A5091441500- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Chronic Myeloid Leukemia Treatments
- Cytomegalovirus and herpesvirus research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Nutrition and Health in Aging
- Vector-Borne Animal Diseases
- Chronic Lymphocytic Leukemia Research
- Renal Transplantation Outcomes and Treatments
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Animal Disease Management and Epidemiology
- T-cell and B-cell Immunology
- Childhood Cancer Survivors' Quality of Life
- Hemoglobinopathies and Related Disorders
- CAR-T cell therapy research
- Blood groups and transfusion
- Cancer Genomics and Diagnostics
- Viral-associated cancers and disorders
- CNS Lymphoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
Aichi Medical University
2023-2025
The Japanese Data Center for Hematopoietic Cell Transplantation
2023-2025
Nagoya University
2023-2025
Nagoya University Hospital
2025
Japanese Red Cross Nagoya Daiichi Hospital
2019-2021
Granulocyte colony-stimulating factor (G-CSF) accelerates neutrophil recovery after allogeneic hematopoietic cell transplantation (HCT). However, the optimal use of G-CSF and timing its initiation HCT for myelodysplastic syndrome (MDS) according to graft type have not been determined. This retrospective study aimed investigate effects using administration on transplant outcomes in adult patients with MDS undergoing HCT. Using Japanese registry data, we retrospectively investigated among...
Abstract The impact of center volume on outcomes in pediatric hematopoietic cell transplantation (HCT) is not well established. We retrospectively analyzed data from a nationwide registry, including 6966 patients who underwent their first allogeneic HCT at 123 centers Japan between 2001 and 2020. Centers were categorized by transplant as low (C1, the smallest number transplantation), medium-low (C2), medium-high (C3), high (C4, greatest compared across these categories. analysis revealed no...
This study aimed to address the prognostic impact of center experience based on data 7821 adults with acute myeloid leukemia who underwent allogeneic hematopoietic cell transplantation (HCT) from 2010 2019 in Japan, where medical care was provided within a uniform healthcare system. Center defined number HCTs performed for any indication during period, by which centers were divided into low-, intermediate-, and high-volume centers. After adjusting known confounding factors, risk overall...
We retrospectively evaluated the impacts of using granulocyte colony-stimulating factor (G-CSF) and its timing on posttransplant outcomes for 9766 adults with acute myeloid leukemia (AML) between 2013 2022 a Japanese database. separately three distinct cohorts based graft type: 3248 received bone marrow transplantation (BMT), 3066 peripheral blood stem cell (PBSCT), 3452 single-unit cord (CBT). Multivariate analysis showed that G-CSF administration significantly accelerated neutrophil...
Noninfectious transplantation-related complications (TRCs) such as graft-versus-host disease (GVHD) and endothelial cell damage (TRC-EC) are critical after allogeneic hematopoietic stem transplantation. Tacrolimus (TAC) is used to control GVHD. Hypertension renal failure common adverse events TAC treatment. Higher blood concentrations of would be expected reduce the risk GVHD but may increase TRC-EC. TRC-EC often develops in patients with GVHD; thus, it difficult clinically determine proper...
Abstract Background De novo chronic myeloid leukemia in blastic phase (CML‐BP) showing lymphoid immunophenotype mimics Philadelphia chromosome–positive acute lymphoblastic (Ph‐positive ALL). Although upfront allogeneic hematopoietic cell transplantation (HCT) is considered both diseases, it not yet clear whether the transplant outcomes are also similar. Methods Using a registry database, between de CML‐BP and Ph‐positive ALL negative‐minimal residual disease (MRD), positive MRD, nonremission...
Abstract Background and Objectives ABO blood group mismatch between the donor recipient can affect success of transplant as well problems with red cells during allogeneic haematopoietic cell transplantation (HCT). However, impact Rhesus (Rh) D on outcomes in HCT has been poorly elucidated. Materials Methods We retrospectively evaluated RhD post‐transplant 64,923 patients who underwent 2000 2021 using a Japanese registry database. Results Out whole group, 64,293, 322, 270 38 HCTs were done...
<title>Abstract</title> High-dose chemotherapy with autologous stem cell transplantation (ASCT) is an option for patients aged ≥ 65 years relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Few data are available to select suitable chimeric antigen receptor T-cell (CAR-T) therapy bispecific antibodies. We retrospectively analyzed the risk factors poor outcomes 575 Japanese R/R DLBCL who received ASCT at either second complete remission first partial between 2000 and 2010 (n =...
Summary HLA‐haploidentical haematopoietic cell transplantation with post‐transplant cyclophosphamide (PTCy‐haplo) is emerging as an effective alternative due to donor availability and safety. We conducted a nationwide retrospective study comparing the outcomes of PTCy‐haplo both anti‐thymocyte globulin (ATG)‐free ATG‐administered matched unrelated donors (MUD) transplantation, using peripheral blood stem cells first for acute myeloid leukaemia (AML). Our showed lower slower recovery higher...
<title>Abstract</title> Peripheral blood stem cells (PBSC) or bone marrow (BM) is selected as the graft source in setting of allogeneic hematopoietic cell transplantation from HLA-matched related donors. To clarify prognostic impact sources patients with adult T-cell leukemia/lymphoma (ATL), we performed a retrospective study using propensity score analysis. In entire population, 124 and 274 received BM PBSC, respectively. inverse probability treatment weighting method, achieved comparable...
Introduction and Objectives Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is briefly defined as an AML which have multilineage dysplasia (MLD), a history of myelodysplastic syndrome (MDS) and/or MDS-related cytogenetic abnormalities. Recent study showed that AML-MRC exhibits worse clinical outcome than not otherwise specified (AML-NOS). Though allogenic hematopoietic stem cell transplantation (allo-SCT) believed to improve the AML-MRC, few reports had referred its...
Abstract Background Early tacrolimus (TAC) concentrations correlate with the risk of acute graft‐versus‐host disease (aGVHD); however, whether variability early TAC after allo‐HSCT governs occurrence aGVHD remains unknown. Here, we evaluate correlation between intrapatient (IPV) initial and development aGVHD. Methods We retrospectively assessed 202 patients who underwent received standard GVHD prophylaxis by continuous intravenous (iv) infusion iv methotrexate. IPV was calculated using %...