A5040341729- Rheumatoid Arthritis Research and Therapies
- Orthopedic Infections and Treatments
- Lymphoma Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Bone and Joint Diseases
- Antimicrobial Resistance in Staphylococcus
- Bacterial biofilms and quorum sensing
- Case Reports on Hematomas
- Spinal Fractures and Fixation Techniques
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- HER2/EGFR in Cancer Research
- Spinal Hematomas and Complications
- Musculoskeletal synovial abnormalities and treatments
- Bone health and osteoporosis research
- Atherosclerosis and Cardiovascular Diseases
- Shoulder Injury and Treatment
- Lower Extremity Biomechanics and Pathologies
- Shoulder and Clavicle Injuries
- Tendon Structure and Treatment
- Cancer, Hypoxia, and Metabolism
- Healthcare and Venom Research
- Foot and Ankle Surgery
- Toxin Mechanisms and Immunotoxins
- Galectins and Cancer Biology
Tenri Hospital
2021-2023
NIHR Birmingham Biomedical Research Centre
2023
University Hospitals Birmingham NHS Foundation Trust
2023
National Institute for Health Research
2023
University of Birmingham
2023
Kyoto University
2017-2023
Terumo (Japan)
2023
Kyoto University Hospital
2018
Orthopedic One
2018
The formation of a biofilm on the implant surface is major cause intractable implant-associated infection. To investigate antibiotic concentration needed to eradicate bacteria inside biofilm, minimum eradication (MBEC) has been used, mostly against in vitro biofilms plastic surfaces. produce more clinically relevant environment, an MBEC assay stainless-steel implants formed rat femoral infection model was developed. rats were implanted with stainless steel screws contaminated by two...
Rheumatoid arthritis (RA) is known to cause secondary osteoporosis and fragility fractures. This study aimed identify biomarkers predictive of bone mineral density (BMD) change at three anatomical sites in patients with RA.We conducted a prospective longitudinal RA. In 2012, we recruited 379 from an RA cohort, 329 whom underwent evaluation blood urine together measurement BMD the lumbar spine, proximal femur, distal forearm. The these regions was reassessed 2014. We performed multivariate...
Despite its presence in orthopaedic infections, Staphylococcus epidermidis's ability to directly induce inflammation and bone destruction is unknown. Thus, we compared a clinical strain of methicillin-resistant biofilm-producing S. epidermidis (RP62A) highly virulent osteolytic aureus (USA300) an established murine implant-associated osteomyelitis model. Bacterial burden was assessed by colony forming units (CFUs), tissue damage histology micro-computed tomography, biofilm scanning electron...
Abstract Treatment of implant‐associated orthopedic infections remains challenging, partly because antimicrobial treatment is ineffective after a mature biofilm covers the implant surface. Currently, relative efficacy systemic mono‐ and combination standard‐of‐care (SOC) antibiotic therapies over course formation unknown. Thus, we assessed effects cefazoline (CEZ), gentamicin (GM), vancomycin, with or without rifampin (RFP), on Staphylococcus aureus during establishment osteomyelitis in...
Nonsurgical treatment such as exercise is the preferred method for management of knee osteoarthritis (OA). A combination aerobic, muscle strengthening, and flexibility exercises recommended older adults. However, effects intervention on cartilage metabolism remain unclear. This study used biomarkers to investigate well-rounded program in 42 women (mean age: 59 years). Participants started a weekly supervised continued 12 weeks. Before after program, we measured physical performance Timed...
Objective Tumour necrosis factor alpha (TNF-α) plays an important role in rheumatoid arthritis (RA). TNF-α is synthesised as a membrane-anchored precursor and fully activated by disintegrin metalloproteinase 17 (ADAM17)-mediated ectodomain shedding. Nardilysin (NRDC) facilitates shedding via activation of ADAM17. This study was undertaken to elucidate the NRDC RA. Methods NRDC-deficient ( Nrdc –/– ) mice macrophage-specific delM were examined murine RA models, collagen antibody-induced...
ABSTRACT The aims of this study were to investigate the influence subchondral bone fragility (SBF) on progression knee osteoarthritis by using a novel rat model, and examine preventive effect parathyroid hormone (PTH) cartilage degeneration. First, 40 rats assigned following four groups: Sham, SBF, Medial meniscal tear (MMT), MMT + SBF groups. In groups, we induced microdrilling bone. Second, 10 additional randomly two saline PTH Osteoarthritic changes in articular evaluated safranin‐O/fast...
To identify the risk factors for destruction of large joints in lower extremities patients with rheumatoid arthritis (RA) during a 4-year follow-up period prospective study.We enrolled consecutive who participated both 2012 and 2016. Clinical data, disease activity, types medication were collected 2012. Standard anteroposterior radiographs weight-bearing (hips, knees, ankles) taken Radiographic progression was defined as Larsen grade or need joint arthroplasty arthrodesis. The association...
Objective: Ultrasonography (US) is a useful tool for evaluating the activity of rheumatoid arthritis (RA) patients. As systemic evaluation many joints time-consuming, method to evaluate this with smaller number needed. The aim study was clarify whether assessed may be reduced using patient-oriented joint selection.Methods: A total 492 RA patients were recruited at Kyoto University Hospital. Bilateral metacarpophalangeal (MCP), (proximal) interphalangeal (PIP/IP), and wrist evaluated by US....
The aim of this longitudinal study was to examine the clinical significance soluble lectin-like oxidized low-density lipoprotein receptor 1 (sLOX-1) in patients with rheumatoid arthritis.We gathered demographic and data for a large arthritis cohort at 3 time points. Blood samples were collected each point; number 282 cases 2012, 431 2013, 500 2014. Plasma sLOX-1 measured by enzyme-linked immunosorbent assay. Correlations between analyzed. Predictive factors associated changes factor (RF)...
<h3>Background</h3> Joint damage progression occurs within the first 2 years of rheumatoid arthritis (RA).<sup>1</sup> Large joints are often involved in RA patients. The knee joint, particular, is affected about 30% patients.<sup>2</sup> Knee joint disability thought to be one most important prognostic factors decreasing quality life. However, few studies have focused on what would influence function Therefore, a cross-sectional study this subject was conducted using patient cohort: Kyoto...
<h3>Background</h3> Osteoporosis and its related fractures is one of the most dominant, troublesome complications in rheumatoid arthritis (RA). Newly-introduced drugs such as methotrexate biological targeted synthetic disease modifying anti-rheumatic have decreased activity drastically, but improvement osteoporosis remains to be investigated. <h3>Objectives</h3> To find useful factors for bone mineral density (BMD) management RA patients under current treatment. <h3>Methods</h3> We...
The elbow joints of patients with rheumatoid arthritis (RA) are often destroyed, and total arthroplasty (TEA) is one treatment for these patients. However, RA tend to develop surgical site infections due immunosuppression. Once an implant infected, reoperation may be difficult because the risk reinfection. In such patients, infected must debrided thoroughly, although this might reduce bone scaffold needed re-TEA. We used a unique method manage large ulnar defect implant. patient had...
<h3>Background</h3> Because elbows are important joints for the function of upper limbs, daily activity patients with rheumatoid arthritis (RA) may be impaired by synovitis elbows. Although included into 28 essential evaluation disease RA, ultrasonography (US) examination is not routinely performed and there have been a few surveys on correlation between US scores activity. <h3>Objectives</h3> To reveal whether in RA. <h3>Methods</h3> We recruited 198 RA form KURAMA cohort, which database...