A5112914339- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Childhood Cancer Survivors' Quality of Life
- Neuroblastoma Research and Treatments
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Mesenchymal stem cell research
- Pneumocystis jirovecii pneumonia detection and treatment
- T-cell and B-cell Immunology
- Surgical site infection prevention
- Eosinophilic Disorders and Syndromes
- Hemophilia Treatment and Research
- Prenatal Screening and Diagnostics
- Sarcoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Biochemical and Molecular Research
- PARP inhibition in cancer therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Respiratory viral infections research
- Neurological Complications and Syndromes
Chiba University Hospital
2015-2025
Chiba University
2014-2024
Saitama Children's Medical Center
2017
Fusion genes involving ZNF384 have recently been identified in B-cell precursor acute lymphoblastic leukemia, and 7 fusion partners reported. We further characterized this type of gene by whole transcriptome sequencing and/or polymerase chain reaction. In addition to previously reported genes, we BMP2K as a novel partner for ZNF384. Including the EP300-ZNF384 that recently, total frequency ZNF384-related was 4.1% 291 leukemia patients enrolled single clinical trial, TCF3-ZNF384 most...
Programmed death 1 (PD-1)/programmed ligand (PD-L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD-L1 expression and tumor-infiltrating CD8+ T cells formalin-fixed, paraffin-embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal rhabdomyosarcoma, atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma the...
Purpose: Prophylaxis with recombinant factor VIII (rFVIII) products is the gold-standard treatment for hemophilia A. However, interindividual differences affect half-life and clearance of rFVIII products. The myPKFiT a web-based medical-device software program population pharmacokinetic (PK) simulation FVIII to guide accurate doses dosing intervals. In this Japanese multicenter observational study, efficacy regimen adjustment using was examined. Patients Methods: Male patients A undergoing...
We analyzed a Japanese registry database to elucidate the incidence, risk factors, and outcomes of adenovirus (AdV) disease after autologous allogeneic hematopoietic cell transplantation (HCT) in contemporary real-world patients. evaluated cumulative incidence AdV disease, as well survival, treatment details, among 25 233 patients who underwent HCT 48 380 between 2005 2019. The 1-year incidences were 0.18% 1.52%, respectively, children, 0.49% 2.99%, adults. Among with renourinary infection...
Invariant natural killer T (iNKT) cells are innate-like CD1d-restricted that express the invariant cell receptor (TCR) composed of Vα24 and Vβ11 in humans. iNKT specifically recognize glycolipid antigens such as α-galactosylceramide (αGalCer) presented by CD1d. show direct cytotoxicity toward CD1d-positive tumor cells, especially when CD1d presents antigens. However, recognition CD1d-negative is unknown, remains controversial. Here, we demonstrate activated leukemia a CD1d-independent...
Constitutional 11q interstitial deletion syndrome presents with congenital anomalies including microcephaly craniostenosis, minor dysmorphic features, vitreoretinopathy, and renal anomalies. This is occasionally associated neuroblastoma (NB) as a life‐threatening complication, which important for clinical care. Although the corresponding locus to NB has been predicted exist in 11q22–23 by previous studies related NB, causative haploinsufficient genes have not yet identified. We herein...
Abstract The effect of genetic variation on second malignant neoplasms (SMNs) remains unclear. First, we identified the pathogenic germline variants in cancer-predisposing genes among 15 children with SMNs after childhood leukemia/lymphoma using whole-exome sequencing. Because prevalence was low, focused association between and NUDT15 primary acute lymphoblastic leukemia (ALL) cases. is one 6-mercaptopurine (6-MP) metabolic genes, its are common East Asian individuals. hypomorphic higher...
Immediate allergy to l-asparaginase (ASP) is a major obstacle in treating lymphoid malignancies. ASP-specific immunoglobulin G (ASP-IgG) has been used as surrogate marker. Recently, the CD203c-basophil activation test (BAT) was found be useful diagnosing IgE-mediated allergies. We compared diagnostic utility of CD203c-BAT that ASP-IgG levels determining ASP allergies children. Eight allergic reactions occurred over 75 treatment courses. The sensitivity, specificity and area under receiver...
Background:KMT2A (MLL) rearrangements are among the most frequently occurring chromosomal aberrations in acute myeloid leukemia (AML). The driver mutations KMT2A-rearranged AML have been identified. Our group showed that KRAS (KRAS-MT) independent adverse prognostic factors (Blood Adv. 2020). However, studies lack mutation data at relapse. Aims: We aimed to investigate clonal evolution pattern and significance of clonality KRAS-MT AML. Methods: Samples from pediatric patients with were...
The outcome of multimodal therapy for localized bladder rhabdomyosarcoma is quite good in terms morbidity, and conservative surgery generally recommended. However, cases originating the neck, tumorectomy or partial cystectomy has adverse effects on function. A 2-year-old girl underwent transurethral resection a tumor (TUR-BT), chemotherapy consisting vincristine, actinomycin-D, cyclophosphamide, radiotherapy. She was remission 3 years when frequent urination became evident. Her capacity...