, including CTSK, MMP-9, NFATc1, CD44...