A5004981982- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Diabetes Treatment and Management
- RNA modifications and cancer
- Lymphoma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Rare-earth and actinide compounds
- Cancer Mechanisms and Therapy
- CNS Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Cancer-related gene regulation
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- PI3K/AKT/mTOR signaling in cancer
- Physics of Superconductivity and Magnetism
- Iron-based superconductors research
- Viral-associated cancers and disorders
- Histone Deacetylase Inhibitors Research
- Chronic Kidney Disease and Diabetes
- Nanomaterials and Printing Technologies
- Nuclear Physics and Applications
- Chronic Lymphocytic Leukemia Research
Kanagawa Dental University
2022-2024
AstraZeneca (Japan)
2022-2024
The University of Texas MD Anderson Cancer Center
2021-2024
Tokyo Medical and Dental University
1999-2024
Kanagawa Prefectural Hospital Organization
2021-2024
Kanagawa Cancer Center
2021-2024
The University of Texas Health Science Center at Houston
2023
The University of Tokyo
1976-2021
Ome Municipal General Hospital
2013
Osaka University
2009-2012
Abstract Chronic kidney disease (CKD) guidelines recommend early identification and intervention to delay the progression of CKD. The Kidney Disease: Improving Global Outcomes (KDIGO) heatmap is widely used for risk evaluation in CKD management; however, real-world evidence on clinical characteristics based KDIGO remains limited worldwide including Japan. In order understand management its diagnostic rates a Japanese setting basis heatmap, we utilized medical record database that contains...
In order to prevent central nervous system ( CNS ) involvement and improve the prognosis of primary intraocular lymphoma PIOL ), we prospectively evaluated efficacy combined therapy using intravitreal methotrexate MTX systemic high‐dose on treatment‐naïve . Patients with newly diagnosed whose was limited eyes were enrolled. The patients treated weekly until ocular lesions resolved, followed by five cycles (3.5 g/m 2 every other week. Ten enrolled in this study completed treatment. All...
FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously found that activates mTORC1/S6K/4EBP1 pathway cooperatively through STAT5/PIM and PI3K/AKT pathways to promote proliferation survival by enhancing eIF4F complex formation required for cap-dependent translation. Here, we show that, contrast BCR/ABL causing Ph-positive leukemias, distinctively serine/threonine kinases RSK1/2 activation of MEK/ERK PDK1 transduce...
Pair-breaking effects induced by 3-MeV proton irradiations are examined in underdoped, optimally doped, and overdoped Ba${}_{1\ensuremath{-}x}$K${}_{x}$Fe${}_{2}$As${}_{2}$ single crystals terms of suppression the superconducting critical temperature ${T}_{c}$. The small residual resistivity (RR) as-grown shows presence negligible intrinsic scatterings, which makes this material a model system for studying effect artificially introduced scatterings. RR ${T}_{c}$ change linearly with dose. As...
FLT3-ITD is the most frequent tyrosine kinase mutation in acute myeloid leukemia (AML) associated with poor prognosis. We previously reported that activation of STAT5 confers resistance to PI3K/Akt inhibitors on FLT3-ITD-positive AML cell line MV4-11 and 32D cells driven by (32D/ITD) but not FLT3 mutated domain (32D/TKD). Here, we report involvement Pim kinases expressed through acquisition this resistance. The specific pan-Pim inhibitor AZD1208 as well PIM447 combination PI3K GDC-0941 or...
Many patients with type 2 diabetes mellitus (T2DM) suffer from complications that impose substantial burdens on prognosis and medical costs. Accumulating evidence has demonstrated the clinical benefit of sodium–glucose cotransporter inhibitors (SGLT2i) cardiovascular renal complications. However, health economic impact SGLT2i remains unclear. The aim this study was to evaluate cost-effectiveness initiating antidiabetic therapy an using Japanese real-world data. We constructed a natural...
Primary intraocular lymphoma ( PIOL ) is a rare lymphoma. Because of difficulties in obtaining tissue samples, little known about the disease's genetic features. In order to clarify these features, we carried out single nucleotide polymorphism array karyotyping IOL using genomic DNA extracted from vitreous fluid. We analyzed 33 samples s consisting 16 s, 12 with central nervous system CNS lesion at diagnosis IOCNSL ), and five secondary following systemic All were B‐cell type. identified...
