A5101691236- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Graphite, nuclear technology, radiation studies
- Respiratory viral infections research
- Metal Alloys Wear and Properties
- Pediatric health and respiratory diseases
- Monoclonal and Polyclonal Antibodies Research
- Herpesvirus Infections and Treatments
- Hematopoietic Stem Cell Transplantation
- Immunodeficiency and Autoimmune Disorders
- Autoimmune and Inflammatory Disorders Research
- Microstructure and Mechanical Properties of Steels
- Virus-based gene therapy research
- Mesenchymal stem cell research
- Cytomegalovirus and herpesvirus research
- Inflammatory Myopathies and Dermatomyositis
- Streptococcal Infections and Treatments
- Glycosylation and Glycoproteins Research
- Aluminum Alloys Composites Properties
- Infectious Encephalopathies and Encephalitis
- Pediatric Urology and Nephrology Studies
- Pneumocystis jirovecii pneumonia detection and treatment
- Parvovirus B19 Infection Studies
Saitama Children's Medical Center
2014-2022
Kawano Masanori Memorial Public Interest Incorporated Foundation for Promotion of Pediatrics
2022
Dana-Farber Cancer Institute
2013
Harvard University
2011-2013
Yokohama Municipal Minato Red Cross Hospital
2005-2011
Sapporo Medical University
2003-2005
Kitasato University
1996-2004
Red Cross Hospital
2001-2004
Saitama Medical University
1989-1998
National Defense Medical College
1989
Regulatory T cell homeostasis is restored in patients with chronic graft-versus-host disease who receive low-dose interleukin-2 therapy.
Examination of the clinical therapeutic efficacy using bone marrow stromal cells, including mesenchymal stem cells (MSC), has recently been focus much investigation. MSC were reported to ameliorate functional deficits after stroke in rats, with some this improvement possibly resulting from action cytokines secreted by these cells. To enhance such cytokine effects, we transfected telomerized human BDNF gene a fiber-mutant F/RGD adenovirus vector and investigated whether contributed improved...
In this study, we investigated the roles of IFN-gamma and IL-6 in induction IgG subclasses from PBMC stimulated with PWM. The presence first half culture period dramatically suppressed production IgG1, whereas spontaneous IgG2 secretion was sharply enhanced by when latter present throughout period. Endogenous shown to be effective IgG1 because inhibited addition anti-IFN-gamma Ab. Because did not act on depleted surface IgG2-bearing cells enhance IgG2, is unlikely as a switching factor....
Objective. Antibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) have recently been associated with immune-mediated necrotizing myopathy, especially in patients statin exposure. As the data are very limited concerning phenotypes and treatment paediatric patients, we aimed to identify positive for anti-HMGCR antibodies clarify their features therapeutic strategies. Methods. We screened 62 who were clinically and/or pathologically suspected inflammatory myopathy...
Abstract Background Stevens–Johnson syndrome ( SJS ) and toxic epidermal necrolysis TEN are rare, but these conditions associated with high mortality. There have been few reports of in children. The aim this study was to evaluate the clinical features outcomes a group Japanese Methods We retrospectively reviewed pediatric cases , from 2000 2015. Results identified 12 three . Six (all were caused by infection, eight n = 5; 3) drug induced. Respiratory complications most common terms organ...
Hematopoietic stem cell transplantation (HSCT) recipients have a high risk of varicella-zoster virus (VZV) infections. Although VZV vaccination may be beneficial in preventing infections, data on safety and efficacy vaccines HSCT recipients, particularly zoster vaccine, are limited. We report our experience with the use single dose an Oka strain high-titer zoster-equivalent varicella vaccine pediatric allogeneic recipients. administered to 31 without vaccine-type One patient developed due...
The aim of this study was to determine the clinical phenotype and outcome interstitial lung disease (ILD) complicated with juvenile dermatomyositis (JDM) or polymyositis (JPM).This a single-center retrospective study. From 1984 2015, we retrospectively reviewed 29 patients who were diagnosed JDM/JPM, among whom eight cases ILD 21 non-ILD. features laboratory findings included chest computed tomography (CT) images that compared between non-ILD.Eight (27.6%) ILD. mean age 6.3 years, 75% women....
It has been suggested that gene-environmental interactions play crucial roles in the development of allergy, especially early life. Analysis twin cases may provide novel insights into pathogenesis and pathophysiology allergy. Though several studies have indicated importance a genetic contribution to expression allergic diseases based on analyses, very few data are available regarding twins with Food Protein-Induced Gastrointestinal Syndrome (FPIGS). Two pairs identical fraternal FPIGS...
To the Editor—Yeoh et al. [1] had reported effectiveness of public health measures introduced during coronavirus disease 2019 (COVID-19) pandemic on respiratory syncytial virus (RSV) infections in Western Australian children. Later, they obvious resurgence RSV cases from last September, and that epidemic season shifted by about half a year [2]. In Japan, we recently began to face similar situation Australia. Here, present data Japanese pediatric sentinel surveillance system under National...
Acute rheumatic fever (ARF) and post-streptococcal reactive arthritis (PSRA) are immune-mediated consequences of group A streptococcal pharyngitis. ARF has declined in developed nations. No prevalence survey PSRA been conducted. This study evaluated the incidence characteristics Japanese children.From 2010 to 2015, were using clinical data retrospectively collected by chart review from 528 hospitals.From 323 hospitals (61% response rate), 44 cases 21 reported. Patients with and/or mainly...
Congenital cytomegalovirus (cCMV) infection leads to sensorineural hearing loss (SNHL) and neurodevelopmental delays. However, the long-term outcomes of cCMV with severe neurological manifestations in infancy remain unclear. The patient was a one-month-old girl visited owing abnormalities neonatal screening. Central nervous system involvement including intracranial calcification extensive white matter identified. Right SNHL (50 dB) detected by auditory brain response (ABR) testing. cause her...
Interleukin (IL)‐10 is a cytokine that regulates inflammatory responses. We studied the role of IL‐10 in development tolerance to Dermatophagoides farinae asthma patients remission, since improves most children during adolescence. The spontaneous production by cultured peripheral blood mononuclear cells (PBMC) was higher with active than normal subjects. decreased when 1 μ g/ml D. added cultures, but increased again dose‐dependent manner concentrations were added. In remission asthma, lower...
Several in vitro studies have suggested the presence of Th2‐skewed immunity during pregnancy infants with atopic diseases. Our study indicated that allergic showed a higher birth weight and shorter gestational period at than those non‐allergic peers. Moreover, mothers gave to neonates whose weights ages were mothers, respectively. Thus, our data clearly demonstrated promotion intrauterine growth, either children, or mothers. Such an environment favorable for fetal growth may also accelerate...