A5102809609- Urinary Bladder and Prostate Research
- Tissue Engineering and Regenerative Medicine
- Urological Disorders and Treatments
- Pelvic floor disorders treatments
- Spinal Cord Injury Research
- Neuroscience of respiration and sleep
- Pediatric Pain Management Techniques
- Drug Transport and Resistance Mechanisms
- Urinary Tract Infections Management
- Anesthesia and Pain Management
- Veterinary Pharmacology and Anesthesia
- Congenital gastrointestinal and neural anomalies
- Muscle activation and electromyography studies
- Neuroscience and Neural Engineering
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine regulation and behavior
- Veterinary Medicine and Surgery
- Gastric Cancer Management and Outcomes
- Thermal Regulation in Medicine
- Inflammatory Biomarkers in Disease Prognosis
- Veterinary Orthopedics and Neurology
- Blood properties and coagulation
- Diet and metabolism studies
- Nicotinic Acetylcholine Receptors Study
- Pancreatic and Hepatic Oncology Research
Temple University
2016-2024
Brown University
2022-2024
Jawaharlal Nehru Medical College
2024
Jawaharlal Nehru Medical College Hospital
2024
Providence College
2024
Philadelphia University
2017-2019
In pilot work, we showed that somatic nerve transfers can restore motor function in long-term decentralized dogs. We continue to explore the effectiveness of reinnervation 30 female After anesthesia, 12 underwent bilateral transection coccygeal and sacral (S) spinal roots, dorsal roots lumbar (L)7, hypogastric nerves. Twelve months postdecentralization, eight transfer obturator branches pelvic vesical branches, sciatic pudendal nerves, followed by 10 mo recovery (ObNT-ScNT Reinn). The...
ABSTRACT Many studies examining the innervation of genitourinary structures focus on either afferent or efferent inputs, only one structure system. We aimed to clarify bladder, external urethral sphincter (EUS) and clitoris. Retrograde dyes were injected into each end organ in female dogs. Spinal cord, mid‐bladder, spinal, caudal mesenteric, sympathetic trunk pelvic plexus ganglia examined for retrograde dye‐labeled neurons. Neurons retrogradely labeled from bladder found primarily L7‐S2...
Previous patient surveys have shown that patients with spinal cord or cauda equina injuries prioritize recovery of bladder function. The authors sought to determine if nerve transfer after long-term decentralization restores and sphincter function in canines.
Aims Lumbar to sacral rerouting surgery can potentially allow voiding via a skin‐central nervous system‐bladder reflex pathway. Here, we assessed if this was effective in treating neurogenic bladder dysfunction/sphincter felines. Methods Eight cats underwent spinal cord transection (SCT) at thoracic level 10/11. Unilateral L7 S1 ventral root anastomosis performed 1 month later six cats. Two served as transection‐only controls. Electrical and manual stimulation of L6‐S1 dermatomes,...
This study determined the effect of pelvic organ decentralization and reinnervation 1 yr later on contribution muscarinic purinergic receptors to ex vivo, nerve-evoked, bladder smooth muscle contractions. Nineteen canines underwent by bilateral transection all coccygeal sacral (S) spinal roots, dorsal roots lumbar (L)7, hypogastric nerves. After exclusions, 8 were reinnervated 12 mo postdecentralization with obturator-to-pelvic sciatic-to-pudendal nerve transfers then euthanized 8-12 later....
We determined the effect of pelvic organ decentralization and reinnervation 1 yr later on urinary bladder histology function. Nineteen canines underwent by bilateral transection all coccygeal sacral (S) spinal roots, dorsal roots lumbar (L)7, hypogastric nerves. After exclusions, eight were reinnervated 12 mo postdecentralization with obturator-to-pelvic sciatic-to-pudendal nerve transfers, then euthanized 8-12 later. Four served as long-term decentralized only animals. Before euthanasia, or...
Spinal interneurons play a critical role in motor output. A given interneuron may receive convergent input from several different sensory modalities and descending centers relay this information to just as many targets. Therefore, there is need quantify populations of spinal simultaneously. Here, we the functional connectivity neurons through concurrent recording lumbar hindlimb units vivo cat model during activation either ipsilateral sural nerve or contralateral tibial nerve. Two...
Aims To assess bladder smooth muscle function and innervation after long‐term lower spinal root transection in canines. Methods Thirteen female mixed‐breed hound dogs underwent decentralization, which included of all sacral dorsal ventral roots caudal to L7 hypogastric nerves, bilaterally ( n = 3); nerves plus roots, 4); or a sham operation 6). At year initial surgery, was assessed vivo by stimulation the pelvic plexus. The tissue harvested for ex contractility studies. Remaining evaluated...
