A5077877675- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Liver physiology and pathology
- Advanced MRI Techniques and Applications
- Parasites and Host Interactions
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Toxoplasma gondii Research Studies
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Reproductive System and Pregnancy
- Ultrasound and Hyperthermia Applications
- Cardiomyopathy and Myosin Studies
- Pulmonary Hypertension Research and Treatments
- Trace Elements in Health
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Coronary Interventions and Diagnostics
- Tissue Engineering and Regenerative Medicine
- Tuberculosis Research and Epidemiology
- Infective Endocarditis Diagnosis and Management
- Macrophage Migration Inhibitory Factor
- Liver Disease and Transplantation
- Electrospun Nanofibers in Biomedical Applications
- Cytomegalovirus and herpesvirus research
Second Affiliated Hospital of Nanchang University
2024-2025
Nanchang University
2024-2025
Tianjin University
2024
Renmin Hospital of Wuhan University
2015-2024
Wuhan University
2015-2024
Nantong University
2015-2024
People's Hospital of Yangzhong
2024
First Affiliated Hospital of Shantou University Medical College
2024
Shantou University
2024
Bozhou People's Hospital
2024
Precise mapping and regulation of cell surface receptors hold immense significance in disease treatment, such as cancer, infection, neurodisorders, but also face enormous challenges. In this study, we designed a series adjustable multivalent aptamer-based DNA nanostructures to precisely control their interaction with tumor cells. By profiling on 12 lines using 10 different aptamers, generated heatmap that accurately distinguished between various types based multiple markers. We then...
Zika virus (ZIKV) infection during pregnancy in humans results intrauterine growth restriction, spontaneous abortion, and microcephaly. Here, we found that fetus-derived type I interferon (IFN-I) signaling can enhance anti-ZIKV responses provide clinical benefits to the fetus. Because IFN-λ shares cascades antiviral functions with IFN-I, investigated vivo effects of ZIKV-infected pregnant mice. administration mid-pregnancy reduced ZIKV burden maternal fetal organs alleviated placental...
ABSTRACT Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, is zoonotic pathogen that prevalent in some Southeast Asian countries and causes acute humans. To evaluate the potential application of gene immunization to JEV infection, we characterized immune responses from mice intramuscularly injected with plasmid DNA encoding glycoproteins, including precursor membrane (prM) plus envelope (E) proteins nonstructural protein NS1. When expressing prM E, 70% immunized survived after...
In the process of hepatic fibrosis, stellate cells (HSCs) can be activated by many inflammatory cytokines. The transforming growth factor-β1 (TGF-β1) is one main profibrogenic mediators. Recently, some studies have also shown that microRNAs (miRNAs) play essential roles in progress liver fibrosis being involved differentiation, fat metabolism and ECM production HSCs. expression miR-454 LX-2 treated with TGF-β1 fibrotic livers Schistosoma japonicum infection was detected qRT-PCR. role on then...
Cardiac dysfunction in diabetic cardiomyopathy may be associated with abnormal Ca2+ homeostasis. This study investigated the effects of alterations homeostasis and sarcoplasmic reticulum Ca2+-associated proteins on cardiac function development cardiomyopathy. Sprague–Dawley rats were divided into 4 groups (n = 12, each): a control group, streptozotocin-induced rat models diabetes groups, examined after 4, 8, or 12 weeks. Evaluations structure performed by echocardiography hemodynamic...
Abstract Schistosomiasis is a tropical parasitic disease that damages the liver and poses serious threat to human health. Macrophages play key role in development of granulomas fibrosis by undergoing polarization from M1 M2 type during schistosomiasis. Therefore, regulating macrophage important for controlling pathological changes occur this disease. Triggering receptor expressed on myeloid cells 2 (TREM2) surface macrophages, dendritic other immune has been shown inhibiting inflammatory...
Background The induction of hepatic stellate cell (HSC) apoptosis has potential as a potent strategy to diminish the progression liver fibrosis. Previous studies have demonstrated ability soluble egg antigens (SEA) from schistosomes inhibit HSC activation and induce in vitro. In this study, we aimed explore mechanism SEA-induced HSCs. Methodology/Principal Findings found that SEA could upregulate p53 DR5 downregulate p-Akt. HSCs induced by be reduced were treated with p53-specific siRNA...
