A5071561192- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Low-power high-performance VLSI design
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- T-cell and B-cell Immunology
- VLSI and FPGA Design Techniques
- Hematopoietic Stem Cell Transplantation
- Photonic and Optical Devices
- Monoclonal and Polyclonal Antibodies Research
- Semiconductor Lasers and Optical Devices
- Viral Infections and Immunology Research
- Glycosylation and Glycoproteins Research
- Viral gastroenteritis research and epidemiology
- Lymphoma Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Radiation Dose and Imaging
- 3D IC and TSV technologies
- Synthetic Organic Chemistry Methods
- Wine Industry and Tourism
- Erosion and Abrasive Machining
Chiba University
2006-2025
RIKEN Center for Integrative Medical Sciences
2023-2025
Kobe University
2024
Megmilk Snow Brand (Japan)
2024
Morinaga (Japan)
2024
Obihiro University of Agriculture and Veterinary Medicine
2010-2021
Saitama Children's Medical Center
2014-2020
National Center for Global Health and Medicine
2013-2019
Teikyo University Chiba Medical Center
2016-2017
Palmetto Hematology Oncology
2017
Programmed death 1 (PD-1)/programmed ligand (PD-L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD-L1 expression and tumor-infiltrating CD8+ T cells formalin-fixed, paraffin-embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal rhabdomyosarcoma, atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma the...
ABSTRACT While antibody‐dependent cellular cytotoxicity (ADCC) by anti‐disialoganglioside GD2 monoclonal antibody (mAb) has succeeded in increasing the survival rate of high‐risk patients with neuroblastoma, approximately 40%–50% die from disease. Recently, we developed induced pluripotent stem cell‐derived natural killer T (iPS‐NKT) cells, which exhibit NK‐like cytotoxicity. However, whether iPS‐NKT cells can induce ADCC function is unclear. Here, investigated and efficacy combination...
We present a low-power design method that utilizes the multiple supply voltages. The proposed reduces power consumption of random logic circuits by 47% on average, with up to 15% area overhead, combination Clustered Voltage Scaling (CVS) scheme and Row optimized Power Supply (RRPS) scheme. By CVS scheme, optimal netlist, uses minimized number level converters maximized low Vdd gates under timing constraints, is generated. To avoid wiring resource increase interconnect delay caused layout...
Mouse cells expressing the human poliovirus receptor (PVR-mouse cells) as well HeLa are susceptible to type 1 Mahoney strains and produce a large amount of progeny virus at 37 degrees C. However, yield is markedly reduced 40 C in PVR-mouse but not cells. The reduction appears be due defective initiation process positive-strand RNA synthesis (K. Shiroki, H. Kato, S. Koike, T. Odaka, A. Nomoto, J. Virol. 67:3989-3996, 1993). To gain insight into molecular mechanisms involved this detective...
This paper describes an automated design technique to reduce power by making use of two supply voltages. The consists structure synthesis, placement and routing. synthesizer clusters the gates off critical paths so as reduced voltage save power. routing tool assigns either or unreduced one each row minimize area overhead. Combining these techniques together, we applied it random logic modules a media processor chip. combined 47% on average with overhead 15% at logic, while keeping performance,.
Most poliovirus strains infect only primates. The host range (HR) of is thought to be primarily determined by a cell surface molecule that functions as receptor (PVR), since it has been shown transgenic mice are made sensitive introducing the human PVR gene into genome. relative levels neurovirulence polioviruses tested in these were correlate well with monkeys (H. Horie et al., J. Virol. 68:681-688, 1994). Mutants virulent Mahoney strain have generated disruption nucleotides 128 134, at...
Abstract Glioblastoma is the most common and aggressive type of brain tumor with high recurrence fatality rates. Although various therapeutic strategies have been explored, there currently no effective treatment for glioblastoma. Recently, number immunotherapeutic has tested malignant tumors. Invariant natural killer T (iNKT) cells play an important role in anti-tumor immunity. To address if iNKT can target glioblastoma to exert activity, we assessed expression CD1d, antigen-presenting...
Abstract The purpose of this study is to establish a treatment with appropriate intensity for children (<16 years old at diagnosis) de novo acute myeloid leukemia (excluding promyelocytic and associated Down syndrome) according risk stratification based on recurrent leukemic cytogenetic abnormalities flow-cytometric minimal residual disease end initial induction chemotherapy validate the safety efficacy gemtuzumab ozogamicin (GO)-combined post-induction non-low-risk (non-LR) patients....
