A5101801390- Viral Infections and Immunology Research
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Axon Guidance and Neuronal Signaling
- Viral gastroenteritis research and epidemiology
- Hydrology and Sediment Transport Processes
- Multicomponent Synthesis of Heterocycles
- Erythrocyte Function and Pathophysiology
- Synthesis and Biological Evaluation
- Hydrology and Watershed Management Studies
- RNA Research and Splicing
- Parkinson's Disease Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Animal Virus Infections Studies
- Estrogen and related hormone effects
- Virus-based gene therapy research
- Amyotrophic Lateral Sclerosis Research
- Plant Virus Research Studies
- PI3K/AKT/mTOR signaling in cancer
- Fish Ecology and Management Studies
- Phagocytosis and Immune Regulation
- Quinazolinone synthesis and applications
- Neurogenetic and Muscular Disorders Research
Biogen (United States)
2004-2017
Vanderbilt University
2013
Millennium Engineering and Integration (United States)
2003
The University of Tokyo
1997-1998
Tokyo University of Science
1997
Poly(GP) proteins are a promising pharmacodynamic marker for developing and testing therapeutics treating C9ORF72 -associated amyotrophic lateral sclerosis.
Tyro3, a member of the Tyro3/Axl/Mer (TAM) family receptor tyrosine kinases, has emerged as potential oncogene in melanoma. Here, we confirm that Tyro3 is specifically overexpressed primary melanoma samples and show expressed at varying levels numerous cell lines. Short hairpin RNA-mediated knockdown led to significant death via apoptotic mechanisms nearly all lines tested, regardless BRAF or NRAS mutation status co-expression Axl and/or Mer. We generated soluble monomeric versions human...
Most poliovirus strains infect only primates. The host range (HR) of is thought to be primarily determined by a cell surface molecule that functions as receptor (PVR), since it has been shown transgenic mice are made sensitive introducing the human PVR gene into genome. relative levels neurovirulence polioviruses tested in these were correlate well with monkeys (H. Horie et al., J. Virol. 68:681-688, 1994). Mutants virulent Mahoney strain have generated disruption nucleotides 128 134, at...
The Nogo66 receptor (NgR1) is a neuronal, leucinerich repeat (LRR) protein that binds three central nervous system (CNS) myelin proteins, Nogo, myelin-associated glycoprotein, and oligodendrocyte mediates their inhibitory effects on neurite growth. Although the LRR domains NgR1 are necessary for binding to exact epitope(s) involved in ligand unclear. Here we report generation detailed characterization of an anti-NgR1 monoclonal antibody, 7E11. 7E11 antibody blocks glycoprotein with...
ABSTRACT Instream ecological flow (IEF) provides a reference value for maintaining the stability of river ecosystems and enriching biodiversity. Existing methods determining IEF often consider only one intra-annual runoff distribution characteristics or inter-annual characteristics. In this study, copula-based determination method is proposed to both annual monthly magnitudes. The marginal functions are first determined using maximum likelihood method. Then copula function used construct...
Abstract A mass spectrometry-based proteomic screen in ER+ breast cancer cells revealed that levels of P-REX1 are decreased upon PTEN loss, and increased PI3K inhibition. integrates signaling inputs from receptor tyrosine kinases (RTKs)/PI3K (via the phospholipid product PIP3) G protein-coupled receptors Gbg subunits) to drive guanine exchange factor (GEF) activity on Rac1. RNAi knockdown PREX1 overexpression exogenous respectively activation insulin-like growth receptor-1 (IGF-1R)/insulin...