Very little is known about the physiological role of nicotinic receptors in canine bladders, although functional have been reported bladders many species. Utilizing vitro methods, we evaluated mediating bladder function dogs: control (9 female and 11 male normal controls, 5 sham operated), Decentralized females, decentralized 6-21 mo), obturator-to-pelvic nerve transfer reinnervated (ObNT-Reinn; 9 females; 9-13 mo, then with 8-12 mo recovery). Muscle strips were collected, mucosa-denuded,...
Objective We aimed to refine electroneurogram techniques for monitoring hypogastric nerve activity during bladder filling, and then examined in normal intact versus acutely decentralized bladders. Methods Effects of electrical stimulation nerves or lumbar ventral roots on detrusor pressure were examined, as effects isoflurane propofol anesthetics evoked pressure. Hypogastric was recorded using custom-made bipolar cuff electrodes filling before after its transection between the spinal cord...
Abstract AIM To evaluate the association of GDM and pre-eclampsia in women with obstetric cholestasis MATERIAL AND METHODS Pregnant >28weeks gestation attending ANC, OPD labour room J.N.M.C.H,AMU, Aligarh U.P (India) from 2020-2022 were included study after taking informed consent ethical approval Institute. Women divided into two groups ie group 1 having 200 IHCP 2 healthy pregnant women, both followed up for development pre-eclampsia. RESULTS A statistically significant was observed...
You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology (MP59)1 May 2024MP59-06 ENHANCED BRAIN-DERIVED NERVE FACTOR EXPRESSION AND REACTIVE OXYGEN SPECIES PRODUCTION IN MUCOSA OF LOWER MOTOR NEURON-LESIONED DOG BLADDER UNDERWENT SOMATIC-MOTOR TRANSFER Nagat Frara, Kais Jawawdeh, Istvan Pal Tamas, Ekta Tiwari, Alan S. Braverman, Ryan P. Gares, Elizabeth McGonagle, Lewis T. Holt-Bright, Michael R. Ruggieri, and Mary...
This study aimed to identify potential lateralization of bladder function. Electrical stimulation spinal roots or the pelvic nerve’s anterior vesical branch was performed bilaterally in female dogs. The percent difference between left and right stimulation-induced increased detrusor pressure determined. Bladders were considered right-sided if differences greater less than 25% 10%. Based on 25%, upon roots, bladders left-sided 17/44 (38.6%), 12/44 (27.2%) bilateral 15/44 (34.2%). Using ± 10%,...
31Aug 2016 CAUSES OF INCREASED MEAN PLATELET VOLUME IN MANGALORE REGION Ekta Tiwari , Saurabh Mishra Seema Nagar and Bharti Bhandari.
Objective: We demonstrated motor reinnervation of the decentralized canine urinary bladder by increased detrusor pressure induced electrical stimulation transferred genitofemoral or femoral nerves in 21 28 animals. previously reported evidence and bowel fullness sensation these new neuronal pathways based on observation micturition defecation postures reinnervated Our focus here was to determine whether are eliminated Methods: The pelvis bilateral transection hypogastric all spinal nerve...
Objective: Our goal was to determine whether electrical stimulation of the hypogastric nerve in dogs with intact bladder innervation results contraction detrusor muscle bladder. The effects anesthetics isoflurane versus propofol on pressure were compared. Methods: A total 14 female mixed-breed hounds innervation, body mass 20–25 kg and 6–8 months age used. Maximum changes pressures determined following (3–10 mA, 20 Hz) nerves under inhalation anesthesia at 1–3% mean alveolar concentration...
Objective: We previously found that intravenous succinylcholine, a depolarizing neuromuscular nicotinic receptors blocker, prevents bladder contractions induced by new neuronal pathways established nerve transfer in decentralized dogs. studied the detrusor pressure response vivo and contractile of smooth muscle strips vitro from sham, reinnervated animals to localize involved. Methods: Three groups female mongrel hound dogs were used: sham (N=4), 12-month (N=3) 6-month (N=3)....
Objective: Surgical rerouting of neuronal pathways may allow functional reinnervation the bladder. We aim to develop techniques monitor afferent (sensory) nerve activity during bladder filling in normal intact bladders for eventual application monitoring sensory following transfer. Methods: Electroneurogram recordings were performed anesthetized rats under isoflurane (1–2% induction dose, inhalation) of: (I) sciatic nerves stimulation hindpaw with Semmes-Weinstein monofilaments varying...
Objective: Somatic nerve transection causes rapid loss of skeletal muscle mass and contractility. While degeneration following injury has been well investigated, less is known about the effects autonomic on smooth muscle. We explored changes in nerve-smooth functional unit sacral root decentralization to determine integrity after decreased innervation. Methods: Female mixed-breed hound dogs were surgically decentralized by bilateral all spinal roots caudal L7, including dorsal L7 a subgroup....