Abstract Liver fibrosis is a serious disease that characterized by the excess deposition of extracellular matrix (ECM) components. Activated hepatic stellate cells (HSCs) are major source ECM and serve as key regulator in liver fibrogenesis. Inactivation HSCs essential for fibrotic regression. The present study explores underlying mechanisms Schistosoma japonicum egg antigen p40 (Sjp40) promoting senescence antifibrosis. For first time we report Sjp40 inhibits activation proliferation an...
Abstract The recent outbreaks of Zika virus (ZIKV) in multiple countries are linked to increased risk neurological disorders and congenital defects. However, host immunity immune-mediated pathogenesis ZIKV infection not well understood. Interleukin-22 (IL-22) is a crucial cytokine for regulating infectious diseases. Whether IL-22 plays role entirely unknown. Here, we infected 3-week-old Ifnar1−/− mice with (Cambodian isolate, 1.0×105 pfu/mouse), found that resulted weight loss, paralysis,...
In this study, a strain of
Abstract Liver fibrosis is characterized by the activation of hepatic stellate cells (HSCs). Recent findings suggest that senescence activated HSCs might limit development liver fibrosis. Based on previously observed anti-fibrotic effects soluble egg antigens from Schistosoma japonicum in vitro, we hypothesized SEA play a crucial role alleviating through promoting HSCs. We show here inhibited expression α-SMA and pro-collagen I promoted vitro . In addition, induced an increased P-p53 p21....
Lactic acid fermentation is a promising method for developing sandwich seaweed scraps. The objectives of this study were to investigate the effect with Lactiplantibacillus plantarum MMB-05, casei FJAT-7928, mixed bacteria (1:1, v/v) and control on physicochemical indexes, in vitro antioxidant activity, volatile compounds Porphyra yezoensis sauce. Sensory evaluation was also performed. results indicated that all lactic strains grew well P. sauce after 72 h fermentation, viable cell counts L....
This study is aimed to explore the feasibility of ultrasound on enhancing fermentation properties ginkgo kernel juice by Lactiplantibacillus plantarum Y2. Specifically, at 20 kHz and different intensities (mild intensity-84.42 W/L, moderate intensity-115.50 high intensity-173.88 W/L) with a pulse mode were applied facilitate process. The number viable cells Y2 increased 5.06, 5.05 2.19% in sonicated groups 173.88, 115.50 84.42 compared non-sonicated after 24-h fermentation. Furthermore, mild...
Abstract Background Toxoplasma gondii , an obligate intracellular parasitic protozoa, infects approximately 30% of the global population. Contracting T. at primary infection mother can result in neonatal microcephaly, chorioretinitis, hydrocephalus, or mortality. Our previous study indicated that pregnant mice infected with displayed a decrease both number and suppressive ability regulatory T cells, accompanied by reduced Forkhead box P3 (Foxp3). Numerous studies have proved microRNAs...
Post-stroke depression (PSD) is a prevalent psychiatric complication in stroke patients, severely reducing quality of life and delaying social recovery survivors. Clinical studies have shown that acupuncture can be used as an alternative approach for PSD. The aim this study was to examine the safety, efficacy, electroencephalogram (EEG) mechanism treating PSD patients. From October 28, 2022 May 16, 2023, single-center, single-blind, randomized clinical trial conducted at Second Affiliated...
Toxoplasma gondii is an opportunistic intracellular parasite that highly prevalent in human and warm-blooded animals throughout the world, leading to potentially severe congenital infections. Although abortion caused by T. believed be dependent on timing of maternal infection during pregnancy, mechanism remains unclear. This study was focused effects excreted-secreted antigens pregnant outcomes CD4+CD25+ Foxp3+ regulatory T cells at different stages pregnancy. The results showed mice...
As an indispensable enzyme for the hydrolysis of dextran, dextranase has been widely used in fields food and medicine. It should be noted that weak thermostability become a restricted factor industrial applications. This study aims to improve AoDex glycoside hydrolase (GH) family 49 derived from Arthrobacter oxydans KQ11. Some mutants were predicted constructed based on B-factor analysis, PoPMuSiC HotMuSiC algorithms, four exhibited higher heat resistance. Compared with wild-type, mutant...
Abstract A number of studies have shown that the transplantation bone marrow‐derived mesenchymal stem cells (BMSCs) into thinned infarct wall improves regional motion. In this study, we hypothesized injection biomaterials and MSCs infarcted myocardium can preserve left ventricular (LV) function. To test hypothesis, anterior acute myocardial infarction (AMI) was induced in 34 rabbits BMSCs with hydrogel composite were prepared. One week after inducing AMI, 28 divided four groups (Groups A–D;...