The activated JAK2-V617F mutant is very frequently found in myeloproliferative neoplasms (MPNs), and its inhibitor ruxolitinib has been clinical use, albeit with limited efficacies. Here, we examine the signaling mechanisms from responses to JAK2-V617F-positive leukemic cell lines, including PVTL-2, newly established a patient post-MPN secondary acute myeloid leukemia, widely used model line HEL. We have that downregulated mTORC1/S6K/4EBP1 pathway at least partly through inhibition of...
The investigation of the mechanisms behind p53 mutations in acute myeloid leukemia (AML) has been limited by lack suitable mouse models, which historically have resulted lymphoma rather than leukemia. This study introduces two new AML models. One model induces mutant and Mdm2 haploinsufficiency early development, showing role myeloid-biased hematopoiesis predisposition, independent p53. second mimics clonal inducing adult hematopoietic stem cells, demonstrating that timing mutation...
We compared the kidney outcomes between patients with diabetic disease (DKD) aged ≥75 years initiating sodium-glucose cotransporter 2 (SGLT2) inhibitors versus other glucose-lowering drugs, additionally presenting or without proteinuria. Using Japan Chronic Kidney Disease Database, we developed propensity scores, implementing a 1:1 matching protocol. The primary outcome included decline rate in estimated glomerular filtration (eGFR), and secondary incorporated composite of 40% reduction eGFR...
We demonstrate a large enhancement of critical current density (Jc) up to 1.0x10^7 A/cm2 at 5 K under self-field in (Ba,K)Fe2As2 single crystals by irradiating 320 MeV Au ions. With the very promising potential this material mind, we have fabricated superconducting wire through powder-in-tube method combined with hot isostatic pressing technique, whose effectiveness has been proven industrial Bi2223 tapes. The Jc 4.2 reached 37 kA/cm2 and 3.0 90 kOe. Magneto-optical imaging confirmed...
To assess the initial manifestation of comorbidities and their impact on mortality risk in patients with type 2 diabetes mellitus (T2DM) without a history cardiovascular or renal complications (i.e., early stages T2DM) compared T2DM. We performed retrospective cohort study using Japanese hospital claims database. The incidence rates (chronic kidney disease [CKD], heart failure [HF], myocardial infarction [MI], peripheral arterial [PAD], stroke) were between T2DM age-/sex-matched (matched...
JAK2-V617F plays a key role in the pathogenesis of myeloproliferative neoplasm. However, its inhibitor ruxolitinib has shown limited clinical efficacies because ruxolitinib-persistent proliferation JAK2-V617F-positive cells. We here demonstrate that USP9X WP1130 or EOAI3402143 (G9) inhibited and induced apoptosis more efficiently cells dependent on than cytokine-activated JAK2. preferentially downregulated activated autophosphorylated by enhancing K63-linked polyubiquitination inducing...
Abstract Lymphoma usually forms solid tumours in patients, and high expression levels of adhesion molecules are observed these tumours. However, Kaposi's sarcoma‐associated herpesvirus (KSHV)‐related primary effusion lymphoma (PEL) does not form molecule is suppressed the cells. Inoculation a KSHV‐associated PEL cell line into peritoneal cavity severe combined immunodeficiency mice resulted formation lymphomas cavity. Proteomics using two‐dimensional difference gel electrophoresis DNA...
Abstract Aims The trajectories of systolic function after admission for acute heart failure (HF) and their effect on clinical outcomes have not been fully elucidated. We aimed to assess changes in left ventricular ejection fraction (LVEF) between the index 1 year discharge examine prognostic implications. Methods results extracted data from a prospective multicentre registry patients hospitalized HF identified 1636 with LVEF at discharge. categorized them into five groups based changes:...
We demonstrate control of the carrier density single phase anatase TiO2 thin films by nearly two orders magnitude modulating growth kinetics during pulsed laser deposition, under fixed thermodynamic conditions. The resistivity and intensity photoluminescence spectra these samples, both which correlate with number oxygen vacancies, are shown to depend strongly on rate. A quantitative model is used explain changes.