A5025092717- Birth, Development, and Health
- Sexual Differentiation and Disorders
- Obesity, Physical Activity, Diet
- Asthma and respiratory diseases
- Metabolism and Genetic Disorders
- Growth Hormone and Insulin-like Growth Factors
- Respiratory and Cough-Related Research
- Lipoproteins and Cardiovascular Health
- Prenatal Screening and Diagnostics
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genomic variations and chromosomal abnormalities
- Electrolyte and hormonal disorders
- Hormonal and reproductive studies
- Diet and metabolism studies
- Neonatal Respiratory Health Research
- Renal Diseases and Glomerulopathies
- Neonatal and fetal brain pathology
- Thyroid Disorders and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Epilepsy research and treatment
- Fetal and Pediatric Neurological Disorders
- Congenital Diaphragmatic Hernia Studies
- Pediatric health and respiratory diseases
- Neonatal Health and Biochemistry
- Vitamin D Research Studies
Dokkyo Medical University
2015-2024
Yamaguchi Red Cross Hospital
2018-2023
Saiseikai Utsunomiya hospital
2022
Red Cross Hospital
2019-2020
National Clinical Research
2016
Dokkyo Medical University Saitama Medical Center
2016
National Center of Neurology and Psychiatry
2016
Bridge University
2015
Society for Endocrinology
2015
Dokkyo University
2000-2010
Human chromosome 14q32.2 harbors the germline-derived primary DLK1-MEG3 intergenic differentially methylated region (IG-DMR) and postfertilization-derived secondary MEG3-DMR, together with multiple imprinted genes. Although previous studies in cases microdeletions epimutations affecting both DMRs paternal/maternal uniparental disomy 14-like phenotypes argue for a critical regulatory function of two region, precise role individual DMR remains to be clarified. We studied an infant upd(14)pat...
The age of adiposity rebound (AR) is defined as the time at which BMI starts to rise after infancy and thought be a marker later obesity. To determine whether this related future occurrence metabolic syndrome, we investigated relationship timing AR with consequences 12 years age.A total 271 children (147 boys 124 girls) born in 1995 1996 were enrolled study. Serial measurements conducted ages 4 8 months 1, 1.5, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, years, based on was calculated. Plasma lipids...
Short stature caused by biologically inactive growth hormone (GH) is characterized lack of GH action despite high immunoassayable levels in serum and marked catch-up to exogenous administration. We found a heterozygous single-base substitution (A-->G) exon 4 the GH-1 gene girl with short stature, clinically suspected indicate presence bioinactive resulting glycine for aspartic acid at codon 112. confirmed mutant using isoelectric focusing analysis. The locus mutation D112G was within site 2...
To investigate the risk of hypophosphatemia and hypercalcemia in small for gestational age (SGA) extremely low birth weight infants (ELBWI) receiving parenteral nutrition.A retrospective review 58 ELBWI was conducted. Serum calcium (Ca) phosphate (PO4) concentrations on days 1 8 after were examined associations with body measurements nutritional factors 1st week life.Lower standard deviation (SD) scores correlated SGA day 8. Higher amino acid (AA) administration exhibited lower serum PO4...
Purpose behind developing these guidelines: Over one decade ago, the “Guidelines for Treatment of Graves’ Disease with Antithyroid Drug, 2006” (Japan Thyroid Association (JTA)) were published as standard drug therapy protocol disease. The Childhood-Onset Drug in Japan, 2008” to provide guidance on treatment pediatric patients. Based new evidence, a revised version (JTA) was 2011, combined “Handbook Radioiodine Therapy 2007” (JTA). Subsequently, newer findings disease have been reported....
Intensive treatment for newborns with trisomy 13 is controversial because of their lethal prognosis. We report the better life prognosis patients who received intensive treatment. At our hospital, we provided an management to such including resuscitation and surgical procedures as required. Herein, present results a retrospective study (1989–2010) 16 cases None was diagnosed have before birth; 9 were delivered by C-section oxygen administered all during postpartum resuscitation. Mechanical...
Trisomy 18 syndrome is a common autosomal aneuploidy chromosomal abnormality caused by the presence of extra chromosome that leads to malformations various parts body. In this study, we retrospectively investigated effect medical progression and prognosis 44 cases trisomy 18, admitted our neonatal intensive care unit between 1992 2013. The patients were divided into group A (n=20, 1992‑2002) B (n=24, 2003‑2012). Following delivery, karyotype, gender, gestational weeks, birth place, cesarean...
We examined whether epithelial damage is associated with mobilization of neutrophils or eosinophils in the airway lumen during acute exacerbations paediatric asthma. Aspirated sputum samples were harvested from 65 patients (mean age 3.4 +/- 0.4 years) Patients signs infection excluded. The presence conglomerates cells (i.e. "Creola bodies") aspirated was utilized as a marker damage. Among asthma patients, 60% displayed Creola bodies (CrB+: n = 39) their whereas remaining did not (CrB-: 26)....
Leptin is one of the factors affecting serum lipid profile. We investigated association between lipids and leptin/leptin receptor (LEPR) gene polymorphisms in obese Japanese children.One hundred thirty-six children (99 males 37 females, relative weight over than 20%) from 5 to 17 years age were recruited 10 institutes. Four known leptin [(+19)A G, (-2548)G A, (-188)C (-633)C T] four LEPR [Lys109Arg, Gln223Arg, Pro(G)1019Pro(A), Ser(T)343Ser(C)] determined using polymerase chain...
Octreotide, a long-acting somatostatin analog, has been used for treating hypoglycemia caused by congenital hyperinsulinism (CHI). However, octreotide not evaluated in clinical trials and approved any developed country. We aimed to test the efficacy safety of diazoxide-unresponsive CHI through combination single-arm, open-label trial (SCORCH study) an observational study collect data on course patients treated off-label Japan registry). In SCORCH study, 5 were stabilized (blood glucose > 45...
We investigated the relationship of 25-hydroxyvitamin D (25[OH]D) level with obesity and atherosclerosis in Japanese adolescents. examined 492 children (247 boys 245 girls) aged 12-13 years. The serum 25(OH)D was compared among underweight, healthy weight, overweight children. Spearman correlation coefficient analysis performed to examine relationships between body mass index (BMI), plasma lipids, blood pressure compare latter normal (≥20 ng/mL) low (<20 groups. Further, we a multiple...
In recent reports, some kinds of HMG-CoA reductase inhibitors were able to decrease proteinuria and improve renal function. Here we aimed clarify the effect fluvastatin (an inhibitor) on function in children with mild IgA nephropathy.We conducted a prospective controlled study 30 who had been recently diagnosed normocholesterolemic nephropathy following detection minor lesion or focal mesangial proliferation moderate proteinuria. The patients randomly assigned receive both 20 mg 5 mg/kg...
Bronchial asthma is a common but important chronic disease in children all over the world. To take measures against prevalence of childhood asthma, many researchers have surveyed actual statuses developed countries, most Asia-Pacific developing countries including Mongolia such surveys never been sufficiently conducted until now. We thought that this survey, though performed 2009, will give and meaningful information even now taking to prevent prevailing bronchial or under similar...
Aim: Children with Familial Hypercholesterolemia (FH) are widely prescribed statins, and it has been suggested that the effects of statins differ among ethnicities. We compared efficacy safety pitavastatin in children adolescents FH clinical trials conducted Japan Europe.