A5101410932- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Extracellular vesicles in disease
- Lung Cancer Treatments and Mutations
- Urticaria and Related Conditions
- Mesenchymal stem cell research
- Peptidase Inhibition and Analysis
- T-cell and Retrovirus Studies
- Asthma and respiratory diseases
- Musculoskeletal synovial abnormalities and treatments
- Cancer Cells and Metastasis
- Viral Infections and Immunology Research
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Neonatal Respiratory Health Research
- Plant responses to water stress
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Tuberculosis Research and Epidemiology
- Reproductive Biology and Fertility
- Plant Stress Responses and Tolerance
- Mycobacterium research and diagnosis
Kyoto University
1987-2025
Shizuoka University
2025
Osaka University of Pharmaceutical Sciences
2024
Japan Anti Tuberculosis Association
2017-2023
Akira (France)
2022
Osaka Metropolitan University
2022
Himeji Medical Center
2022
National Hospital Organization
2022
Kurashiki Central Hospital
2022
Chiba University
2019-2021
The self-renewal and differentiation properties of cancer stem cells (CSCs) are regulated maintained by the CSC niche. However, mechanism this maintenance, especially maintenance contributed differentiated cells, remains to be fully elucidated. Recently, we have established a model CSCs, miPS-LLCcm, from mouse induced pluripotent (miPSCs). In vitro cultured miPS-LLCcm were autonomously balanced with stem-like including vascular endothelial cells. Under these conditions, appeared stable in...
Several studies have shown that cancer niche can perform an active role in the regulation of tumor cell maintenance and progression through extracellular vesicles-based intercellular communication. However, it has not been reported whether this vesicle-mediated communication affects malignant transformation normal stem cells/progenitors. We previously conditioned medium derived from mouse Lewis Lung Carcinoma (LLC) line convert induced pluripotent cells (miPSCs) into (CSCs), indicating when...
The factors influencing long-term responses to a tumor necrosis factor inhibitor (TNFi) in rheumatoid arthritis (RA) patients currently remain unknown. Therefore, we herein conducted multi-omics analysis of TNFi Japanese RA cohort. Blood samples were collected from 27 biological disease-modifying antirheumatic drug (DMARD)-naive at the initiation and after three months treatment with TNFi. Treatment evaluated one year. Differences gene expression levels peripheral blood mononuclear cells...
ABSTRACT Objectives This longitudinal study investigated the factors associated with hallux valgus (HV) progression in patients rheumatoid arthritis (RA). Methods We included 316 RA who underwent foot radiography 2015 and more than four years later. The HV angle (HVA), first‐second intermetatarsal (IMA), first‐fifth (M1/M5 angle), calcaneal pitch (CP) were measured. Sesamoid position on a non‐weight‐bearing radiograph was divided into seven grades reference to Hardy classification. Factors...
While targeting the interleukin-6 receptor (IL-6R) through use of sarilumab (SAR) or tocilizumab (TCZ) has become a major therapeutic approach for rheumatoid arthritis (RA), direct comparisons between IL-6R inhibitors (IL-6Ris) treating RA have not been conducted. We aimed to compare effectiveness subcutaneous (SAR-SC), (TCZ-SC), and intravenous TCZ (TCZ-IV) against in multicenter cohort study. Within target trial emulation framework, an incident new-user active-comparator design was used....
Abstract Data on the safety of Janus kinase inhibitors (JAKis) in patients with renal impairment are lacking. This study aimed to investigate JAKis compared biological (b) DMARDs rheumatoid arthritis (RA) and impairment. We used a multi-centre observational registry RA Japan (the ANSWER cohort). assessed drug retention rates b/targeted synthetic different modes action (tumour necrosis factor (TNFis), immunoglobulins fused cytotoxic T-lymphocyte antigen (CTLA-4-Ig), interleukin-6 receptor...
Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease of unknown etiology. Under pathological conditions in lungs with IPF, myofibroblasts serve key role fibrogenesis via the accumulation an excessive amount extracellular matrix. To develop effective therapeutic interventions against studies have recently focused on how to dedifferentiate established myofibroblasts. The present study revealed that JQ1, inhibitor bromodomain and extra‑terminal proteins, markedly suppressed expression...
Osteoporosis and osteopenia are significant concerns in rheumatoid arthritis (RA), predisposing patients to fragility fractures. While dual-energy X-ray absorptiometry (DXA) is the gold standard for bone mineral density (BMD) assessment, simpler screening tools needed. This study aims assess correlation between second metacarpal cortical index (2MCI) BMD RA patients, evaluate machine learning (ML) models utilizing 2MCI clinical parameters predicting osteoporosis/osteopenia presence BMD.
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing lung disease that caused by the dysregulation of alveolar epithelial type II cells (AEC II). The mechanisms involved in progression IPF remain incompletely understood, although immune response accompanied p38 mitogen-activated protein kinase (MAPK) activation may contribute to some them. This study aimed examine association activity lungs with bleomycin (BLM)-induced and its transcriptomic profiling. Accordingly, we evaluated...
We report the case of a 61-year-old woman with rapidly progressive interstitial lung disease caused by clinically amyopathic dermatomyositis. Both serum ferritin and anti-melanoma differentiation-associated gene 5 (MDA5) antibody levels were elevated at time admission. Despite intensive treatment corticosteroids, immunosuppressants, immunoglobulins polymyxin B direct hemoperfusion, patient died 75 days after symptom onset. Over course treatment, anti-MDA5 level continually decreased, while...
A human case of creeping eruption due to Gnathostoma nipponicum was confirmed indirectly by finding infective advanced third-stage larvae in leftover largemouth bass meat. This is the first report indicating that (Micropterus salmoides) serves as a source G. infection humans.
Due to the poor capacity for articular cartilage regenerate, its damage tends result in progressively degenerating conditions such as osteoarthritis. To repair damage, transplantation of allogeneic human induced pluripotent stem cell (iPSC)-derived is being considered. However, although effective, immunological reactions can occur. One hypothetical solution delete expression major histocompatibility complex (MHC) class I molecules reduce reactions. For this purpose, we deleted β2...
To identify the risk factors for destruction of large joints in lower extremities patients with rheumatoid arthritis (RA) during a 4-year follow-up period prospective study.We enrolled consecutive who participated both 2012 and 2016. Clinical data, disease activity, types medication were collected 2012. Standard anteroposterior radiographs weight-bearing (hips, knees, ankles) taken Radiographic progression was defined as Larsen grade or need joint arthroplasty arthrodesis. The association...