A5026182826- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Epigenetics and DNA Methylation
- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cholinesterase and Neurodegenerative Diseases
- Stroke Rehabilitation and Recovery
- Circadian rhythm and melatonin
- RNA modifications and cancer
- Receptor Mechanisms and Signaling
- Cancer-related gene regulation
- Pharmacological Receptor Mechanisms and Effects
- Computational Drug Discovery Methods
- Diet and metabolism studies
- Sleep and Wakefulness Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Prostate Cancer Treatment and Research
Harvard University
2019-2024
Massachusetts General Hospital
2019-2024
Athinoula A. Martinos Center for Biomedical Imaging
2019-2024
Medical University of the Americas
2019
Affective abstraction refers to how people conceptualize affective states in terms of category-level representations that generalize across specific situations (e.g., "fear" as evoked by heights, predators, and haunted houses). Here, we develop a novel task for assessing test its relations with trait alexithymia, depression, autism spectrum quotient. In preregistered online study, participants completed set tasks which they matched cue image one two probe images based on similarity...
The pathogenesis of Alzheimer’s disease (AD) is primarily driven by brain accumulation the amyloid-β-42 (Aβ42) peptide generated from amyloid-β precursor protein (APP) via cleavages β- and γ-secretase. γ-Secretase a prime drug target for AD; however, its regional expression distribution remain largely unknown. Here, we are aimed at developing molecular imaging tools visualizing We used our recently developed γ-secretase modulators (GSMs) synthesized GSM-based agent, [11C]SGSM-15606....
The sigma-1 receptor (σ1R) is a unique intracellular protein. σ1R plays major role in various pathological conditions the central nervous system (CNS), implicated several neuropsychiatric disorders. Imaging of brain using positron emission tomography (PET) could serve as noninvasively tool for enhancing understanding disease's pathophysiology. Moreover, PET tracers can be used target validation and quantification diagnosis. Herein, we describe radiosynthesis, vivo PET/CT imaging novel...
Here, we report the development of novel PET radiotracer ([11C]CW22) BET proteins. In vivo imaging results in rodents and nonhuman primates (NHP) demonstrate that [11C]CW22 has excellent brain uptake, good specificity, selectivity, suitable metabolism, appropriate kinetics distribution brain. Our studies demonstrated exhibits ideal properties as a probe proteins for further validation.
The orexin receptor (OX) is critically involved in motivation and sleep−wake regulation holds promising therapeutic potential various mood disorders. To further investigate the role of receptors (OXRs) living human brain to evaluate treatment orexin-targeting therapeutics, we herein report a novel PET probe ([11C]CW24) for OXRs brain. CW24 has moderate binding affinity (IC50 = 0.253 μM 1.406 OX1R OX2R, respectively) shows good selectivity over 40 other central nervous system (CNS) targets....
In this paper, we report the design, synthesis, and biological evaluation of first selective bromodomain extra-terminal domain (BET) BD1 bromodomains PET radiotracer [18F]PB006. The standard compound PB006 showed high affinity good selectivity toward BRD4 (Kd = 100 nM 29-fold selectively for over BD2) in an vitro binding assay. imaging experiments rodents were performed to evaluate bioactivity [18F]PB006 vivo. A biodistribution study mice revealed uptake peripheral tissues, such as liver...
Bromodomain and extra-terminal domain (BET) family proteins have become a research focus because of their close relationship with various diseases. With suitable imaging probe, the non-invasive technique, positron emission tomography (PET), provides powerful tool to visualize quantify BET that accelerating investigation this domain. Herein, we describe development promising PET [11C]1, specifically targeting based on potent inhibitor CF53. [11C]1 was successfully radio-synthesized good yield...
Alcohol use disorder (AUD) is a of clinical and public health significance requiring novel improved therapeutic solutions. Both environmental genetic factors play significant role in its pathophysiology. However, the underlying epigenetic molecular mechanisms that link gene-environment interaction AUD remain largely unknown. In this proof-of-concept study, we showed, for first time, neuroepigenetic biomarker capability non-invasive imaging class I histone deacetylase (HDAC) enzymes