A5061032874- Muscle Physiology and Disorders
- Genetic Neurodegenerative Diseases
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Gene expression and cancer classification
- CRISPR and Genetic Engineering
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Diet and metabolism studies
- Diabetes and associated disorders
- Genomics and Phylogenetic Studies
- Mitochondrial Function and Pathology
- Bone health and treatments
- Glycogen Storage Diseases and Myoclonus
- Cancer Research and Treatments
- Peptidase Inhibition and Analysis
- Cancer Genomics and Diagnostics
- interferon and immune responses
- Single-cell and spatial transcriptomics
- Parathyroid Disorders and Treatments
- Genomics and Chromatin Dynamics
- Virus-based gene therapy research
- Mesenchymal stem cell research
Centre de Recherche en Myologie
2022-2023
Sorbonne Université
2015-2023
Institut de Myologie
2022-2023
Inserm
2018-2023
Centre de Recherche des Cordeliers
2018
Sorbonne Paris Cité
2018
Université Paris Cité
2018
Max Planck Institute for Heart and Lung Research
2017
Université Claude Bernard Lyon 1
2015
Centre National de la Recherche Scientifique
2015
The annotation of genomic ranges interest represents a recurring task for bioinformatics analyses. These can originate from various sources, including peaks called transcription factor binding sites (TFBS) or histone modification ChIP-seq experiments, chromatin structure and accessibility experiments (such as ATAC-seq), but also other types predictions that result in ranges. While peak primarily driven by ChiP-seq was extensively explored, many approaches remain simplistic ("most closely...
Hypertrophic white adipose tissue (WAT) represents a maladaptive mechanism linked to the risk for developing type 2 diabetes in humans. However, molecular events that predispose WAT hypertrophy are poorly defined. Here, we demonstrate adipocyte is triggered by loss of corepressor GPS2 during obesity. Adipocyte-specific deficiency mice (GPS2 AKO) causes hypertrophy, inflammation, and mitochondrial dysfunction surplus energy. This phenotype driven HIF1A activation orchestrates inadequate...
Skeletal muscle is a highly plastic tissue composed of number heterogeneous cell populations that, by interacting and communicating with each other, participate to the homeostasis, orchestrate regeneration repair in healthy diseased conditions. Although relies on activity stem cells (MuSCs), many other cellular players such as inflammatory, vascular tissue-resident mesenchymal communicate MuSCs sustain regenerative process. Among them, Fibro-Adipogenic Progenitors (FAPs), interstitial...
Myotonic dystrophy type 1 (DM1) is a neuromuscular disease that originates from an expansion of CTG microsatellites in the 3' untranslated region DMPK gene, thus leading to expression transcripts containing expanded CUG repeats (CUGexp). The pathophysiology explained by toxic RNA gain function where CUGexp RNAs form nuclear aggregates sequester and alter MBNL splicing factors, triggering misregulation linked DM1 symptoms. There currently no cure for DM1, most therapeutic strategies aim at...
Abstract Background Quantification of tumor heterogeneity is essential to better understand cancer progression and adapt therapeutic treatments patient specificities. Bioinformatic tools assess the different cell populations from single-omic datasets as bulk transcriptome or methylome samples have been recently developed, including reference-based reference-free methods. Improved methods using multi-omic are yet be developed in future community would need systematic perform a comparative...