A5030300141- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Kruppel-like factors research
- Fibroblast Growth Factor Research
- Immune cells in cancer
- Liver Diseases and Immunity
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Effects and risks of endocrine disrupting chemicals
- Hippo pathway signaling and YAP/TAZ
- HER2/EGFR in Cancer Research
- Cholesterol and Lipid Metabolism
- Genetic factors in colorectal cancer
- Computational Drug Discovery Methods
- Inflammatory Bowel Disease
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
Hangzhou Medical College
2025
Zhejiang Provincial People's Hospital
2025
XinHua Hospital
2020-2024
Shanghai Jiao Tong University
2020-2024
Chiba University
2019-2023
Tianjin University of Science and Technology
2016
Organophosphate esters (OPEs) are a class of alternative replacements for polybrominated diphenyl ethers. In vitro and in vivo studies suggested that OPEs may disrupt the homeostasis sex steroid hormones. However, human evidence children adolescents is limited. We conducted cross-sectional analysis associations between OPE biomarkers hormones among (6–11 years) (12–19 U.S. National Health Nutrition Examination Survey, 2013–2014. Participants aged 6–19 years who had available data on urinary...
Programmed death-ligand 1 (PD-L1) plays an essential role in tumor cell escape from anti-tumor immunity various types of cancer, including gastric cancer (GC). The present study investigated the intracellular and membrane-bound expression PD-L1 GC lines MKN1, MKN74, KATO III OCUM-1. Furthermore, soluble (sPD-L1) level supernatant cells serum patients with healthy controls was determined by ELISA. Interferon (IFN)-γ treatment resulted increased cytoplasmic a dose-dependent manner, except for...
Abstract Both EZH2 and its homolog EZH1 function as histone H3 Lysine 27 (H3K27) methyltransferases repress the transcription of target genes. Dysregulation H3K27 trimethylation (H3K27me3) plays an important role in development progression cancers such hepatocellular carcinoma (HCC). This study investigated relationship between expression EZH1/2 level H3K27me3 HCC. Additionally, cell growth, tumorigenicity, resistance to sorafenib were also analyzed. lentiviral knockdown pharmacological...
Abstract FGF19/FGFR4 autocrine signaling is one of the main targets for multi-kinase inhibitors (MKIs). However, molecular mechanisms underlying in antitumor effects to MKIs hepatocellular carcinoma (HCC) remain unclear. In this study, impact FGFR4/ERK inhibition on HCC following MKI treatment was analyzed vitro and vivo assays. Serum FGF19 patients treated using MKIs, such as sorafenib (n = 173) lenvatinib 40), measured by enzyme-linked immunosorbent assay. Lenvatinib strongly inhibited...
Abnormal autocrine fibroblast growth factor 19 (FGF19) production has been observed in several types of cancers, including hepatocellular carcinoma (HCC). In this study, we investigated the potential serum FGF19 as a novel tumor marker HCC based on sandwich enzyme-linked immunosorbent assay (ELISA).The levels 304 patients with was measured by ELISA. The existing markers, alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) were determined chemiluminescence enzyme immunoassay. Both...
Atezolizumab plus bevacizumab (ATZ/BV) treatment is a combined immunotherapy consisting of immune checkpoint inhibitor (ICI) and anti-vascular endothelial growth factor monoclonal antibody, which has brought major paradigm shift in the unresectable hepatocellular carcinoma (HCC). Gain-of-function mutation CTNNB1 contributes to resistance ICI monotherapy through framework non-T-cell-inflamed tumor microenvironment. However, whether renders ATZ/BV similar remains be elucidated. In this study,...
Hepatocellular carcinoma (HCC) is typically accompanied by abundant arterial blood flow.Although angiogenic growth factors such as Angiopoietin 2 (Ang2) play a central role in tumor angiogenesis HCC, the of serum Ang2 biomarker HCC remains unclear.In this study, we aimed to investigate potential diagnostic and prognostic using sandwich enzyme-linked immunosorbent assay (ELISA).The median levels controls (n=20), chronic liver disease patients (n=98), (n=275) were 1.58, 2.33, 3.53 ng/mL,...