Hematopoietic stem cell transplantation (HSCT) recipients have a high risk of varicella-zoster virus (VZV) infections. Although VZV vaccination may be beneficial in preventing infections, data on safety and efficacy vaccines HSCT recipients, particularly zoster vaccine, are limited. We report our experience with the use single dose an Oka strain high-titer zoster-equivalent varicella vaccine pediatric allogeneic recipients. administered to 31 without vaccine-type One patient developed due...
Background: Host effector mechanism against Mycobacterium tuberculosis (Mtb) infection is dependent on innate immune response by macrophages and neutrophils the alterations in balanced adaptive immunity.Coordinated release of cytolytic molecules from NK cells T subsequent granule-associated killing infected have been documented; however, their role clinical (TB) still controversy.Objective: To investigate whether circulating granulysin other are associated with number cells, iNKT Vγ9 + Vδ2...
CD25 is an aberrant marker expressed on the leukemic stem cell (LSC) surface and immunotherapy target in acute myeloid leukemia (AML). However, clinical prevalence significance of expression pediatric AML are unknown. High IL2RA/CD25 showed a cell-like phenotype, elevated was associated with lower overall survival (p < .001) event-free Japanese Pediatric Leukemia/Lymphoma Study Group AML-05 study. This finding reproduced without core-binding factor Children's Oncology study cohort. has...
Invariant natural killer T (iNKT) cells are innate-like CD1d-restricted that express the invariant cell receptor (TCR) composed of Vα24 and Vβ11 in humans. iNKT specifically recognize glycolipid antigens such as α-galactosylceramide (αGalCer) presented by CD1d. show direct cytotoxicity toward CD1d-positive tumor cells, especially when CD1d presents antigens. However, recognition CD1d-negative is unknown, remains controversial. Here, we demonstrate activated leukemia a CD1d-independent...
Invariant natural killer T (iNKT) cells play an essential role in antitumor immunity by exerting cytotoxicity and producing massive amounts of cytokines. iNKT express invariant T-cell receptors (TCR) to recognize their cognate glycolipid antigens such as α-galactosylceramide (α-GalCer) presented on CD1d. We recently reported that CD1d-negative leukemia cell line K562 a TCR-dependent manner. However, it remains controversial how use TCRs exhibit cytotoxic activity toward tumors without CD1d...
Background: We investigated whether thymidine phosphorylase (TP) protein level in renal cell carcinoma (RCC) correlates with clinicopathological characteristics and clinical outcomes.
A catalytic allyl-transfer reaction from tertiary homoallylic alcohols to aldehydes was achieved using dibutyltin oxide as a catalyst in toluene under reflux conditions. Various secondary homoallylic were prepared high yield (up 99%). When β-alkylated homoallylic used, branched products exclusively obtained.
Aristolochic acid (AA) nephropathy, first reported as Chinese herbs is a rapidly progressive tubulointerstitial nephropathy that results in severe anemia, interstitial fibrosis and end-stage renal disease. Tubulointerstitial injury was studied mouse model of AA to determine whether low-dose darbepoetin alpha (DPO) treatment prevents acute tubular necrosis fibrosis.AA administered C3H/He mice intraperitoneally some were also treated with 0.1 microg/kg DPO weekly starting on the day...
We investigated the improvement in dispersion of nanometer-sized diamond particles by change ultrasound exposure time. As results, improved with increasing The average particle size 5 µm decreased to less than 100 nm at times 300 and 1200 s. Also, s had a narrow distribution nanometer range. zeta potential on increased about 30 mV an time longer 900
The familial amyloidotic polyneuropathy is strictly associated with point mutations in the coding region of transthyretin gene. Here, we focused on monomer−monomer and dimer−dimer interaction site tetramer. naturally occurring amyloidogenic Tyr114His (Y114H) Tyr116Ser (Y116S) variants formed more amyloid fibrils than wild-type transthyretin, nonamyloidogenic Tyr116Val (Y116V) variant, other previous studies. secondary, tertiary, quaternary structural stabilities Y114H Y116S were compared...
MYH9 disorder is characterized by large platelets and granulocyte inclusion bodies, can be complicated with young-adult onsets of nephropathy, sensorineural hearing loss, cataracts. Congenital cataracts in patients rare, their etiology has not been elucidated. We report a 3-year-old patient who had p.E1066_A1072del mutation developed congenitally. A review the literature reveals that an exon 24 indel mutation, including p.E1066_A1072del, are susceptible to developing congenital should...