A5037390723- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Prostate Cancer Treatment and Research
- Ubiquitin and proteasome pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Histone Deacetylase Inhibitors Research
Athinoula A. Martinos Center for Biomedical Imaging
2020
Harvard University
2020
Massachusetts General Hospital
2020
The pathogenesis of Alzheimer’s disease (AD) is primarily driven by brain accumulation the amyloid-β-42 (Aβ42) peptide generated from amyloid-β precursor protein (APP) via cleavages β- and γ-secretase. γ-Secretase a prime drug target for AD; however, its regional expression distribution remain largely unknown. Here, we are aimed at developing molecular imaging tools visualizing We used our recently developed γ-secretase modulators (GSMs) synthesized GSM-based agent, [11C]SGSM-15606....