Previous RNA immunoprecipitation followed by proteomic approaches successfully demonstrated that Embryonic Lethal, Abnormal Vision, Drosophila-Like 1 (ELAVL1) interacts with hepatitis B virus (HBV)-derived RNAs. Although ELAVL family proteins stabilize AU-rich element (ARE)-containing mRNAs, their role in HBV transcription remains unclear. This study conducted loss-of-function assays of ELAVL1 for inducible HBV-replicating HepAD38 cells and HBx-overexpressed HepG2 cells. In addition,...
A functional cure of hepatitis B virus (HBV) infection or HB antigen loss is rarely achieved by nucleos(t)ide analogs which target viral polymerase. HBx protein a regulatory associated with HBV replication. We thought to identify antiviral compounds targeting analyzing binding activity. Recombinant GST-tagged was applied on an FDA-approved drug library chip including 1018 determine affinity surface plasmon resonance imaging (SPRi) using PlexArray HT system. GST alone used for control...
Background/Aim: MHC-class I-related chain A (MICA) functions as a ligand for natural killer group D, an activating receptor on (NK) cells, and its expression correlates with the carcinogenesis progression of hepatocellular carcinoma (HCC). Although membranous MICA (mMICA) activates NK soluble forms (sMICA), shed by cleaving enzymes, such disintegrin metalloprotease (ADAM) 9, suppress cells. Therefore, prevention shedding through inhibition ADAM9 has potential to activate cancer immunity. we...
Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC). HBV DNA can get integrated into the hepatocyte genome to promote carcinogenesis. However, precise mechanism by which promotes HCC has not been elucidated.To analyze features integration in using new reference database and detection method.Published data, consisting 426 Liver tumor samples paired adjacent non-tumor samples, were re-analyzed identify sites. Genome Reference Consortium Human Build 38 (GRCh38)...
In the era of immunotherapy, lenvatinib (LEN) still holds an important position in sequential treatment advanced hepatocellular carcinoma (HCC). However, sustained therapeutic effect LEN is not sufficient, and there a need to address development resistance. Neuropilin-1 (NRP1) known act as co-receptor for epidermal growth factor receptor (EGFR), Met, vascular endothelial 2 (VEGFR2), which have been reported be involved this study, we used cell culture vivo transplantation models evaluate...
Benzothiazole derivative (BD): [N-(3-(benzothiazol-2-yl) phenyl)-1H-pyrazole-3-carboxamide] was tested for excretion of total sterols high-fat diet fed C57BL/6J mice in view lipid metabolism.The results showed that BD as supplementation significantly improved the output cholesterol comparison to HF alone.Relevant mRNA expressions HMG-CoA-R, SREBP-2, LDL-R, CYP7A1 and PPARα were altered liver.These suggest could promote play a beneficial role lipids metabolism mice.
Introduction: Primary sclerosing cholangitis (PSC) and Ulcerative colitis (UC) are gastrointestinal disorders induced by abnormal autoimmune mechanisms. In recent years, both UC PSC have reported gene mutations polymorphisms, including genome-wide association studies, there also reports of genes that common to each other. However, their functional analysis has not been sufficiently performed. Therefore, the applicant thought adding mutation information expression in immune system UC, PSC,...
Abstract Previous RNA immunoprecipitation followed by proteomic approaches successfully demonstrated that Embryonic Lethal, Abnormal Vision, Drosophila-Like 1 (ELAVL1) interacts with hepatitis B virus (HBV)-derived RNAs. Although ELAVL family proteins stabilize AU-rich element (ARE)-containing mRNAs, their role in HBV transcription remains unclear. This study conducted loss-of-function assays of ELAVL1 for inducible HBV-replicating HepAD38 cells and HBx -overexpressed HepG2 cells. In...