A5004800779- Nerve injury and regeneration
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Tissue Engineering and Regenerative Medicine
- Wound Healing and Treatments
- Nerve Injury and Rehabilitation
- Shoulder Injury and Treatment
- Peripheral Nerve Disorders
- 3D Printing in Biomedical Research
- Musculoskeletal synovial abnormalities and treatments
- Electrospun Nanofibers in Biomedical Applications
- Corneal Surgery and Treatments
- Tendon Structure and Treatment
- Foot and Ankle Surgery
- Neuroscience and Neural Engineering
- Dupuytren's Contracture and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Rabies epidemiology and control
- Organ Donation and Transplantation
- Surgical Sutures and Adhesives
- Mesenchymal stem cell research
- Reconstructive Surgery and Microvascular Techniques
- Orthopaedic implants and arthroplasty
- Neurofibromatosis and Schwannoma Cases
- Bone Tissue Engineering Materials
Kyoto University
2019-2024
Kyoto University Hospital
2023
Saga University
2021
Kyoto University of Education
2021
JR Tokyo General Hospital
2018
Abstract Although autologous nerve grafting is widely accepted as the gold standard treatment for segmental defects, harvesting nerves highly invasive and leads to functional loss of ablated part. In response, artificial conduits made materials have been reported, but efficacy regeneration still needs improvement. The purpose this study investigate mechanism Bio three-dimensional (3D) conduit composed xeno-free human induced pluripotent stem cell–derived mesenchymal cells (iMSCs). 5-mm gap...
Previously, we developed a Bio3D conduit fabricated from human fibroblasts and reported significantly better outcome compared with artificial nerve in the treatment of rat sciatic defect. The purpose this study is to investigate long-term safety regeneration treatments using autologous transplantation.We used 15 immunodeficient rats randomly divided them into three groups treated (
Abstract Background The reduction of systemic immunosuppressive agents is essential for the expansion vascularized composite allotransplantation (VCA) in a clinical setting. purpose this study to compare human‐induced pluripotent stem cell‐derived mesenchymal cells (iMSCs) with four other types (human bone marrow‐derived MSCs [BMMSCs], human adipose‐derived [ADMSCs], rat BMMSCs, and ADMSCs) vitro, investigate vivo immunomodulatory effect iMSCs VCA model. Materials methods One Brown Norway...
We previously reported that a nerve conduit created from fibroblasts promotes regeneration in rat sciatic model. This study aims to determine whether bone marrow stromal cells (BMSCs) can promote regeneration. Primary BMSCs were isolated femur of two Lewis rats, and at passages 4–7 used. seven Bio 3D conduits using Bio-3D Printer. The transplanted other rats bridge 5-mm right gaps (Bio group, n = 7). control groups: silicone group (S 5) which the same gap was bridged with tube, cell (SC BMSC...
Abstract Objectives: The purpose of this study is to provide a detailed comparison 4 posterior approaches the ankle: posteromedial, modified posteromedial (mPM), Achilles tendon-splitting (TS), and posterolateral approaches. Methods: Cadaveric dissections were performed assess influence medial lateral retraction forces on neuro-vascular bundle with suspension scales measure exposed areas tibia talus. Data was acquired ankle in neutral position plantar flexion. Results: Both mPM TS provided...
Abstract Background We previously reported the development of a scaffold-free Bio three-dimensional (3D) nerve conduit from normal human dermal fibroblasts (NHDFs). The aim this study was to investigate regenerative mechanism peripheral cells using 3D in rat sciatic defect model. Methods conduits composed NHDFs were developed, and cell viability evaluated LIVE/DEAD assay immediately before transplantation 1-week post-surgery. Tracking analysis PKH26-labeled performed assess distribution...
Background Although dorsal subluxation is a typical finding for osteoarthritis of the thumb carpometacarpal (CMC) joint, it difficult to evaluate after trapeziectomy and significance its surgical correction combined with still controversial. The purpose this study was develop method without using landmarks on trapezium. Methods Thirty patients CMC arthritis 13 normal were included in study. Dorsal joint evaluated by measuring distance between volar tip metacarpal base dorsoradial border...
Although decellularized nerve grafts are often used as a bridging material in defect repair, the lack of perfusion support this procedure limits regeneration capacity. To address this, we applied vascularized biogenic conduits, which fibrous membranes prefabricated around silicone rod that contain rich vascularity and macrophages, to repair procedures using grafts. The purpose study is investigate capacity combining conduit graft for peripheral 10-mm model rats.Sixteen adult male rats (F344...
Background: This study represents the clinical results, especially range of motion (ROM) improvement, arthroscopic partial trapeziectomy with suture-button suspensionplasty for symptomatic grade II and III thumb carpometacarpal arthritis a minimum 1-year follow-up. Methods: Thirty-two patients (mean: 67.5 years) treated were retrospectively followed up at least 1 year. The physical assessments included ROM, pain visual analogue scale (VAS), strength, Disabilities Arm, Shoulder, Hand (DASH)...
Surgery using skin flaps is essential for soft tissue reconstruction. However, postoperative ischemic injury of the flap a major complication and top concern after surgery. Currently, evidence-based drugs to fully prevent are not available. The purpose this study was evaluate effect KUS121, VCP modulator, on ischemia rodent model. 26 Sprague-Dawley rats were randomly divided into two groups. experimental group intraperitoneally administered with 100 mg/kg KUS121 dissolved in 5% glucose...
We investigated the functional anatomy of radial sagittal band and possible mechanisms involved in its spontaneous traumatic rupture using seven cadaveric hands. First, extensor tendon excursion change angle between bands path were measured during metacarpophalangeal joint flexion. The then divided two different ways that mimicked or rupture. found no significant correlation middle ring fingers. Dislocation could occur when was only partially divided. This may explain why conservative...
Objective: The perfect O sign is often evaluated in carpal tunnel syndrome but there are no clear criteria. purpose of this study to develop a tool for quantifying the and investigate values healthy subjects using method.
We newly developed a muscle graft that employs doxorubicin pretreatment technique. The aims of this study were to reveal the biological and morphological features tissue in second week (Study I), regeneration outcomes functional kinematic assessments longer-term follow-up (16 weeks, Study II), make with critical-sized nerve defect model (20 mm, III). A total 26 adult rats used study. Doxorubicin treatment was accomplished by immersion solution for 10 minutes followed rinsing procedure....
Background: Arthroscopic partial trapeziectomy with suture-button suspensionplasty was developed for the surgical treatment of thumb carpometacarpal arthritis. However, relationship between clinical results and radiographic evidence is unclear. Methods: The authors retrospectively reviewed 33 consecutive patients who underwent arthroscopic arthritis 2016 2021. Clinical outcomes were recorded, correlations them evaluated. Results: average patient age at surgery 69 years. Patient radiologic...
Abstract Background There is no report of the application intraoperative computed tomography to extremities, and its usefulness not mentioned. Case presentation We present a case patient with elbow pain loss forearm rotation due prominent bicipital tuberosity radius, which was diagnosed as enthesopathy. Surgical treatment excise part radius recommended. However, it difficult perform appropriate excision abnormal because complications such tendon rupture. The successfully treated by surgical...
Abstract There is no report of the application intraoperative computed tomography to extremities, and its usefulness not mentioned. We present a case patient with elbow pain loss forearm rotation due prominent bicipital tuberosity radius, which was diagnosed as enthesopathy. Surgical treatment excise part radius recommended. However, it difficult perform appropriate excision abnormal because complications such tendon rupture. The successfully treated by surgical resection under control...