Jaikirshan Khatri
A5030769266- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Vascular Procedures and Complications
- Cerebrovascular and Carotid Artery Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Coronary Artery Anomalies
- Mechanical Circulatory Support Devices
- Kawasaki Disease and Coronary Complications
- Cardiac Arrhythmias and Treatments
- Radiation Dose and Imaging
- Venous Thromboembolism Diagnosis and Management
- Innovation Policy and R&D
- Cardiovascular Issues in Pregnancy
- Aortic Disease and Treatment Approaches
- Health Systems, Economic Evaluations, Quality of Life
- Pain Management and Treatment
- COVID-19 and healthcare impacts
- Advanced Machining and Optimization Techniques
- COVID-19 Clinical Research Studies
Cleveland Clinic
2017-2025
Cornell University
2025
George Mason University
2025
Edwards Comprehensive Cancer Center
2024
Marshall University
2024
Minneapolis Heart Institute Foundation
2019-2024
Abbott Northwestern Hospital
2019-2024
Allina Health
2024
Australian Government
2023
Services Australia
2023
Vascular remodeling, defined as any enduring change in the size and/or composition of an adult blood vessel, allows adaptation and repair. On other hand, inappropriate including its absence, underlies pathogenesis major cardiovascular diseases, such atherosclerosis restenosis. Since degradation extracellular matrix scaffold enables reshaping tissue, participation specialized enzymes called metalloproteinases (MMPs) has become object intense recent interest relation to physiological (“good”)...
Background— Although multiple pathological processes have been associated with oxidative stress, the causative relation between stress and arterial lesion progression remains unclear. Methods Results— To test effect of creating wall we compared mouse carotid lesions induced by flow cessation in wild-type (WT) versus transgenic mice (Tg p22vsmc ), which overexpression p22phox, a critical component NAD(P)H oxidase was targeted to smooth muscle cell (SMC). Compared WT mice, grew significantly...
Coronary artery perforation is a feared complication of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) and often leads to serious adverse clinical events.
<i>In vitro</i> experiments showing the activation of myosin phosphatase via heterophilic leucine zipper interactions between its targeting subunit (MYPT1) and cGMP-dependent protein kinase I suggested a pathway for smooth muscle relaxation (Surks, H. K., Mochizuki, N., Kasai, Y., Georgescu, S. P., Tang, K. M., Ito, Lincoln, T. Mendelsohn, M. E. (1999) <i>Science</i> 286, 1583–1587). The relationship MYPT1 isoform expression responses to cGMP signaling <i>in vivo</i> has not been explored....
Background — Recent observations associate plaque instability with expansive arterial remodeling, suggesting a common driving mechanism. Methods and Results To demonstrate that macrophages, characteristic of vulnerable plaques, also assist in we compared carotid artery remodeling due to formation experimental macrophage-rich macrophage-poor lesions the flow cessation model hypercholesterolemic apolipoprotein E knockout (ApoE KO) wild type (WT) mice. After ligation, macrophages started...
The use of the Ostial Flash balloon (Ostial Corporation) has received limited study in aorto-ostial chronic total occlusion (CTO) percutaneous coronary artery intervention (PCI). authors evaluated outcomes a large CTO-PCI registry (PROGRESS-CTO, NCT02061436). was used 54 907 CTO PCIs 905 patients (6.0%). mean patient age 65.1 ± 10.7 and 80.6% were men, with high prevalence diabetes mellitus, hypertension, prior PCI, myocardial infarction. length 40.5 25.1 mm, 52.2% had moderate to severe...
We present a clinical case highlighting high-definition intravascular ultrasound (HD-IVUS)-guided tip detection-antegrade dissection and re-entry (ADR). This novel technique in percutaneous coronary intervention of chronic total occlusions was pioneered Japan using specially designed catheter (AnteOwl WR IVUS, Terumo) replicated this off-the-shelf equipment after antegrade retrograde attempts with conventional methods were unsuccessful. To the best our knowledge, marks first successful...
Chest tubes are widely used for the management of primary spontaneous pneumothorax. The most common complication chest tube is a nonfunctioning tube, which might lead to recurrent pneumothorax during hospital admission. We describe case 13-year-old tall and thin-built African American male who presented emergency department (ED) with large right-sided diagnosed X-ray (CXR). Pneumothorax was managed three-compartment drainage system. Serial CXR revealed improvement in after insertion. patient...
ABSTRACT Background Vascular access‐site complications (VASC) can occur during chronic total occlusion (CTO) percutaneous coronary intervention (PCI). Methods We compared the baseline and procedural characteristics, outcomes of patients with versus without VASC in a large multicenter CTO PCI registry. was defined as any following: small hematoma (hematoma < 5 cm), ≥ arteriovenous fistula, pseudoaneurysm acute arterial closure. Results occurred 158 16,810 PCIs (0.9%). were older (67 ± 11...
The impact of contrast type in chronic total occlusion (CTO) percutaneous coronary intervention (PCI) remains controversial. authors sought to evaluate the medium selection on patients undergoing CTO PCI. examined outcomes who underwent PCI using iso-osmolar (iodixanol) vs pooled low-osmolar media (LOCM) data from PROGRESS-CTO registry. Iodixanol was used 1007 (18.1%) 5558 PCIs. Compared with LOCM, iodixanol-treated were more likely be women, older, and have diabetes, dyslipidemia,...
The outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in patients with obstructive sleep apnea syndrome (OSAS) have received limited study. We compared the procedural characteristics and CTO PCIs without OSAS a multicenter registry. Of 7,403 who underwent 7,408 between 2012 2024 at 47 centers, 942 (13%) had OSAS. Compared OSAS, were older; more likely to be men; higher prevalence diabetes, hypertension, dyslipidemia, cerebrovascular disease, previous heart...