A5040665415- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Urological Disorders and Treatments
- Urinary Tract Infections Management
- Anorectal Disease Treatments and Outcomes
- Ureteral procedures and complications
- Pediatric Urology and Nephrology Studies
- Botulinum Toxin and Related Neurological Disorders
- Prostate Cancer Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Sexual function and dysfunction studies
- Tissue Engineering and Regenerative Medicine
- Urologic and reproductive health conditions
- Cardiovascular Syncope and Autonomic Disorders
- Prostate Cancer Treatment and Research
- Hernia repair and management
- Surgical Simulation and Training
- Colorectal Cancer Surgical Treatments
- Stoma care and complications
- Pressure Ulcer Prevention and Management
- Innovations in Medical Education
- Health Systems, Economic Evaluations, Quality of Life
- Diverticular Disease and Complications
- Clinical Reasoning and Diagnostic Skills
- Spinal Cord Injury Research
McGill University
2014-2023
Jewish General Hospital
2013-2023
Marymount University
2013
McGill University Health Centre
2010
Université de Montréal
1993-2009
Hôpital Saint-Luc
2009
Institut Universitaire de Gériatrie de Montréal
2006-2009
Centre for Interdisciplinary Research in Rehabilitation
2009
Shriners Hospitals for Children - Canada
2007
National University Hospital
2007
OBJECTIVE To ascertain the prevalence of lower urinary tract symptoms (LUTS) and incontinence (UI) in Canada, using a cross‐Canada telephone survey, as there is wide discrepancy reported these conditions. SUBJECTS AND METHODS A random survey with standardized questionnaire was conducted to elicit responses from 1000 adults, aged ≥ 18 years; sample intended reflect population census. Data on age, level education household income were obtained all respondents. All participants questioned about...
No AccessJournal of UrologyAdult Urology1 Jun 2011Efficacy Botulinum Toxin A Injection for Neurogenic Detrusor Overactivity and Urinary Incontinence: Randomized, Double-Blind Trial Sender Herschorn, Jerzy Gajewski, Karen Ethans, Jacques Corcos, Kevin Carlson, Gregory Bailly, Robert Bard, Luc Valiquette, Richard Baverstock, Lesley Carr, Sidney Radomski HerschornSender Herschorn University Toronto, Ontario, Canada Financial interest and/or other relationship with Astellas, Allergan, Pfizer,...
The overactive bladder (OAB) picture has dramatically changed in the last 20 years. A quarter century ago, this symptom complex did not even exist. Bladder hyperactivity and urgency incontinence were separate entities poorly understood treated only with first-generation anti-muscarinic medications, propantheline oxybutynin. Only early 2000 came concept of syndrome made four intimately linked symptoms that we today call OAB. With concept, new pharmacological agents launched. These may have...
investigation and treatment, as per the modified Oxford Centre for Evidence-Based Medicine grading system.Where literature was inconsistent or scarce, a consensus expert opinion generated to provide treatment guidelines.
A dult urinary incontinence (UI) is a highly prevalent condition, and one which can have major impact on patients' quality of life.It also focus urologist's workload.As result, the Canadian Urological Association (CUA), with aid its Guidelines Committee, commissioned development practice guideline document in 2005 first authored by Dr. Jacques Corcos.
Urethral duplication is a rare congenital anomaly. The clinical presentation varies because of the different anatomical patterns this abnormality. We describe our experience with 16 male patients anomaly.We retrospectively reviewed records treated for urethral in last 10 years. Age at ranged from newborn to 8 Evaluation included ultrasound, voiding cystourethrography, retrograde urethrography and endoscopy.A blind ending duplicated urethra (type I) was present 4 patients, 2 independent...
We assessed the generation of vesicoureteral reflux before and after injection botulinum toxin A into trigone patients with nonneurogenic overactive bladder, evaluated its short-term efficacy.Adults bladder resistant to behavioral treatments, pelvic floor exercises, medication neuromodulation were included in study. The initial evaluation (history, physical examination, 3-day urinary diary, V8 score, flowmetry post-void residual) was repeated 6 weeks injection. Videourodynamic study...
We evaluated the effect of repeated intradetrusor injections BTA in pediatric myelomeningocele not responding to medical management.After baseline history, physical examination and urodynamic assessment was injected (5 IU/kg body weight, maximum 300 IU) at 10 30 sites. Clinical performed 3 months after each injection. Re-treatment offered when clinical symptoms returned.A total 20 patients (average age 13 years) received injections. Of became continent. MBC increased from 215.6 +/- 58.8 cc...
To investigate the interaction between, and significance of, ERG gene rearrangements PTEN genomic deletions in relation to development progression of prostate cancer (PCA).We interrogated an initial cohort 220 men with localized PCA using fluorescence situ hybridization for deletions.The incidences were significantly higher than high-grade prostatic intra-epithelial neoplasia (HGPIN) benign tissue (P < 0.001). detected 41.9 42.6% patients' tumours, respectively. never tissue, while...
Abstract Purpose: Prostate cancer metastasis to secondary organs is considered an initial event in the development of hormone refractory disease and remains major cause death among prostate patients. In this study, we investigated role fascin, a cytoskeleton actin–bundling protein involved formation filopodia cell migration, progression. Experimental Design: Fascin expression was examined by immunohistochemistry cohort 196 patients with localized across several stages progression, including...
The AMS800™ device, by far the most frequently implanted artificial urinary sphincter (AUS) worldwide, is considered to be "gold-standard" when male incontinence surgical treatment contemplated. Despite 40 years of experience, it still a specialized procedure with number challenges. Here, we present recommendations issued from AUS Consensus Group, regarding indications, management, and follow-up implantation or revision.Under ICS auspices, an expert panel met on July 10, 2015 in Chicago, IL,...
OBJECTIVES To evaluate the efficacy, tolerability and safety of a flexible‐dosing strategy with darifenacin, an M 3 ‐selective receptor antagonist, in patients symptoms overactive bladder (OAB). PATIENTS AND METHODS In this multicentre double‐blind 12‐week study, 395 (aged 22–89 years; 84% female) OAB for >6 months were randomized (2 : 1) received once‐daily treatment darifenacin controlled‐release tablets 7.5 mg (268 patients) or matching placebo (127). After 2 weeks treatment, assessed...
In a pivotal trial we evaluated the effectiveness and safety of Macroplastique(R) as minimally invasive endoscopic treatment for female stress urinary incontinence primarily due to intrinsic sphincter deficiency.A total 247 females with deficiency were randomized 1:1 treated transurethral injection Macroplastique or Contigen. The latter group served control. Repeat was allowed after 3-month followup. Effectiveness determined 12 months last using Stamey grade, pad weight Urinary Incontinence...
Abstract Objective To assess the effect of intra‐sphincteric injections bone marrow mesenchymal stromal cells (MSCs) on Valsalva leak point pressure (VLPP) changes in an animal model stress urinary incontinence (SUI). Materials and Methods Twenty‐four female Sprague–Dawley rats underwent bilateral pudendal nerve section to induce SUI. Six were SUI controls, 6 received periurethral injection Plasma‐Lyte (SUI placebo control) 12 given PKH26‐labeled MSCs. Four weeks after injection, conscious...
We evaluated the durability of urethral bulking agent Macroplastique for stress urinary incontinence in a 24-month study women with previously documented successful outcome 12 months after last injection.In multicenter females diagnosed primarily due to intrinsic sphincter deficiency successfully treated Macroplastique, defined as 1 or greater Stamey grade improvement from baseline, were followed 24 assess sustained therapeutic response. Outcome measures grade, Patient Global Impression...