A5038297631- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Education and Learning Interventions
- Educational Research and Pedagogy
- Psychosocial Factors Impacting Youth
- Education, Safety, and Science Studies
- Grit, Self-Efficacy, and Motivation
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced biosensing and bioanalysis techniques
- Education, Achievement, and Giftedness
- Creativity in Education and Neuroscience
- Quantum Dots Synthesis And Properties
- Educational Systems and Policies
- Magnetism in coordination complexes
- Crystal structures of chemical compounds
- Metal complexes synthesis and properties
- Monoclonal and Polyclonal Antibodies Research
- Fungal Biology and Applications
- Healthcare Education and Workforce Issues
- Covalent Organic Framework Applications
- HER2/EGFR in Cancer Research
- Porphyrin and Phthalocyanine Chemistry
- Luminescence and Fluorescent Materials
- Nanoplatforms for cancer theranostics
- Molecular Sensors and Ion Detection
Hallym University Dongtan Sacred Heart Hospital
2023
Korea Advanced Institute of Science and Technology
2010-2021
Institut Pasteur Korea
2008-2021
Seoul National University
2003-2021
Seoul National University Bundang Hospital
2019-2021
Kyung Hee University
2021
Seoul Institute
2019
Halla University
2019
Duksung Women's University
2017-2018
Inje University Haeundae Paik Hospital
2018
The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and in vivo stability. Yet few efforts have been made to critically examine the structure its effect on cell–particle interaction. Here we develop a microfluidic chip allowing synthesis structurally well-defined lipid-polymer same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force...
Multimodal nanoparticles have been extensively studied for target-specific imaging and therapy of various diseases, including cancer. In this study, radiolabeled arginine-glycine-aspartic acid (RGD)–functionalized Er<sup>3+</sup>/Yb<sup>3+</sup> co-doped NaGdF<sub>4</sub> upconversion nanophosphors (UCNPs) were synthesized evaluated as a multimodal PET/MR/optical probe with tumor angiogenesis–specific targeting properties. <b>Methods:</b> A dimeric cyclic RGDyk ((cRGDyk)<sub>2</sub>) peptide...
Synthesis of nanomaterials with multi-imaging modality is great importance in clinical molecular imaging and diagnostics. This work reports novel synthetic strategy to create ultrasmall hexagonal upconversion nanoparticles (UCNPs), β-NaGdF4: Yb3+, Er3+, Tm3+, inherent magnetic efficient properties. The use new combination lanthanide chloride sodium TFA as the precursors for UCNPs gave best results terms size (10−40 nm), crystallinity morphology, proved be cost- time-saving. Water...
Co-immunoprecipitation (co-IP) has become a standard technique, but its protein-band output provides only static, qualitative information about protein-protein interactions. Here we demonstrate real-time single-molecule co-IP technique that generates videos of individual interactions as they occur in unpurified cell extracts. By analysing single Ras-Raf with 50-ms time resolution, have observed transient intermediates the interaction and determined all essential kinetic rates. Using this...
A new coordination polymer containing a tetranuclear Cu(II)-btp unit is an effective heterogeneous catalyst for the regioselective ring opening of epoxide by methanol.
The structures of new polymeric compounds containing Cu(II) ions and btp (2,6-bis(N′-1,2,4-triazolyl)pyridine) ligands have been determined. bridge to form double zigzag chains, [Cu(ClO4)2(btp)2] 3 with perchlorate anions, single [Cu(btp)(H2O)4](SO4)·2H2O 4 sulfate anions. compound was found effectively catalyze the epoxide ring-opening reaction methanol, while almost inactive epoxides under same conditions. showed an efficient catalytic activity regioselective reactivity in ring opening...
Ni–nitrilotriacetic acid (NTA) functionalized CdSe/ZnS quantum dots (QDs) were exploited as a site-specific labeling agent of histidine-tagged biomolecules in live cells; the QDs found to be water-soluble, aggregation free and stable for several months.
