A5047884192- Facial Nerve Paralysis Treatment and Research
- Adipokines, Inflammation, and Metabolic Diseases
- Single-cell and spatial transcriptomics
- Adipose Tissue and Metabolism
- Facial Rejuvenation and Surgery Techniques
- Tissue Engineering and Regenerative Medicine
- Cell Image Analysis Techniques
- Reconstructive Facial Surgery Techniques
- Urinary Bladder and Prostate Research
- Cancer Genomics and Diagnostics
- Ear Surgery and Otitis Media
- Meningioma and schwannoma management
- Spine and Intervertebral Disc Pathology
- Thyroid Cancer Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Trigeminal Neuralgia and Treatments
- Foot and Ankle Surgery
- Atherosclerosis and Cardiovascular Diseases
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Bioinformatics and Genomic Networks
- Botulinum Toxin and Related Neurological Disorders
Temple University
2024-2025
Massachusetts Eye and Ear Infirmary
2023-2024
Harvard University
2019-2024
Posnick Center for Facial Plastic Surgery
2024
Broad Institute
2021-2023
Beth Israel Deaconess Medical Center
2019
Center for Vascular Biology Research
2019
A primary obstacle in translating genetic associations with disease into therapeutic strategies is elucidating the cellular programs affected by risk variants and effector genes. Here, we introduce LipocyteProfiler, a cardiometabolic-disease-oriented high-content image-based profiling tool that enables evaluation of thousands morphological profiles can be systematically linked to genes relevant cardiometabolic disease. We show LipocyteProfiler allows surveillance diverse generating rich...
Introduction Low back pain is the most common type of chronic pain. We examined pain-related behaviors across 18 weeks in rats that received injury to one or two lumbar intervertebral discs (IVD) determine if multi-level disc injuries enhance/prolong Methods Twenty-three Sprague-Dawley adult female were used: 8 puncture (DP) IVD (L5/6, DP-1); DP IVDs (L4/5 & L5/6, DP-2); underwent sham surgery. Results DP-2 showed local (low back) sensitivity pressure at 6- and 12-weeks post-injury,...
Neurotrophic factors and reactive oxygen species (ROS) modulate neuronal plasticity. In a model of lower motor neuron lesioned bladder, somatic nerve transfer was used as reinnervation strategy. Levels neurotrophins, ROS, TNF-α in bladder mucosa muscle layers collected from three groups adult female dogs: (1) Decentralized, via bilateral transection coccygeal sacral spinal roots, lumbar 7 dorsal hypogastric nerves, then 6–21 mo recovery; (2) reinnervated (ObNT-Reinn), after similar...
Background: Several studies report smile improvements following depressor anguli oris (DAO) resection for patients with post-paralysis facial synkinesis. However, outcomes post-procedure are variable, and it is difficult to predict which will derive the greatest benefit. Methods: The medical records of all who underwent DAO from January 2021 June 2022 were retrospectively reviewed. Pre- post- procedure photographs analyzed using automated Emotrics software program, a blinded clinician-graded...
While there is great interest in selective neurectomy (SN) for patients with synkinesis, outcomes can be inconsistent.
Summary A primary obstacle in translating genetics and genomics data into therapeutic strategies is elucidating the cellular programs affected by genetic variants genes associated with human diseases. Broadly applicable high-throughput, unbiased assays offer a path to rapidly characterize gene variant function thus illuminate disease mechanisms. Here, we report LipocyteProfiler, an high-content microscopy assay that amenable large-scale morphological profiling of lipid-accumulating cell...
Brief summary: Emont et al. created a cell atlas of human and mouse white adipose tissue, which goes long way in informing our understanding the complexity tissue.
While there has been great interest in offering selective neurectomy (SN) to patients with nonflaccid facial palsy (NFFP), postoperative outcomes are inconsistent.
Abstract Background Cross face nerve grafting (CFNG) is a well‐established transfer technique in facial reanimation; however, no study has assessed outcome of supercharging the smile with CFNG patients synkinesis. The goal this was to examine non‐flaccid paralysis (NFFP) after during selective neurectomy. Methods NFFP who underwent end‐to‐side coaptation branch on paralyzed side neurectomy were retrospectively identified and their charts reviewed. Pre‐operative post‐operative function...
The introduction of ultra-precision targeted therapy has become a significant advancement in cancer therapeutics by creating treatments with less off target effects. Specifically papillary thyroid carcinoma (PTC), the cancer's hallmark genetic mutation BRAFV600E can be selective inhibitors, such as vemurafenib. Despite initial positive tumor responses regression and decreased viability, both single agent or combination drug provide pressure for resistant evolving clones within overall...
You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology (MP59)1 May 2024MP59-06 ENHANCED BRAIN-DERIVED NERVE FACTOR EXPRESSION AND REACTIVE OXYGEN SPECIES PRODUCTION IN MUCOSA OF LOWER MOTOR NEURON-LESIONED DOG BLADDER UNDERWENT SOMATIC-MOTOR TRANSFER Nagat Frara, Kais Jawawdeh, Istvan Pal Tamas, Ekta Tiwari, Alan S. Braverman, Ryan P. Gares, Elizabeth McGonagle, Lewis T. Holt-Bright, Michael R. Ruggieri, and Mary...
Gracilis free muscle transfer (GFMT) remains the standard for smile restoration in patients with long-standing facial palsy. Resting oral commissure lateralization (ROCL) following GFMT is aesthetically unappealing and can cause functional problems including dysarthria incompetence. The risk factors ROCL are poorly understood.
Facial nerve (FN) injury during a facelift is relatively rare but potentially devastating complication. Despite extensive literature discussing facial anatomy and danger zones, few studies describe detailed management, FN exploration intraoperative findings, outcome following post-facelift paralysis (PFFP). We review 20-year experience in managing iatrogenic PFFP.PFFP patients were retrospectively identified between 2002-2022. Demographic data, operative details from the procedure, function,...
ABSTRACT White adipose tissue (WAT), once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic, heterogenous, involved in a wide array of biological processes including energy homeostasis, glucose lipid handling, blood pressure control, host defense 1 . High fat feeding other metabolic stressors cause dramatic changes morphology, physiology, cellular composition , alterations adiposity are associated with insulin resistance, dyslipidemia, type 2...