A5100351220- Central Venous Catheters and Hemodialysis
- Vascular Procedures and Complications
- RNA modifications and cancer
- Genetic Associations and Epidemiology
- Multisensory perception and integration
- Cancer-related molecular mechanisms research
- Categorization, perception, and language
- Epigenetics and DNA Methylation
- Dialysis and Renal Disease Management
- Cancer, Hypoxia, and Metabolism
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Ferroptosis and cancer prognosis
- Topological Materials and Phenomena
- Genomics and Rare Diseases
- Noise Effects and Management
- Cancer, Lipids, and Metabolism
- Phagocytosis and Immune Regulation
- Vascular anomalies and interventions
- Extracellular vesicles in disease
- Plant Gene Expression Analysis
- Quantum Mechanics and Non-Hermitian Physics
- Spectroscopy Techniques in Biomedical and Chemical Research
- Autophagy in Disease and Therapy
- Retinopathy of Prematurity Studies
Peking University
2021-2025
Shandong Provincial QianFoShan Hospital
2024
Nanjing Medical University
2023-2024
Second Affiliated Hospital of Jilin University
2023
Boston University
2020-2023
Capital Medical University
2023
China Medical University
2023
Duke Kunshan University
2023
West China Hospital of Sichuan University
2023
Sichuan University
2019-2023
A primary obstacle in translating genetic associations with disease into therapeutic strategies is elucidating the cellular programs affected by risk variants and effector genes. Here, we introduce LipocyteProfiler, a cardiometabolic-disease-oriented high-content image-based profiling tool that enables evaluation of thousands morphological profiles can be systematically linked to genes relevant cardiometabolic disease. We show LipocyteProfiler allows surveillance diverse generating rich...
Plasma proteins are promising biomarkers and potential drug targets in lung cancer. To evaluate the causal association between plasma cancer, we performed proteome-wide Mendelian randomization meta-analysis (PW-MR-meta) based on cancer genome-wide studies (GWASs), protein quantitative trait loci (pQTLs) of 4,719 deCODE 4,775 Fenland. Further, causal-protein risk score (CPRS) was developed validated UK Biobank. 270 were identified using PW-MR meta-analysis, including 39 robust (both
During the COVID-19 pandemic, questions have been raised about impact of face masks on communication in classroom settings. However, it is unclear to what extent visual obstruction speaker's mouth or changes acoustic signal lead speech processing difficulties, and whether these effects can be mitigated by semantic predictability, i.e., availability contextual information. The present study investigated intelligibility speed under varying predictability. Twenty-six children (aged 8-12)...
The exosome is of vital importance throughout the entire progression cancer. Because lack effective biomarkers in ovarian cancer (OV), we intend to investigate connection between exosomes and tumor immune microenvironment verify that exosome-related genes (ERGs) can precisely forecast prognosis OV patients. First, 117 ERGs Cancer Genome Atlas (TCGA) dataset were recognized. Afterwards, risk signature consisting four with prognostic significance was built by univariate Cox, least absolute...
Summary A primary obstacle in translating genetics and genomics data into therapeutic strategies is elucidating the cellular programs affected by genetic variants genes associated with human diseases. Broadly applicable high-throughput, unbiased assays offer a path to rapidly characterize gene variant function thus illuminate disease mechanisms. Here, we report LipocyteProfiler, an high-content microscopy assay that amenable large-scale morphological profiling of lipid-accumulating cell...
Simple Summary Clinically, aberrant lipid metabolism is responsible for overweight and/or obesity. Overweight considered as an independent factor of cancer risk in 2019. Therefore, metabolic reprogramming emerging hallmark malignancy. It urgent need to comprehensively understand the relationship among and HNSCC identify a valuable biomarker predicting prognosis patients. Three new findings were found this study. Firstly, we identified lipid-related differentially expressed genes (DEGs) by...
Speech communication is multi-sensory in nature. Seeing a speaker's head and face movements may significantly influence the listeners' speech processing, especially when auditory information not clear enough. However, research on visual-auditory integration processing has left prosodic perception less well investigated than segmental perception. Furthermore, while native Japanese speakers tend to use visual cues other western languages, what extent are used focus by non-native listeners...
The seeds of Metasequia glyptostroboides Hu et Cheng, an endangered species, are susceptible to aging, making natural population renewal difficult and increasing the risk extinction. LncRNAs play important roles in plant growth development biotic abiotic stress responses, but functions lncRNAs aging process M. still unclear. In this study, we used single molecule real-time (SMRT) sequencing technology combination with Illumina RNA-seq analyze lncRNA changes during seed aging. We identified...
Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited cancer syndrome, and VHL identified as a tumor suppressor gene. The main objective of this study was to identify disease-causing mutations in Chinese family affected with disease. Genomic DNA extracted from peripheral blood VHL. A predicted pathogenic variant by targeted exome capture technology next-generation sequencing. novel heterozygous mutation (c.349 T > A, p.W117R) detected members. No unaffected members or the 150...
Background: Type 2 diabetes mellitus (T2DM), which has a high incidence and several harmful consequences, poses severe danger to human health. More research is being done on ferroptosis’ function in T2DM. This study uses bioinformatics technique look for new diagnostic T2DM biomarkers associated with ferroptosis. Methods: In order identify ferroptosis-related genes (DEGs) that are differently expressed between patients healthy individuals, we first obtained sequencing data (FRGs) from the...
Considering relatives' health history in logistic regression for case-control genome-wide association studies (CC-GWAS) may provide new information that increases accuracy and power to detect disease associated genetic variants. We conducted simulations analyzed type 2 diabetes (T2D) data from the Framingham Heart Study (FHS) compare two methods, liability threshold model conditional on both status family (LT-FH) Fam-meta, which incorporate into CC-GWAS.In our simulation scenario of trait...
Face masks can cause speech processing difficulties. However, it is unclear to what extent these difficulties are caused by the visual obstruction of speaker’s mouth or changes acoustic signal, and whether effects be found regardless semantic context. In present study, children adults performed a cued shadowing task online, repeating last word English sentences. Target words were embedded in sentence-final position manipulated visually, acoustically, context (cloze probability). First...
Abstract Health disparities have been reported between sexual minority and heterosexual populations, but no study investigated Phenotypic Age Acceleration (PhenoAgeAccel) among minority. To investigate differences in PhenoAgeAccel adults. In this cross-sectional study, 3061 participants from 2007–2010 National Nutrition Examination Survey (NHANES) included adults aged 20 to 59 years who self-identified as being heterosexual, gay, lesbian, bisexual or others. The main outcome was predicted...
Abstract Rare variants can explain part of the heritability complex traits that are ignored by conventional GWASs. The emergence large-scale population sequencing data provides opportunities to study rare variants. However, few studies systematically evaluate extent which imputation using improve power variant association studies. Using whole genome (WGS) (n = 150,119) as ground truth, we described landscape and evaluated consistency in SNP array 488,377) imputed from TOPMed or HRC+UK10K UK...