A5017913185- Radiopharmaceutical Chemistry and Applications
- MicroRNA in disease regulation
- Nanoplatforms for cancer theranostics
- Healthcare cost, quality, practices
- Immune cells in cancer
- Radiation Therapy and Dosimetry
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Cells and Metastasis
- Hernia repair and management
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Hip and Femur Fractures
- Single-cell and spatial transcriptomics
- Lysosomal Storage Disorders Research
- COVID-19 and healthcare impacts
- Autophagy in Disease and Therapy
- Cell Image Analysis Techniques
- Pelvic and Acetabular Injuries
- Ferroptosis and cancer prognosis
Ajou University
2024-2025
Weill Cornell Medicine
2017
Cornell University
2017
Abstract Nicotinamide phosphoribosyltransferase (NAMPT) is a metabolic enzyme with key roles in inflammation. Previous studies have examined the consequences of its upregulated expression cancer cells themselves, but are limited respect to role other within tumor microenvironment (TME) during colorectal (CRC) progression. Using single‐cell RNA sequencing (scRNA‐seq) data, it founded that NAMPT highly expressed SPP1 + tumor‐associated macrophages (TAMs), unique subset TAMs associated...
Hepatocellular carcinoma (HCC) is characterized by high recurrence and mortality, necessitating the identification of reliable biomarkers. In this study, we aimed to identify predictive gene signatures for HCC evaluate efficiency GULP PTB domain-containing engulfment adaptor 1 (GULP1) as a diagnostic marker therapeutic target HCC. We analyzed genomic datasets from The Cancer Genome Atlas Gene Expression Omnibus databases via least absolute shrinkage selection operator Cox regression 10-fold...
Hepatocellular carcinoma (HCC) is known to be lethal disease. However, its prognosis remains poor, primarily because the precise oncogenic mechanisms underlying HCC progression remain elusive, thus hampering effective treatment. Here, we aimed identify potential oncogenes in and elucidate of their action. To candidate genes, an integrative analysis eight publicly available genomic datasets was performed, functional implications identified genes were assessed vitro vivo. Sortilin 1 (SORT1) as...
Hepatocellular carcinoma (HCC) presents a major health issue worldwide. This study introduces the HepScope gene set, developed through hybrid approach that utilizes single-cell RNA sequencing (scRNA-seq), spatial transcriptomics (stRNA-seq), bulk RNA-seq, and proteomics data, along with adaptation of Convolutional Neural Network (CNN) techniques. Comprising 113 genes significantly upregulated in malignant hepatocytes, set includes 77 unique to this compared other HCC-related sets. Unlike...