A5039157337- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Diabetes and associated disorders
- Sexual Differentiation and Disorders
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic function and diabetes
- Diabetes Management and Research
- Bone health and osteoporosis research
- Congenital heart defects research
- Bone health and treatments
- Metabolism and Genetic Disorders
- Immunodeficiency and Autoimmune Disorders
- Neonatal Health and Biochemistry
- Neuroendocrine Tumor Research Advances
- Bone Metabolism and Diseases
- Medical Imaging and Pathology Studies
- Blood groups and transfusion
- Hypothalamic control of reproductive hormones
- Genetics and Neurodevelopmental Disorders
- Parathyroid Disorders and Treatments
- Adrenal Hormones and Disorders
- Neonatal Respiratory Health Research
- Genetic Syndromes and Imprinting
- Thyroid and Parathyroid Surgery
- Oral and Maxillofacial Pathology
Teikyo University Chiba Medical Center
2014-2024
Society for Endocrinology
2017-2022
Japan Pediatric Society
2018
Keio University
2015
Chiba Kaihin Municipal Hospital
2002-2003
Chiba University
1991-2002
The mortality rate in thyroid storm (TS) has been reported to be higher than 10%.
Purpose behind developing these guidelines: Over one decade ago, the “Guidelines for Treatment of Graves’ Disease with Antithyroid Drug, 2006” (Japan Thyroid Association (JTA)) were published as standard drug therapy protocol disease. The Childhood-Onset Drug in Japan, 2008” to provide guidance on treatment pediatric patients. Based new evidence, a revised version (JTA) was 2011, combined “Handbook Radioiodine Therapy 2007” (JTA). Subsequently, newer findings disease have been reported....
Purpose of developing the guidelines: Mass screening for congenital hypothyroidism started in 1979 Japan, and prognosis intelligence has been improved by early diagnosis treatment. The incidence was about 1/4000 birth population, but it increased due to subclinical hypothyroidism. disease requires continuous treatment, specialized medical facilities should make a differential treat subjects who are positive mass avoid unnecessary Guidelines Screening Congenital Hypothyroidism (1998 version)...
Activating mutations of the extracellular calcium (Ca2+e)-sensing receptor (CaR) gene, mostly in its domain, can cause both familial and sporadic hypoparathyroidism. We report a Japanese family with severe hypoparathyroidism pretreatment serum (Ca) levels 4.9–5.9 mg/dL. The proband presented seizure at 6 days age. Her older brother mother, who had also experienced seizures tetany, respectively, likewise A heterozygous missense mutation substituting cysteine for phenylalanine normally present...
Since the attainment of higher bone mineral density (BMD) is a crucial strategy in preventing age-related loss and consequent fracture, we determined when mass lumbar spine (L2-L4) (g/cm2) femoral neck reaches its peak healthy Japanese subjects examined influence early exposure to estrogen deficiency on BMD. We also volumetric BMD, termed apparent (BMAD), neck. Using dual-energy x-ray absorptiometry (DXA) (Hologic QDR-1000), measured BMD both 31 children aged 2-11 yr, 269 (138 males 131...
Purpose of developing the guidelines: The first guidelines for diagnosis and treatment 21-hydroxylase deficiency (21-OHD) were published as a diagnostic handbook in Japan 1989, with focus on patients severe disease. "Guidelines Treatment Congenital Adrenal Hyperplasia (21-Hydroxylase Deficiency) Found Neonatal Mass Screening (1999 revision)" 1999 revised to include 21-OHD very mild or no clinical symptoms. Accumulation cases experience has subsequently improved Based these findings,...
Purpose of developing the guidelines: Newborn screening (NBS) for congenital hypothyroidism (CH) was started in 1979 Japan, and early diagnosis treatment improved intelligence prognosis CH patients. The incidence once about one 5,000-8,000 births, but has been increased with subclinical CH. disease requires continuous specialized medical facilities should conduct differential patients who are positive by NBS to avoid unnecessary treatment. Guidelines Mass Screening Congenital Hypothyroidism...
Objective: The aim of this study was to compare the efficacy and adverse reactions during initial treatment long-term outcome between children adolescents with Graves' disease (GD) treated propylthiouracil (PTU) those methimazole (MMI).
To determine the HLA-DRB1, DQB1, DPB1, A, C, and B genotypes among Japanese children with autoimmune type 1 diabetes.Four hundred thirty patients who were GADAb and/or IA-2Ab-positive (Type 1A) recruited from 37 medical centers as part of a nationwide multicenter collaborative study. DNA samples 83 siblings Type 1A diabetes 149 parent-child trios also analyzed. A case-control study transmission disequilibrium test (TDT) then performed.The susceptible protective DRB1 DQB1 alleles haplotypes...
Japanese IDDM patients have been demonstrated to unique and different HLA associations from white patients. To elucidate the effect of HLA-associated genetic factors on clinical heterogeneity in people, HLA-DRB1, DQA1, DQB1 genotypes 88 childhood-onset were examined by polymerase chain reaction-sequence-specific oligonucleotide (PCR-SSO) or sequence-specific primers (SSP). Of patients, 26 (29.5%) had DRB1*0405-DQA1*0302-DQB1*0401/X (DR4-DQ4/X), 38 (43.2%) DRB1*0901-DQA1*0302-DQB1*0303/X...
