A5053853422- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Colorectal Cancer Screening and Detection
- Gastrointestinal Tumor Research and Treatment
- Gallbladder and Bile Duct Disorders
- Nanoplatforms for cancer theranostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Gastroesophageal reflux and treatments
- Pancreatic and Hepatic Oncology Research
- Photodynamic Therapy Research Studies
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Pediatric Hepatobiliary Diseases and Treatments
- Photochromic and Fluorescence Chemistry
- Clostridium difficile and Clostridium perfringens research
- Hepatitis B Virus Studies
- Genetic factors in colorectal cancer
- Gastrointestinal motility and disorders
- Biliary and Gastrointestinal Fistulas
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
Ajou University
2016-2025
Yahoo (United Kingdom)
2023
Ajou University Hospital
2018-2021
Objectives: Recurrence of primary common bile duct (CBD) stone commonly occurs after complete removal CBD stones in patients with cholecystectomy. This study aimed to investigate potential risk factors for the recurrence endoscopic treatment.Materials and methods: Between January 2005 December 2015, retrograde cholangiopancreatography (ERCP) database our medical center was retrospectively reviewed; information regarding eligible who had recurrent a history previous cholecystectomy collected....
Abstract Genomic alterations in tumors play a pivotal role determining their clinical trajectory and responsiveness to treatment. Targeted panel sequencing (TPS) has served as key tool over the past decade, but advancements costs bioinformatics have now made whole-genome (WGS) feasible single-assay approach for almost all cancer genomes settings. This paper reports on findings of prospective, single-center study exploring real-world utility WGS (tumor matched normal tissues) two primary...
γ-Glutamyltransferase (GGT) plays a role in cleaving the γ-glutamyl bond of glutathione. The GGT is known to be overexpressed some tumors and has been recognized as potential biomarker for malignant tumors. Colon cancer one most common cancers worldwide; however, there no quantitative method detecting cells human colon tissues. In this study, we report ratiometric two-photon probe that can applied (Probe 2) showed high fluorescence efficiency, marked changes, excellent kinetics, selectivity...
Background: Endoscopic submucosal dissection (ESD) is a representative treatment modality for early gastric neoplasms. However, the learning curve beginners performing ESD using multibending endoscope has not been introduced. Objective: This study aimed to evaluate curves of operators undergoing intensive training endoscope. Design: was retrospective single center study. Methods: We retrospectively analyzed data over 1500 consecutive ESDs performed by two A change-point analysis with 50...
Although the urea breath test (UBT) is widely used as a representative monitoring after Helicobacter pylori eradication, false-negative results can occur because of gray zone related to its cutoff value. This study aimed compare diagnostic performances rapid urease (RUT), RUT with sweeping method, and UBT, investigate role method in UBT values. We retrospectively reviewed 216 patients who received standard first-line H. eradication treatments (n=216). All participants underwent testing using...
Background/Aim: Epithelial cell adhesion molecule (EpCAM) is expressed in hepatic progenitor cells and hepatocellular carcinoma (HCC), considered a marker of liver cancer stem cells. Materials Methods: A total 262 patients were enrolled who had undergone surgical resection for HCC, with immunohistochemical staining results EpCAM. The expression EpCAM other stemness-related markers was evaluated as prognosticators tumor recurrence survival underwent HCC. Results: multivariate Cox regression...
Abstract Background and Aim Circulating microRNA (miR)‐122 has recently been investigated as a potential biomarker of various hepatic diseases, such chronic hepatitis hepatocellular carcinoma (HCC). We the association between plasma miR‐122 levels treatment outcomes following transarterial chemoembolization (TACE) in HCC patients. Methods included 177 patients treated with TACE study; refractoriness liver transplantation‐free survival were evaluated during follow up. Pretreatment assessed...
The pathophysiology of functional abdominal bloating and distention (FABD) is unclear yet. Our aim to compare the diversity composition fecal microbiota in patients with FABD healthy individuals, evaluate relationship between small intestinal bacterial overgrowth (SIBO) dysbiosis.The samples was analyzed from 33 subjects, including 12 controls 21 diagnosed by Rome IV criteria. underwent a hydrogen breath test. Fecal determined 16S ribosomal RNA amplification sequencing.Overall group differed...
Bile acid (BA) is a crucial determinant of the gut microbiome, and cholecystectomy can alter physiology BA. Physiological changes in BA resulting from also influence microbiome. We aimed to identify specific taxa associated with perioperative symptoms, including postcholecystectomy diarrhea (PCD), evaluate effect on microbiome by investigating fecal patients gallstones.We analyzed samples 39 gallstones (GS group) 26 healthy controls (HC their collected GS group 3 months postcholecystectomy....
Stomach cancer is a global health issue because of its incidence and mortality rates worldwide. We developed near-infrared (NIR) emissive ratiometric two-photon (TP) probe (HCC1) for the quantitative analysis pH in live cells human stomach tissues. The design based on restrained hemicyanine core that controls intramolecular charge transfer from 2-naphthol, with suitable pKa value (7.50) under physiological conditions. exhibited improved quantum yield, stability, TP activity In addition,...
Early post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) prediction may allow safe same-day outpatients discharge after ERCP and earlier proper management.This study aimed to assess the usefulness of 4-hour post-ERCP serum amylase lipase levels for PEP early investigate predictive cut-off values urgent initiation resuscitation.The data 516 consecutive patients with native papilla who underwent between January 2013 August 2014 were retrospectively reviewed.Serum...
Acidified extracellular pH (pHe) is directly related to various disorders such as tumor invasion and the resistance drugs. In this study, we developed two-photon-excitable emission ratiometric probes (XBH1–3) for in situ measurement of pHe. These probes, based on benzimidazole polar solubilizing groups, exhibited a strong two-photon-induced fluorescence sensitive blue-to-green color changes with pKa values 5.1–5.7. XBH1, containing carboxylic acid, stained region neutral media; it entered...
Colorectal cancer is a major cause of cancer-related deaths worldwide. Histologic diagnosis using biopsy samples colorectal neoplasms the most important step in determining treatment methods, but these methods have limitations accuracy and effectiveness. Herein, we report dual-recognition two-photon probe its application discrimination between human neoplasms. The composed two monosaccharides, d-glucosamine β-d-galactopyranoside, fluorophore for monitoring both glucose uptake β-gal...
Although the rapid urease test (RUT) is a simple method for detecting Helicobacter pylori (H. pylori) infection, it requires sufficient biopsy samples and its sensitivity varies depending on site condition of H. infection. We compared diagnostic performance "sweeping method" detection with conventional sampling in atrophic gastric conditions which can reduce RUT accuracy. This prospective study included 279 patients who underwent upper endoscopy to determine presence Gastric mucosa both...
We aimed to evaluate the survival benefits of coadministering statins and multityrosine kinase inhibitors (TKIs) in patients with advanced hepatocellular carcinoma (HCC). Data from Health Insurance Review Assessment Service Korea (2010–2020) were utilized. Statin use (≥28 cumulative defined daily doses) was analyzed, 1534 statin users matched 6136 non-users (1:4 ratio) using propensity scores. Primary secondary outcomes overall (OS) progression-free (PFS). significantly improved OS (hazard...
Background/Aims: Adequate bowel preparation is important for successful colonoscopy.We aimed to evaluate the clinical feasibility and effectiveness of abdominal vibration stimulation in before therapeutic colonoscopy.Methods: A single center, prospective, randomized, investigator-blinded study was performed between January 2016 December 2016.Patients colonoscopy were prospectively enrolled assigned either vibrator group or walking group.Patients who refused participate this as part...