A5058873210- LGBTQ Health, Identity, and Policy
- Reproductive Health and Technologies
- RNA Research and Splicing
- Cancer-related molecular mechanisms research
- Single-cell and spatial transcriptomics
- Endometriosis Research and Treatment
- Cell Image Analysis Techniques
- Uterine Myomas and Treatments
- Chronic Kidney Disease and Diabetes
- Reproductive Health and Contraception
- Sexual Differentiation and Disorders
- Renal Diseases and Glomerulopathies
- RNA modifications and cancer
- Menstrual Health and Disorders
- Microplastics and Plastic Pollution
- Genetic and Kidney Cyst Diseases
- HIV/AIDS Research and Interventions
- Nanoparticles: synthesis and applications
- Adipokines, Inflammation, and Metabolic Diseases
- Hippo pathway signaling and YAP/TAZ
- Child Welfare and Adoption
- Genomics and Chromatin Dynamics
- Platelet Disorders and Treatments
- Sexual function and dysfunction studies
- Ubiquitin and proteasome pathways
Quinnipiac University
2021-2024
University of Minnesota
2024
Boston Children's Hospital
2024
Broad Institute
2021-2023
Massachusetts General Hospital
2016-2017
Harvard University
2016-2017
Center for Devices and Radiological Health
2014
A primary obstacle in translating genetic associations with disease into therapeutic strategies is elucidating the cellular programs affected by risk variants and effector genes. Here, we introduce LipocyteProfiler, a cardiometabolic-disease-oriented high-content image-based profiling tool that enables evaluation of thousands morphological profiles can be systematically linked to genes relevant cardiometabolic disease. We show LipocyteProfiler allows surveillance diverse generating rich...
Rho family GTPases, the prototypical members of which are Cdc42, Rac1, and RhoA, molecular switches best known for regulating actin cytoskeleton. In addition to canonical small large GTPase dynamin has been implicated in cytoskeleton via direct dynamin-actin interactions. The physiologic role linked maintenance kidney filtration barrier. Additionally, molecule Bis-T-23, promotes actin–dependent oligomerization thus, increases polymerization, improved renal health diverse models CKD,...
Summary Regulation of transcript structure generates diversity and plays an important role in human disease. The advent long-read sequencing technologies offers the opportunity to study genetic variation structure. In this paper, we present a large RNA-seq dataset using Oxford Nanopore Technologies platform from 88 samples GTEx tissues cell lines, complementing resource. We identified just under 100,000 new transcripts for annotated genes, validated protein expression similar proportion...
Summary A primary obstacle in translating genetics and genomics data into therapeutic strategies is elucidating the cellular programs affected by genetic variants genes associated with human diseases. Broadly applicable high-throughput, unbiased assays offer a path to rapidly characterize gene variant function thus illuminate disease mechanisms. Here, we report LipocyteProfiler, an high-content microscopy assay that amenable large-scale morphological profiling of lipid-accumulating cell...
Purpose: The purpose of this study was to assess the future family building desires assigned female at birth (AFAB) transgender and gender diverse (TGD) adolescents initiating hormone therapy, characterize individuals interested in adoption. Methods: This a retrospective chart review AFAB TGD ages 15-17 years old testosterone gender-affirming therapy between 2010 2019, analyzing interest adoption, demographics, care. Results: Of 195 asked about planning goals, 58% (n = 113) indicated desire...