Background The etiology of type 1 diabetes (T1D) is heterogeneous and according to presence or absence pancreatic autoantibodies divided into two subtypes: 1A (autoimmune-mediated) 1B (non-autoimmune-mediated). Although several genes have been linked diabetes, the genetic cause in Japanese individuals far from understood. Objective aim this study was test for monogenic forms auto antibody-negative children with T1D. Methods Thirty four (19 males 15 female) unrelated glutamate decarboxylase...
We examined clinical, endocrinological and molecular biological aspects of an estrogen-secreting adrenal carcinoma in 18-month-old male to clarify the pathogenesis this condition. An boy was referred for evaluation progressive bilateral gynecomastia appearance pubic hair. The patient had elevated plasma estradiol (349pg/ml) testosterone (260ng/dl) levels that completely suppressed FSH LH levels, subsequently diagnosed with tumor on right side. After removal a 300-g adenocarcinoma, regressed...
We aimed to evaluate the incidence and characteristics of adrenal crisis in Japanese children with 21-hydroxylase deficiency (21-OHD).We conducted a retrospective nationwide survey for councilors Society Pediatric Endocrinology (JSPE) regarding under 7 years 21-OHD, admitted hospitals from 2011 through 2016. defined as acute impairment general health due glucocorticoid at least two symptoms, signs, or biochemical abnormalities.The JSPE 83 institutions responded this (response rate, 60.1%)....
Jansen-type metaphyseal chondrodysplasia (JMC) has both delayed ossification in long bones and usually hypercalcemia. We report a Japanese male patient with JMC who presented rachitic signs on radiographs, hypercalcemia (13 mg/dl) low %TRP at age 3 months (mo). Hypercalcemia was treated from mo to 11 yr. Progressive widening, splaying fragmentation of the metaphyses have been recognized radiographs which resulted shortened tubular consequent short stature [107 cm (-6.5 SD)] 13 tended...
The PTH/PTHrP receptor (PTHR1) plays an essential role in skeletal development and mediates many other functions of PTH PTHrP. Human PTHR1 gene transcription is controlled by three promoters, P1–P3. most proximal promoter, P3, active bone osteoblast-like cell lines accounts for the majority renal transcripts adults. We have identified a tetranucleotide repeat (AAAG)n polymorphism P3 promoter. In 214 unrelated Japanese, number (n) ranged from 3–8, with AAAG5 allele being frequent (59%). 55...
Objective: Methimazole (MMI) is used as a first-line antithyroid drug in children and adolescents with Graves’ disease (GD). The aim of this study was to evaluate the correlation between initial dose MMI clinical course GD after treatment.
Abstract Aim To examine the contribution of FUT 2 gene and ABO blood type to development Type 1 diabetes in Japanese children. Methods We analysed variants genotypes a total 531 children diagnosed with 448 control subjects. The possible association onset was statistically examined. Results se2 genotype (c.385A>T) found confer susceptibility 1A recessive effects model [odds ratio for se2/se2, 1.68 (95% CI 1.20–2.35); corrected P value = 0.0075]. Conclusions contributed present cohort
The aim of this study was to clarify the significance previously reported susceptibility variants in development autoimmune Type 1 diabetes non-white children. Tested included rs2290400, which has been linked only one on white people. Haplotypes at 17q12-q21 encompassing rs2290400 are known determine early-onset asthma by affecting expression flanking genes.We genotyped 63 428 Japanese people with childhood-onset and 457 individuals without diabetes. Possible association between age onset...
Abstract Disclosure: Y. Furukawa: None. K. Tanaka: O. Isozaki: A. Suzuki: T. Iburi: Tsuboi: M. Iguchi: N. Kanamoto: Minamitani: S. Wakino: Satoh: Teramukai: E. Kimura: Miyake: Akamizu: Context: The mortality rate in thyroid storm (TS) has been reported to be higher than 10%. Even when patients survive, some have irreversible damages. In order improve the prognosis of with TS, appropriate management as well prompt and accurate diagnosis are needed. We created diagnostic criteria 2012...
We report a baby born from mother with strongly positive thyroid stimulation blocking antibody (TSBAB) and nearly undetectable T4 level. This case is unique model of complete absence hormones during fetal early neonatal life in humans. The infant girl was by cesarean section, because bradycardia, after 41 weeks gestation received mechanical ventilation for 3 days. TSH level more than 120 microU/mL the screening. At age 17 days, results function study showed free T3 concentrations, 550...
Agranulocytosis is an extremely serious, although rare, adverse effect of antithyroid drugs (ATDs), including methimazole (MMI) and propylthiouracil (PTU), in children adolescents. There are few reports about the characteristics ATD-induced agranulocytosis Japanese This report presents cases three girls with a retrospective analysis 18 patients agranulocytosis, whose had been referred to drug manufacturer, Chugai Pharmaceutical Co., Ltd. Our 3 patients, ranging age from 12 14 yr, developed...
Objective: The aim of this study was to evaluate clinical manifestations, laboratory findings, and effects antithyroid drugs in younger children with Graves’ disease (GD).