Neuronal SNARE proteins mediate neurotransmitter release at the synapse by facilitating fusion of vesicles to presynaptic plasma membrane. Cognate v-SNAREs and t-SNAREs from vesicle membrane, respectively, zip up bring about apposition two membranes attached C-terminal ends. Here, we demonstrate that zippering can be modulated in midways wedging with small hydrophobic molecules. Myricetin, which intercalated into inner core near middle complex, stopped motion accumulated trans -complex,...
Imaging of specific mRNA targets in cells is great importance understanding gene expression and cell signaling processes. Subcellular localization known as a universal mechanism for to sequester high production required proteins. Various expressions Drosophila are studied using quantum dots (QDs) the fluorescence situ hybridization (FISH) method. The excellent photostability highly luminescent properties QDs compared conventional fluorophores allows reproducible obtainment quantifiable...
Successive chromatography of EtOAc-soluble extracts the fruiting body Sparassis crispa (Wulf.) resulted in isolation four new aromatic compounds, sparoside A (1) and sparalides A-C (3-5), two naturally occurring 2 6, eight known 7-14. The chemical structures were determined by interpretation nuclear magnetic resonance mass spectrometry spectroscopic data. Extract, solvent-soluble fractions extract, all pure compounds isolated from subjected to mRNA expression assay for proprotein convertase...
Abstract Background Malaria infects over 300 million people every year and one of the major obstacles for eradication disease is parasite's resistance to current chemotherapy, thus new drugs are urgently needed. Quantum dot (QD) a fluorescent nanocrystal that has been in spotlight as robust tool visualization live cell processes real time. Here, simple efficient method using QD directly label Plasmodium falciparum -infected erythrocytes (iRBCs) was searched order use probe an anti-malarial...
Four new lanostane-type triterpenes were isolated from the MeOH extract of fruiting bodies Ganoderma applanatum. Their structures established as 3β,7β,20,23ξ-tetrahydroxy-11,15-dioxolanosta-8-en-26-oic acid (1), 7β,20,23ξ-trihydroxy-3,11,15-trioxolanosta-8-en-26-oic (2), 7β,23ξ-dihydroxy-3,11,15-trioxolanosta-8,20E(22)-dien-26-oic (3), and 7β-hydroxy-3,11,15,23-tetraoxolanosta-8,20E(22)-dien-26-oic methyl ester (4), respectively, by extensive spectroscopic analyses.
The generation of compact quantum dots (QDs) probes is critical importance for visualizing molecular interaction occurring in biological context, particularly when using the Förster resonance energy transfer (FRET) approach. This Article reports novel water-soluble CdSe/ZnS QDs prepared by ligand exchange reaction thiolated nitrilotriacetate (NTA). resulting NTA-QDs revealed higher stability and remarkable conjugation efficiency compared to other with different ligands method. Ni-NTA group a...
We developed a single-cell version of the co-immunoprecipitation (co-IP) analysis that examines amount and protein–protein interactions target proteins immunoprecipitated from individual cells.
Adverse drug reactions (ADRs) pose a global public health threat, substantially contributing to death. Due the relative paucity of clinical evidence regarding fatal ADRs, this study was performed characterize epidemiology ADRs in Korea. This retrospective, cross-sectional analysis ADR cases reported Korea Event Reporting System from 2010 2019. All were coded using World Health Organization-Adverse Reaction Terminology system and classified as either or non-fatal events. Logistic regression...
New nickel complexes containing novel tetradentate ligands, 4,5-substituted-1,2-bis(pyridine-2-carboxamide)-benzene ligands but lacking alkyl or halide in the coordination sphere have been prepared. They were activated with MMAO (modified methylaluminoxane) to be proven as efficient catalysts for polymerization of norbornene. Both electron-donating and -withdrawing substituents on benzene ring polar solvents enhance catalytic activity olefin polymerization. Improvement thermal stability was...