A5100446219- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Coronary Artery Anomalies
- Kawasaki Disease and Coronary Complications
- Acute Myocardial Infarction Research
- Gastric Cancer Management and Outcomes
- Organ Transplantation Techniques and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Esophageal and GI Pathology
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Structural Anomalies and Repair
- Artificial Intelligence in Healthcare and Education
- Renal Transplantation Outcomes and Treatments
- Medical Imaging and Analysis
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- Heart Rate Variability and Autonomic Control
- Cardiac Arrest and Resuscitation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Esophageal Cancer Research and Treatment
- HIV Research and Treatment
- AI in cancer detection
- Retinal Imaging and Analysis
- Advanced Radiotherapy Techniques
National Institutes for Food and Drug Control
2018-2025
Obstetrics and Gynecology Hospital of Fudan University
2025
University of California, San Diego
2023-2024
Rady Children's Hospital-San Diego
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2024
Meizhou City People's Hospital
2024
Northwestern Polytechnical University
2024
State Key Laboratory of Cardiovascular Disease
2022-2023
Renmin Hospital of Wuhan University
2020-2023
Shenzhen Second People's Hospital
2023
Integration is essential for HIV-1 replication, and the viral integrase (IN) protein an important therapeutic target. Allosteric IN inhibitors (ALLINIs) that engage dimer interface at binding site host lens epithelium-derived growth factor (LEDGF)/transcriptional coactivator p75 are emerging class of small molecule antagonists. Consistent with inhibition a multivalent drug target, ALLINIs display steep antiviral dose–response curves ex vivo. multimerize concordantly block its assembly DNA in...
The binding of integrase (IN) to lens epithelium-derived growth factor (LEDGF)/p75 in large part determines the efficiency and specificity HIV-1 integration. However, a significant residual preference for integration into active genes persists Psip1 (the gene that encodes LEDGF/p75) knockout (KO) cells. One other cellular protein, HRP2, harbors both PWWP IN-binding domains are important LEDGF/p75 co-factor function. To assess role HRP2 integration, cells generated from Hdgfrp2 HRP2)...
Owing to its superior resolution, intravascular optical coherence tomography (IVOCT) is a promising tool for imaging the microstructure of coronary artery walls. However, IVOCT does not identify chemicals and molecules in tissue, which required more complete understanding accurate diagnosis disease. Here we present dual-modality system catheter that uniquely combines with diffuse near-infrared spectroscopy (NIRS) single device simultaneous acquisition microstructural compositional...
Although Kawasaki disease is commonly regarded as a single entity, variability in clinical manifestations and outcome has been recognised. We aimed to use data-driven approach identify subgroups.We analysed data from patients with diagnosed at Rady Children's Hospital (San Diego, CA, USA) between Jan 1, 2002, June 30, 2022. Patients were grouped by hierarchical clustering on principal components k-means parcellation based 14 variables, including age onset, ten laboratory test results, day of...
Abstract Objective Dyslipidemia is a co-existing problem in patients with diabetes mellitus (DM) and coronary artery disease (CAD), apolipoprotein E (APOE) plays an important role lipid metabolism. However, the relationship between APOE gene polymorphisms risk of developing CAD type 2 DM (T2DM) remains controversial. The aim this study was to assess provide reference for further assessment T2DM patients. Methods included 378 complicated (T2DM + CAD) 431 alone case group, 351 individuals...
Endobronchial ultrasound (EBUS) is now widely used in patients with resectable non-small-cell lung cancer to sample mediastinal lymph nodes (LN) for preoperative staging. The aim of this study was investigate prospectively the utility six criteria predict malignancy LN.EBUS performed lymphadenopathy irrespective underlying disease. following were expected malignancy: short axis >1 cm, heterogeneous pattern, round shape, distinct margin, absence a central hilar structure and high blood flow...
Preeclampsia (PE) is a prevalent and severe pregnancy complication that significantly impacts maternal perinatal health. Epidemiological studies animal experiments have demonstrated PE adversely affects the cardiovascular nervous systems of offspring, increasing their risk hypertension renal pathology. However, mechanisms underlying this increased remain unclear. This study utilized an L-NAME-induced preeclampsia mouse model (PELS model) to investigate effects on offspring blood pressure...
While optical coherence tomography (OCT) has been shown to be capable of imaging coronary plaque microstructure, additional chemical/molecular information may needed in order determine which lesions are at risk causing an acute event.In this study, we used a recently developed system and double-clad fiber (DCF) catheter simultaneously acquiring both OCT red excited nearinfrared autofluorescence (NIRAF) images (excitation: 633 nm, emission: 680nm 900nm).We found that NIRAF is elevated contain...
