A5073902937- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chemotherapy-related skin toxicity
- Childhood Cancer Survivors' Quality of Life
- Virus-based gene therapy research
- Muscle and Compartmental Disorders
- CAR-T cell therapy research
- Epigenetics and DNA Methylation
- Neonatal Respiratory Health Research
- T-cell and Retrovirus Studies
- Bacterial Infections and Vaccines
- Kawasaki Disease and Coronary Complications
- Cardiovascular Issues in Pregnancy
- Dialysis and Renal Disease Management
- Cancer-related gene regulation
- Electrolyte and hormonal disorders
- Epilepsy research and treatment
- Blood Pressure and Hypertension Studies
- Coronary Artery Anomalies
- Infectious Encephalopathies and Encephalitis
- Birth, Development, and Health
- Bone and Joint Diseases
- Adrenal Hormones and Disorders
- Orthopedic Infections and Treatments
- Lymphadenopathy Diagnosis and Analysis
Social Insurance Saitama Chuo Hospital
2008-2024
Saitama Medical University
2008-2024
Saitama University
2023
Pediatrics and Genetics
2022
Kindai University
2001
Baylor College of Medicine
1999-2000
St. Jude Children's Research Hospital
1998
University of Tokyo Hospital
1997
Osaka University
1984
Fusion genes involving ZNF384 have recently been identified in B-cell precursor acute lymphoblastic leukemia, and 7 fusion partners reported. We further characterized this type of gene by whole transcriptome sequencing and/or polymerase chain reaction. In addition to previously reported genes, we BMP2K as a novel partner for ZNF384. Including the EP300-ZNF384 that recently, total frequency ZNF384-related was 4.1% 291 leukemia patients enrolled single clinical trial, TCF3-ZNF384 most...
Fusion genes involving MEF2D have recently been identified in precursor B-cell acute lymphoblastic leukemia, mutually exclusive of the common risk stratifying genetic abnormalities, although their true incidence and associated clinical characteristics remain unknown. We 16 cases leukemia 1 lymphoma harboring fusions, including MEF2D-BCL9 (n=10), MEF2D-HNRNPUL1 (n=6), one novel MEF2D-HNRNPH1 fusion. The fusions overall was 2.4% among consecutive patients enrolled onto a single trial. They...
Abstract Genome-wide association studies (GWAS) performed mostly in populations of European and Hispanic ancestry have confirmed an inherited genetic basis for childhood acute lymphoblastic leukemia (ALL), but these associations are less clear other races/ethnicities. DNA samples from ALL patients (aged 0–19 years) previously enrolled onto a Tokyo Children’s Cancer Study Group trial were collected during 2013–2015, underwent single nucleotide polymorphism (SNP) microarray genotyping...
Acute encephalopathy has the possibility of sequelae. While early treatment is required to prevent development sequelae, differential diagnosis utmost priority. The aim this study was therefore identify parameters that can facilitate and prediction outcome acute encephalopathy.We reviewed medical charts inpatients from 2005 2011 identified 33 patients with febrile status epilepticus. Subjects were classified into an group (n = 20) a convulsion 13), serum aspartate aminotransferase (AST),...
Self-monitoring values of blood pressure may better reflect the average long-term value than sporadic measurements in physician's office and be more useful for control. In present study, we compared results self-monitoring values, especially morning, with pressure, related these to progression chronic renal insufficiency left ventricular hypertrophy (LVH). Thirty-four patients were selected from 316 subjects (average serum creatinine 1.72 ± 0.15 mg/dl, mean age 52.6 3.5 yrs) accordance...
<i>Background:</i> Extremely low birth weight infants (ELBWI) often suffer from severe hypotension in the early neonatal period. However, few previous studies have ever revealed plasma levels of vasoactive substances which regulate cardiovascular system ELBWI. <i>Objective:</i> To study ELBWI with during first 24 h life. <i>Methods:</i> 22 (gestational age 26.4 ± 1.9 weeks; 751 135 g) were involved study. After initial volume therapy, arbitrarily divided...
Germline genetic variants influence development of pediatric B cell acute lymphoblastic leukemia (B-ALL). Genome-wide association studies (GWAS) have identified several B-ALL susceptibility loci. IKZF1 and PAX5, transcription factors involved in development, been reported as genes for development. Therefore, we hypothesized that rare would be candidate loci B-ALL. Thus, sequenced TCF3, a key factor gene involving Saliva DNA from 527 patients with remission who were registered the Tokyo...
Background: Because of advances in lifesaving and medical technology, there are more children alive that depend on technology. They referred to as "technology-dependent children," they have been increasing number Japan since NICUs (neonatal intensive care units) were encouraged discharge long-term hospitalized create capacity for new babies. However, the government did not an effective means estimating technology-dependent nationwide. In order implement policies support them, it was...
Efficient gene transfer into hematopoietic stem cells offers a number of potential therapeutic applications. However, the relatively low titer retroviral supernatants and requirement for cell division to ensure integration have meant that transduction efficiency has been low. We modified flowthrough approach able consistently increase human progenitor cells. transduced CD34 with vectors encoding truncated nerve growth factor receptor (NGFR) or neo. Retroviral supernatant was pulled through...
Incomplete Kawasaki disease (iKD), which does not satisfy the standard KD diagnostic criteria because required number of principal symptoms is met, sometimes causes coronary aneurysms. Here we report case a patient with iKD who presented only one symptom that resulted in development aneurysm, as evidenced by angiography.
Based on the results of our surveys involving several municipal departments education that support enrollment children requiring medical care in general schools, this report describes Japanese systems to inclusive for these children, current status such support, and related challenges. The systematically began promote their communities before initiation nationwide children. In addition, sections charge also manage affairs human rights education, rather than special education. Such a...
The aim of this study was to assess whether oxidative and inflammatory mediators in the cord blood newborns with funisitis chorioamnionitis can serve as indicators their status, there is a positive association between higher mediator levels an increased risk admission neonatal intensive care unit (NICU). This conducted prospectively neonatology department university hospital. In total, 52 full-term were evaluated, including 17 cases, 13 22 control without or chorioamnionitis. Cord samples...
SUMMARY We report a case of subacute thyroiditis complicated by thyrotoxic myopathy. Previously myopathy has been described as being associated with GRAVES' disease. The patient in this study was 35‐year‐old man who developed proximal dominant muscular weakness and atrophy during the course thyroiditis. His myopathic symptoms regressed his serum thyroxine triiodothyronine levels returned to normal, however it took relatively long period time for them do so. This suggests that marked may...
Compartment syndrome caused by glucose acetate Ringer’s solution in children has not been sufficiently reported. We report the cases of two who developed compartment dorsum hand and forearm after receiving only during hospitalization, with one case requiring a releasing incision. In recent years, frequently used for maintenance infusion. However, it is always safe should be caution due to risk serious side effects infiltration.
Abstract Background Early treatment may improve the prognosis of acute encephalopathy (AE). However, methods for early diagnosis have not yet been established. In this paper, we examined AE. Methods We extracted data on patients with febrile status epilepticus from electronic medical records in our department between March 2016 and April 2021. Among these, 79 who underwent continuous electroencephalography (cEEG) were included study. Patients exhibited psychomotor retardation or abnormal...