Diabetes is a significant risk factor for peripheral arterial disease (PAD) and associated with accelerated atherosclerosis limb loss. However, the pathophysiology involved in PAD unclear. This study was conducted to evaluate hemodynamic response exercise of patients without diabetes PAD.The calf muscles diabetes, PAD, or both determined using near-infrared spectroscopy (NIRS). Patients performed plantar-flexion treadmill-walking regimen.Skeletal muscle capillary blood volume expansion...
Abstract We examined whether men with restless legs syndrome (RLS) have a higher prevalence of Parkinson's disease (PD) among 23,119 US participants the Health Professional Follow‐up Study who were free diabetes and arthritis. RLS was assessed using set standardized questions recommended by International Group. PD cases identified self‐reported questionnaires confirmed review medical records. Compared to without RLS, multivariate‐adjusted odds ratios for 1.1 (95% confidence interval: 0.4,...
Study Objectives:Dopaminergic hypofunction in the central nervous system may contribute to restless legs syndrome (RLS) and erectile dysfunction (ED). We therefore examined whether men with RLS have higher prevalences of ED.
Objective: In the last two decades, incidence of ventricular fibrillation has significantly decreased as presenting rhythm in sudden cardiac arrest. We hypothesized that beta-adrenergic receptor blocker (β-blocker) and angiotensin converting enzyme inhibitor, which were commonly used primary secondary prevention strategies recommended by American Heart Association during same decrease duration after onset Design: Randomized prospective animal study. Setting: University affiliated research...
The lymphatic vasculature has been shown to play important roles in lung injury and repair, particularly fibrosis. effects of ionizing radiation on have not previously reported.C57Bl/6 mice were immobilized a lead shield exposing only the thoracic cavity, irradiated with single dose 14 Gy. Animals sacrificed lungs collected at different time points (1, 4, 8, 16 weeks) following radiation. To identify vessels tissue sections, we used antibodies that are specific for vessel endothelial...
The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays major role in various pathological conditions the central nervous system (CNS), implicated several neuropsychiatric disorders. Imaging of brain using positron emission tomography (PET) could serve as noninvasively tool for enhancing understanding disease's pathophysiology. Moreover, PET tracers can be used target validation and quantification diagnosis. Herein, we describe radiosynthesis, vivo PET/CT imaging novel...
Purpose: To compare the efficacy and safety of CT-guided 125I seed implantation with second-line chemotherapy in treatment oligorecurrence NSCLC after failure first-line chemotherapy. Materials Methods: Data patients at two institutions were retrospectively reviewed from January 2013 to July 2018. A total 53 who received eligible for this study. In Group A, 25 permanent implantation, while B, 28 The outcomes measured terms disease control rate, overall survival, quality life, complications....
Jailed balloon technique (JBT) is an active side branch (SB) protection strategy and considered to be superior the jailed wire (JWT) in reducing SB occlusion. However, no randomized trials have proved that. We aim investigate whether JBT could decrease occlusion rate.Conventional versus Intentional straTegy patients with high Risk prEdiction of Side OccLusion coronary bifurcation interVEntion (CIT-RESOLVE) (NCT02644434, registered on December 31, 2015) (https://clinicaltrials.gov) a trial...
In ST-segment elevation myocardial infarction (STEMI) with the restoration of TIMI 3 flow by percutaneous coronary intervention (PCI), visually defined microvascular obstruction (MVO) was shown to be predictor poor prognosis, but not an ideal risk stratification method. We intend introduce deep neural network (DNN) assisted contrast echocardiography (MCE) quantitative analysis and propose a better model.194 STEMI patients successful primary PCI at least 6 months follow-up were included. MCE...
Aims: The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. aim this study was evaluate the effectiveness isolated coronary artery bypass combined with bone marrow mononuclear (BMMNC) delivered through vessels improve left ventricular remodeling patients previous myocardial infarc- tion and chronic heart failure using echocardiography. Material methods: Patients infarction were randomly allocated one two groups: CABG only (18 patients), or BMMNC...
Objectives The graft of stem cells to treat ischemic cardiomyopathy is popular in many clinical trials. aim this study was evaluate the effectiveness isolated coronary artery bypass combined with bone marrow mononuclear (BMMNC) delivered through vessels improve left ventricular function patients previous myocardial infarction and chronic heart failure using echocardiography. Methods Forty‐two were randomly allocated one two groups: CABG only (18 group), or BMMNC transplantation (24 + group)....